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Screening spreading depolarizations during epilepsy surgery

  • Original Article - Functional Neurosurgery - Epilepsy
  • Published:
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Abstract

Background

Spreading depolarization (SD) is a fundamental pathophysiological mechanism of both pannecrotic and selective neuronal lesions following deprivation of energy. SD with brain injury has been reported including in one patient during an intracranial operation. However, the incidence of SDs in operative resections is unknown.

Methods

We performed (a) retrospective analysis of intraoperative AC-recordings of 69 patients and (b) a prospective study using intraoperative near-DC recording. All patients had the diagnosis of pharmaco-resistant epilepsy. Both studies were designed to determine the incidence and characteristics of SDs intraoperatively. In the retrospective analysis, we used intraoperative electrocorticography (iECoG) recordings obtained from AC-recording of 69 patients. In the prospective analysis, we used an Octal Bio Amp and Power Lab ECoG recorder with near-DC range.

Results

In the retrospective study, we included 69 patients with a mean of 1 h 3 min of iECoG recordings. In the prospective study, we recruited 20 patients with near DC recordings. A total of 35 h 41 min of iECoG recordings with mean of 2 h 32 min/patient were analyzed. We did not find SD in either study.

Conclusions

SDs were not detected during intraoperative recordings of epilepsy surgery using AC- or DC-amplifiers.

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Authors and Affiliations

  1. Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany

    Edgar Santos & Arturo Olivares-Rivera

  2. Clinical Neurophysiology Department, National Institute of Neurology and Neurosurgery of Mexico, Av. Insurgentes Sur 3877, Col. La Fama, Tlalpan, 14269, Mexico City, Mexico

    Daniel Oswaldo Dávila-Rodríguez, Katia Márquez-Gonzalez, Roberto Díaz-Peregrino, Mario Alonso-Vanegas & Daniel San-Juan

  3. Epilepsy Service, Comprehensive Epilepsy Center of Long Island, Port Jefferson, NY, USA

    David Anschel

Authors
  1. Edgar Santos
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  2. Daniel Oswaldo Dávila-Rodríguez
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  4. Roberto Díaz-Peregrino
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Corresponding author

Correspondence to Daniel San-Juan.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (name of institute/committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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This article is part of the Topical Collection on Functional Neurosurgery - Epilepsy

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Santos, E., Dávila-Rodríguez, D.O., Márquez-Gonzalez, K. et al. Screening spreading depolarizations during epilepsy surgery. Acta Neurochir 161, 911–916 (2019). https://doi.org/10.1007/s00701-019-03870-z

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  • DOI: https://doi.org/10.1007/s00701-019-03870-z

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