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CeO2/C nanowire derived from a cerium(III) based organic framework as a peroxidase mimic for colorimetric sensing of hydrogen peroxide and for enzymatic sensing of glucose

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Abstract

A metal organic framework obtained from cerium(III) and trimesic acid was pyrolyzed to obtain a novel nanostructure referred to as CeO2/C nanowires. The experimental parameters temperature, precursor and gas atmosphere were optimized. The nanowires show good dispersion and a large number of oxygen vacancies, and this leads to excellent peroxidase-like activity. The nanowires are stable at pH values between 2 and 10, and in the 4–80 °C temperature range. The peroxidase-mimicking activity was exploited in a sensitive colorimetric method for determination of H2O2 by using 3,3′,5,5′-tetramethylbenzidine as the chromogenic substrate. The absorbance at 652 nm increases linearly in the 0.5 to 100 μM H2O2 concentration range. If glucose oxidase is added to a solution containing glucose, H2O2 will be enzymatically produced. This was exploited to design a new method for determination of glucose. The optical response is linear in the 1–100 μM glucose concentration range, and the detection limit is 0.69 μM (at S/N = 3). The method was successfully applied to the determination of glucose in serum samples.

CeO2/C nanowires prepared by Ce-MOF pyrolysis show peroxidase-like activity and are able to catalyze the oxidation of tetramethylbenzidine (TMB) by H2O2. This was applied to glucose oxidase-based colorimetruc determination of glucose in human sera

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Acknowledgements

The financial support of the research was provided by the Natural Science Foundation of China (51678485) and the Research Funding Project of Yangtze Normal University (No. 011160030).

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Authors and Affiliations

  1. The Key Laboratory of Luminescence and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China

    Wenfei Dong & Yuming Huang

  2. The Key Laboratory of Chongqing Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing, 408100, China

    Wenfei Dong

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  1. Wenfei Dong
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Dong, W., Huang, Y. CeO2/C nanowire derived from a cerium(III) based organic framework as a peroxidase mimic for colorimetric sensing of hydrogen peroxide and for enzymatic sensing of glucose. Microchim Acta 187, 11 (2020). https://doi.org/10.1007/s00604-019-4032-2

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  • DOI: https://doi.org/10.1007/s00604-019-4032-2

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