Abstract
Purpose
Invasive pulmonary aspergillosis (IPA) after liver transplantation (LT) is most often fatal. We analyzed the outcomes of IPA in a single center.
Methods
We reviewed, retrospectively, the medical records of recipients of living donor LT (LDLT) or deceased donor LT (DDLT) performed between 1995 and 2019 at our institute. We analyzed the incidence of IPA and assessed the treatment courses of patients treated successfully and those not treatment successfully.
Results
Among 326 recipients, IPA was diagnosed in 6 (1.8%). The incidence of IPA was significantly higher in patients with acute liver failure (ALF, 9.8%) than in those without ALF (0.4%), after DDLT (8.8%) than after LDLT (1.0%), and in recipients who received preoperative steroid pulse therapy (16.0%) than in those who did not (0.7%). Complete cure of IPA was achieved in the most recent three patients, by administering voriconazole immediately after the diagnosis of IPA and performing lung resection, while the IPA lesion was single and localized.
Conclusions
Patients with risk factors for IPA must be monitored closely. Our three successfully treated cases demonstrate that initiating immediate voriconazole treatment and making a calculated decision about lung resection can contribute to a favorable outcome.
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Acknowledgements
We thank Dr. Katsuhiko Kamei, Professor of Medical Mycology Research Center, Chiba University in Japan, for his help with the identification of some fungal isolates.
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There are some conflicts of interest to declare: Masahiro Shinoda, Eisai Co., Ltd and Taiho pharmaceutical Co., Ltd; Yuko Kitagawa, ONO PHARMACEUTICAL CO., LTD., Bristol-Myers Squibb, Olympus Corporation, AsahiKASEI Co., Ltd., TAIHO PHARMACEUTICAL CO., LTD., CHUGAI PHARMACEUTICAL CO., LTD., Otsuka Pharmaceutical Co., Ltd., TSUMURA & CO., Takeda Pharmaceutical Co., Ltd., MEDICON INC., Yakult Honsha Co., Ltd., EA Pharma Co. Ltd., Eisai Co. Ltd.
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Abe, K., Shinoda, M., Uno, S. et al. Invasive pulmonary aspergillosis after liver transplantation: lessons from successfully treated cases and review of the literature. Surg Today 51, 1361–1370 (2021). https://doi.org/10.1007/s00595-021-02263-z
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DOI: https://doi.org/10.1007/s00595-021-02263-z