Skip to main content
SpringerLink
Log in

Calcified ectopic TSH-secreting pituitary adenoma mimicking craniopharyngioma: a rare case report and literature review

  • Case Report - Pituitaries
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Abstract

Among pituitary adenomas, which are relatively common brain tumors, elements of ectopic, thyroid-stimulating hormone (TSH) secretion, and intratumoral calcification are unusual. Here, we present an extremely rare case of a calcified ectopic TSH-secreting pituitary adenoma arising from the pars tuberalis mimicking craniopharyngioma based on neuroimaging findings. To our knowledge, this is the first case report of calcified ectopic TSH-secreting pituitary adenoma without symptoms of excessive thyroid hormone secretion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Collie RB, Collie MJ (2005) Extracranial thyroid-stimulating hormone-secreting ectopic pituitary adenoma of the nasopharynx. Otolaryngol Head Neck Surg 133:453–454

    Article  PubMed  Google Scholar 

  2. Cooper DS, Wenig BM (1996) Hyperthyroidism caused by an ectopic TSH-secreting pituitary tumor. Thyroid 6:337–343

    Article  PubMed  CAS  Google Scholar 

  3. Jung S, Kim JH, Kim TS, Lee MC, Seo JJ, Park JW, Kang SS (2000) Supradiaphragmatic ectopic adrenocorticotropic hormone-secreting adenoma. Pathol Int 50:901–904

    Article  PubMed  CAS  Google Scholar 

  4. Kohno M, Sasaki T, Narita Y, Teramoto A, Takakura K (1994) Suprasellar ectopic pituitary adenoma-case report. Neurol Med Chir (Tokyo) 34:538–542

    Article  CAS  Google Scholar 

  5. Mindermann T, Wilson CB (1993) Thyrotropin-producing pituitary adenomas. J Neurosurg 79:521–527

    Article  PubMed  CAS  Google Scholar 

  6. Mitsuya K, Nakasu Y, Nioka H, Nakasu S (2004) Ectopic growth hormone-releasing adenoma in the cavenous sinus-case report. Neurol Med Chir (Tokyo) 44:380–385

    Article  Google Scholar 

  7. Nishiike S, Tatsumi KI, Shikina T, Masumura C, Inohara H (2014) Thyroid-stimulating hormone-secreting ectopic pituitary adenoma of the nasopharynx. Auris Nasus Larynx 41(6):586–588

    Article  PubMed  Google Scholar 

  8. Ogiwara T, Nagm A, Yamamoto Y, Hasegawa T, Nishikawa A, Hongo K (2017) Clinical characteristics of pituitary adenomas with radiological calcification. Acta Neurochir 159(11):2187–2192

    Article  PubMed  Google Scholar 

  9. Pasquini E, Faustini-Fustini M, Sciarretta V, Saggese D, Roncaroli F, Serra D, Frank G (2003) Ectopic TSH-secreting pituitary adenoma of the vomerosphenoidal junction. Eur J Endocrinol 148:253–257

    Article  PubMed  CAS  Google Scholar 

  10. Song M, Wang H, Song L, Tian H, Ge Q, Li J, Zhu Y, Li J, Zhao R, Ji HL (2014) Ectopic TSH-secreting pituitary tumor: a case report and review of prior cases. BMC Cancer 28(14):544

    Article  Google Scholar 

  11. Tamaki N, Shirakuni T, Kokunai T, Matsumoto S, Fujimori T, Maeda S (1991) Ectopic pituitary adenoma in the suprasellar cistern: case report. Surg Neurol 35:389–394

    Article  PubMed  CAS  Google Scholar 

  12. Tong A, Xia W, Qi F, Jin Z, Yang D, Zhang Z, Li F, Xing X, Lian X (2013) Hyperthyroidism caused by an ectopic thyrotropin-secreting tumor of the nasopharynx: a case report and review of the literature. Thyroid 23(9):1172–1177

    Article  PubMed  CAS  Google Scholar 

  13. Wang Q, Lu XJ, Sun J, Wang J, Huang CY, Wu ZF (2016) Ectopic suprasellar thyrotropin-secreting pituitary adenoma: case report and literature review. World Neurosurg 95(617):e13–e18

    Google Scholar 

  14. Wilson CB (1984) A decade of pituitary microsurgery. J Neurosurg 61:814–833

    Article  PubMed  CAS  Google Scholar 

  15. Yang J, Liu S, Yang Z, Shi YB (2017) Ectopic thyrotropin secreting pituitary adenoma concomitant with papillary thyroid carcinoma: case report. Medicine (Baltimore) 96(50):e8912

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Yoshiki Hanaoka, Toshihiro Ogiwara, Alhusain Nagm, Jun-ichi Koyama & Kazuhiro Hongo

  2. Department of Neurosurgery, Suwa Red Cross Hospital, Suwa, Japan

    Yukinari Kakizawa

  3. Department of Neurosurgery, Al-Azhar University Faculty of Medicine-Nasr city, Cairo, Egypt

    Alhusain Nagm

  4. Department of Neurosurgery, Seguchi Neurosurgical Hospital, Iida, Japan

    Tatsuya Seguchi & Tatsuro Aoyama

  5. Department of Neurosurgery, Ina Central Hospital, Ina, Japan

    Atsushi Sato

Authors
  1. Yoshiki Hanaoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshihiro Ogiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yukinari Kakizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alhusain Nagm
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tatsuya Seguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tatsuro Aoyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jun-ichi Koyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Atsushi Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kazuhiro Hongo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toshihiro Ogiwara.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures in studies involving human participants were performed in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

The patient has consented to the submission of this case report for submission to the journal.

Additional information

This article is part of the Topical Collection on Pituitaries

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hanaoka, Y., Ogiwara, T., Kakizawa, Y. et al. Calcified ectopic TSH-secreting pituitary adenoma mimicking craniopharyngioma: a rare case report and literature review. Acta Neurochir 160, 2001–2005 (2018). https://doi.org/10.1007/s00701-018-3638-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00701-018-3638-1

Keywords

Search

Navigation