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Etiology and impact on outcomes of polycystic kidney disease in abdominal aortic aneurysm

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Abstract

Purpose

We investigated the etiology and impact on outcomes of polycystic kidney disease in patients with abdominal aortic aneurysm.

Methods

Eight-hundred patients who underwent open (n = 603) or endovascular aortic repair (n = 197) were divided into three groups: no cyst (n = 204), non-polycystic kidney (n = 503), and polycystic kidney (≥ 5 cysts in the bilateral kidneys, n = 93). The characteristics and outcomes were compared among the groups.

Results

In the polycystic kidney group, the age was increased and the proportions of patients with male sex, hypertension, and estimated glomerular filtration rate < 30 mL/min/1.73 m2 were greater. The overall hospital mortality rates were similar. The incidence of acute kidney injury after elective open aortic repair was increased in the polycystic kidney group (12%, 17%, and 29%, P = 0.020). In the polycystic kidney group, 80 patients did not have renal enlargement or a family history of renal disease, while 13 (corresponding to 1.6% [13/800] of the overall patients), had renal enlargement, suggesting the possibility of hereditary polycystic kidney disease.

Conclusions

In our cohort, 1.6% of the patients with abdominal aortic aneurysm who underwent surgery were at risk of hereditary polycystic kidney disease. Polycystic kidney disease was associated with acute kidney injury after open aortic repair.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanumacho, Omiya-ward, Saitama, 330-8503, Japan

    Mitsunori Nakano, Naoyuki Kimura, Takao Nonaka, Yuichiro Kitada, Daijiro Hori, Koichi Yuri, Harunobu Matsumoto & Atsushi Yamaguchi

  2. Department of Medical Informatics, Center for Information, Jichi Medical University, Shimotsuke, 329-0498, Japan

    Makiko Mieno

  3. Department of Radiology, Saitama Medical Center, Jichi Medical University, Saitama, 330-0834, Japan

    Keisuke Tanno

  4. Data Science Center, Jichi Medical University, Shimotsuke, 329-0498, Japan

    Yusuke Sasabuchi

  5. Department of General Internal Medicine, School of Medicine, The Jikei University, Tokyo, 105-8461, Japan

    Kazushige Hanaoka

Authors
  1. Mitsunori Nakano
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  2. Naoyuki Kimura
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  3. Takao Nonaka
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Correspondence to Naoyuki Kimura.

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Nakano, M., Kimura, N., Nonaka, T. et al. Etiology and impact on outcomes of polycystic kidney disease in abdominal aortic aneurysm. Surg Today 50, 1213–1222 (2020). https://doi.org/10.1007/s00595-020-01997-6

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  • DOI: https://doi.org/10.1007/s00595-020-01997-6

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