Skip to main content
SpringerLink
Log in

Superlattice stacking by hybridizing layered double hydroxide nanosheets with layers of reduced graphene oxide for electrochemical simultaneous determination of dopamine, uric acid and ascorbic acid

  • Original Paper
  • Published:
Microchimica Acta Aims and scope Submit manuscript

Abstract

A self-assembled periodic superlattice material was obtained by integrating positively charged semiconductive sheets of a Zn-NiAl layered double hydroxide (LDH) and negatively charged layers of reduced graphene oxide (rGO). The material was used to modify a glassy carbon electrode which then is shown to be a viable sensor for the diagnostic parameters dopamine (DA), uric acid (UA) and ascorbic acid (AA). The modified GCE displays excellent electrocatalytic activity towards these biomolecules. This is assumed to be due to the synergistic effects of (a) excellent interfacial electrical conductivity that is imparted by direct neighboring of conductive rGO to semiconductive channels of LDHs, (b) the superb intercalation feature of LDHs, and (c) the enlarged surface with an enormous number of active sites. The biosensor revealed outstanding electrochemical performances in terms of selectivity, sensitivity, and wide linear ranges. Typically operated at working potentials of −0.10, +0.13 and + 0.27 V vs. saturated calomel electrode, the lower detection limits for AA, DA and UA are 13.5 nM, 0.1 nM, and 0.9 nM, respectively, at a signal-to-noise ratio of 3. The sensor was applied to real-time tracking of dopamine efflux from live human nerve cells.

Schematic of the preparation of a superlattice self-assembled material by integrating positively charged semiconductive sheets of Zn-NiAl layered double hydroxide (LDH) with negatively charged reduced graphene oxide (rGO) layers. It was applied to simultaneous electrochemical detection of dopamine (DA), uric acid and ascorbic acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Yue HY, Huang S, Chang J, Heo C, Yao F, Adhikari S, Gunes F, Liu LC, Lee TH, Oh ES (2014) ZnO nanowire arrays on 3D hierachical graphene foam: biomarker detection of Parkinson’s disease. ACS Nano 8:1639–1646

    Article  CAS  Google Scholar 

  2. Tavakolian E, Tashkhourian J (2018) Sonication-assisted preparation of a nanocomposite consisting of reduced graphene oxide and CdSe quantum dots, and its application to simultaneous voltammetric determination of ascorbic acid, dopamine and uric acid. Microchim Acta 185:145–152

    Article  Google Scholar 

  3. Li Y, Jiang Y, Song Y, Li S (2018) Simultaneous determination of dopamine and uric acid in the presence of ascorbic acid using a gold electrode modified with carboxylated graphene and silver nanocube functionalized polydopamine nanospheres. Microchim Acta 185:382–391

    Article  Google Scholar 

  4. Taleb M, Ivanov R, Bereznev S, Kazemi SH, Hussainova I (2017) Ultra-sensitive voltammetric simultaneous determination of dopamine, uric acid and ascorbic acid based on a graphene-coated alumina electrode. Microchim Acta 184:4603–4610

    Article  CAS  Google Scholar 

  5. Wang L, Dong Y, Zhang Y, Zhang Z, Chi K, Yuan H, Zhao A, Ren J, Xiao F, Wang S (2016) PtAu alloy nanoflowers on 3D porous ionic liquid functionalized graphene-wrapped activated carbon fiber as a flexible microelectrode for near-cell detection of cancer. NPG Asia Mater 8:337–345

    Article  Google Scholar 

  6. Ghazizadeh AJ, Afkhami A, Bagheri H (2018) Voltammetric determination of 4-nitrophenol using a glassy carbon electrode modified with a gold-ZnO-SiO2 nanostructure. Microchim Acta 185:296–303

    Article  Google Scholar 

  7. Asif M, Aziz A, Ashraf G, Wang Z, Wang J, Azeem M, Chen X, Xiao F, Liu H (2018) Facet-inspired core-shell gold nanoislands on metal oxide octadecahedral heterostructures: high sensing performance toward sulfide in biotic fluids. ACS Appl Mater Interfaces 10:36675–36685

    Article  CAS  Google Scholar 

  8. Zhang X, Zhang YC, Ma LX (2016) One-pot facile fabrication of graphene-zinc oxide composite and its enhanced sensitivity for simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid. Sens Actua B: Chemical 227:488–496

    Article  CAS  Google Scholar 

  9. He W, Ding Y, Ji L, Zhang X, Yang F (2017) A high performance sensor based on bimetallic NiCu nanoparticles for the simultaneous determination of five species of biomolecules. Sens Actua B: Chemical 241:949–956

    Article  CAS  Google Scholar 

  10. Xu Z, Yang L, Xu C (2015) Pt@UiO-66 heterostructures for highly selective detection of hydrogen peroxide with an extended linear range. Anal Chem 87:3438–3444

    Article  CAS  Google Scholar 

  11. Asif M, Aziz A, Azeem M, Wang Z, Ashraf G, Xiao F, Chen X, Liu H (2018) A review on electrochemical biosensing platform based on layered double hydroxides for small molecule biomarkers determination. Adv Colloid Interf Sci 262:21–38

    Article  CAS  Google Scholar 

  12. Asif M, Liu H, Aziz A, Wang H, Wang Z, Ajmal M, Xiao F (2017) Core-shell iron oxide-layered double hydroxide: high electrochemical sensing performance of H2O2 biomarker in live cancer cells with plasma therapeutics. Biosens Bioelectron 97:352–359

    Article  CAS  Google Scholar 

  13. Asif M, Haitao W, Shuang D, Aziz A, Zhang G, Xiao F, Liu H (2017) Metal oxide intercalated layered double hydroxide nanosphere: with enhanced electrocatalyic activity towards H2O2 for biological applications. Sens Actua B: Chemical 239:243–252

    Article  CAS  Google Scholar 

  14. Gu F, Cheng X, Wang S, Wang X, Lee PS (2015) Oxidative intercalation for monometallic Ni2+-Ni3+layered double hydroxide and enhanced capacitance in exfoliated nanosheets. Small 11:2044–2050

    Article  CAS  Google Scholar 

  15. Tel-Vered R, Kahn JS, Willner I (2016) Layered metal nanoparticle structures on electrodes for sensing, switchable controlled uptake/release, and photo-electrochemical applications. Small 12:51–75

    Article  CAS  Google Scholar 

  16. Wang Q, O’Hare D (2012) Recent advances in the synthesis and application of layered double hydroxide (LDH) nanosheets. Chem Rev 112:4124–4155

    Article  CAS  Google Scholar 

  17. Zhao MQ, Zhang Q, Huang JQ, Wei F (2012) Hierarchical nanocomposites derived from nanocarbons and layered double hydroxides-properties, synthesis, and applications. Adv Funct Mater 22:675–694

    Article  CAS  Google Scholar 

  18. Zan X, Bai H, Wang C, Zhao F, Duan H (2016) Graphene Paper decorated with a 2D array of dendritic platinum nanoparticles for ultrasensitive electrochemical detection of dopamine secreted by live cells. Chem 22:5204–5210

    Article  CAS  Google Scholar 

  19. Asif M, Aziz A, Dao AQ, Hakeem A, Wang H, Dong S, Zhang G, Xiao F, Liu H (2015) Real-time tracking of hydrogen peroxide secreted by live cells using MnO2 nanoparticles intercalated layered doubled hydroxide nanohybrids. Anal Chim Acta 898:34–41

    Article  CAS  Google Scholar 

  20. Marcano DC, Kosynkin DV, Berlin JM, Sinitskii A, Sun Z, Slesarev A, Alemany LB, Lu W, Tour JM (2010) Improved synthesis of graphene oxide. ACS Nano 4:4806–4814

    Article  CAS  Google Scholar 

  21. Shervedani RK, Karevan M, Amini A (2014) Prickly nickel nanowires grown on Cu substrate as a supersensitive enzyme-free electrochemical glucose sensor. Sens Actuat B: Chemical 204:783–790

    Article  CAS  Google Scholar 

  22. He W, Ding Y, Zhang W, Ji L, Zhang X, Yang F (2016) A highly sensitive sensor for simultaneous determination of ascorbic acid, dopamine and uric acid based on ultra-small Ni nanoparticles. J Electroanal Chem 775:205–211

    Article  CAS  Google Scholar 

  23. Ma L, Wang Q, Islam SM, Liu Y, Ma S, Kanatzidis MG (2016) Highly selective and efficient removal of heavy metals by layered double hydroxide intercalated with the MoS4 (2-) ion. J Am Chem Soc 138:2858–2866

    Article  CAS  Google Scholar 

  24. Hu J, Lei G, Lu Z, Liu K, Sang S, Liu H (2015) Alternating assembly of Ni–Al layered double hydroxide and graphene for high-rate alkaline battery cathode. Chem Commun 51:9983–9986

    Article  CAS  Google Scholar 

  25. Li M, Liu F, Cheng JP, Ying J, Zhang XB (2015) Enhanced performance of nickel–aluminum layered double hydroxide nanosheets/carbon nanotubes composite for supercapacitor and asymmetric capacitor. J Alloys Compd 635:225–232

    Article  CAS  Google Scholar 

  26. Aziz A, Asif M, Azeem M, Ashraf G, Wang Z, Xiao F, Liu H (2018) Self-stacking of exfoliated charged nanosheets of LDHs and graphene as biosensor with real-time tracking of dopamine from live cells. Anal Chim Acta 65:1–11

    Google Scholar 

  27. Ghanbari K, Moloudi M (2016) Flower-like ZnO decorated polyaniline/reduced graphene oxide nanocomposites for simultaneous determination of dopamine and uric acid. Anal Biochem 512:91–102

    Article  CAS  Google Scholar 

  28. Li B, Zhou Y, Wu W, Liu M, Mei S, Zhou Y, Jing T (2015) Highly selective and sensitive determination of dopamine by the novel molecularly imprinted poly (nicotinamide)/CuO nanoparticles modified electrode. Biosens Bioelectron 67:121–128

    Article  CAS  Google Scholar 

  29. Ramachandran A, Panda S, Karunakaran Yesodha S (2018) Physiological level and selective electrochemical sensing of dopamine by a solution processable graphene and its enhanced sensing property in general. Sens Actuat B: Chemical 256:488–497

    Article  CAS  Google Scholar 

  30. Zhao D, Yu G, Tian K, Xu C (2016) A highly sensitive and stable electrochemical sensor for simultaneous detection towards ascorbic acid, dopamine, and uric acid based on the hierarchical nanoporous PtTi alloy. Biosens Bioelectron 82:119–126

    Article  CAS  Google Scholar 

  31. Zhang D, Li L, Ma W, Chen X, Zhang Y (2017) Electrodeposited reduced graphene oxide incorporating polymerization of l-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid. Mater Sci Eng C Mater Biol Appl 70:241–249

    Article  CAS  Google Scholar 

  32. Thanh TD, Balamurugan J, Lee SH, Kim NH, Lee JH (2016) Effective seed-assisted synthesis of gold nanoparticles anchored nitrogen-doped graphene for electrochemical detection of glucose and dopamine. Biosens Bioelectron 81:259–267

    Article  CAS  Google Scholar 

  33. Yan X, Gu Y, Li C, Tang L, Zheng B, Li Y, Zhang Z, Yang M (2016) Synergetic catalysis based on the proline tailed metalloporphyrin with graphene sheet as efficient mimetic enzyme for ultrasensitive electrochemical detection of dopamine. Biosens Bioelectron 77:1032–1038

    Article  CAS  Google Scholar 

  34. Zhang M, Liao C, Yao Y, Liu Z, Gong F, Yan F (2014) High-performance dopamine sensors based on whole-graphene solution-gated transistors. Adv Funct Mater 24:978–985

    Article  CAS  Google Scholar 

  35. Sudibya HG, Ma J, Dong X, Ng S, Li LJ, Liu XW, Chen P (2009) Interfacing glycosylated carbon nanotube network devices with living cells to detect dynamic secretion of biomolecules. Angew Chem Int Ed 48:2723–2726

    Article  CAS  Google Scholar 

  36. Li BR, Hsieh YJ, Chen YX, Chung YT, Pan CY, Chen YT (2013) An ultrasensitive nanowire-transistor biosensor for detecting dopamine release from living PC12 cells under hypoxic stimulation. J Am Chem Soc 135:16034–16037

    Article  CAS  Google Scholar 

Download references

Acknowledgements

National Natural Science Foundation of China (No. 51572094, 51435006), the Innovation Foundation of Huazhong University of Science (No. 2015TS150, 2015ZZGH010) and Technology and the Key Laboratory for Large-Format Battery Materials and System. We acknowledge the support of the Analytical and Testing Center of the Huazhong University of Science and Technology for SEM and XPS measurements.

Author information

Author notes

  1. Muhammad Asif and Ayesha Aziz contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

    Muhammad Asif, Ayesha Aziz, Haitao Wang, Zhengyun Wang, Wei Wang, Muhammad Ajmal, Fei Xiao & Hongfang Liu

  2. State Key Laboratory of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

    Muhammad Asif & Xuedong Chen

Authors
  1. Muhammad Asif
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ayesha Aziz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Haitao Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhengyun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Muhammad Ajmal
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Fei Xiao
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Xuedong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hongfang Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Fei Xiao, Xuedong Chen or Hongfang Liu.

Ethics declarations

The author(s) declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(DOC 667 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Asif, M., Aziz, A., Wang, H. et al. Superlattice stacking by hybridizing layered double hydroxide nanosheets with layers of reduced graphene oxide for electrochemical simultaneous determination of dopamine, uric acid and ascorbic acid. Microchim Acta 186, 61 (2019). https://doi.org/10.1007/s00604-018-3158-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00604-018-3158-y

Keywords

Search

Navigation