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Cardiorespiratory fitness and right ventricular mechanics in uncomplicated diabetic patients: Is there any relationship?

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Abstract

Aims

This study investigated the association between cardiorespiratory fitness and right ventricular (RV) strain in uncomplicated diabetic patients.

Methods

This cross-sectional study involved 70 controls and 61 uncomplicated patients with type 2 diabetes, who underwent laboratory analysis, comprehensive echocardiographic study and cardiopulmonary exercise testing.

Results

RV endocardial and mid-myocardial longitudinal strains were significantly reduced in diabetic subjects (− 27.5 ± 4.2% vs. − 25.3 ± 4.3%, p = 0.004 for endocardial strain; − 25.6 ± 3.5% vs. − 24.1 ± 3.2%, p = 0.012 for mid-myocardial strain). The same was revealed for endocardial and mid-myocardial of RV free wall. There was no difference in RV epicardial strain. VO2 was significantly lower in the diabetic group (27.8 ± 4.5 ml/kg/min vs. 21.5 ± 4.2 ml/kg/min, p < 0.001), whereas ventilation/carbon dioxide slope was significantly higher in diabetic subjects (25.4 ± 2.9 vs. 28.6 ± 3.3). Heart rate recovery was significantly lower in diabetic patients. HbA1c and global RV endocardial longitudinal strain were independently associated with peak VO2 and oxygen pulse in the whole study population.

Conclusion

Diabetes impacts RV mechanics, but endocardial and mid-myocardial layers are more affected than epicardial layer. RV endocardial strain and HbA1c were independently associated with cardiorespiratory fitness in the whole study population. Our findings show that impairment in RV strain and cardiorespiratory fitness may be useful indicators in early type 2 diabetes, prior to the development of further complications.

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Author information

Author notes

  1. Vladan Vukomanovic and Jelena Suzic-Lazic have contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, University Clinical Hospital Center “Dr. Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, 11000, Belgrade, Serbia

    Vladan Vukomanovic, Jelena Suzic-Lazic, Vera Celic, Dusan Skokic & Marijana Tadic

  2. Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano IRCCS, Viale della Resistenza 23, 20036, Meda, Italy

    Cesare Cuspidi

  3. Cardiac Magnetic Resonance Unit, Department of Radiology and Cardiovascular Imaging, IRCCS San Raffaele Hospital and University, Milan, Italy

    Antonio Esposito

  4. Clinica Medica, Department of Medicine and Surgery, University Milano-Bicocca, Milan, Italy

    Guido Grassi

  5. Department of Internal Medicine and Cardiology, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburgerplatz 1, 13353, Berlin, Germany

    Marijana Tadic

Authors
  1. Vladan Vukomanovic
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  2. Jelena Suzic-Lazic
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  3. Vera Celic
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  4. Cesare Cuspidi
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  5. Dusan Skokic
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  6. Antonio Esposito
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  7. Guido Grassi
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  8. Marijana Tadic
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Corresponding author

Correspondence to Marijana Tadic.

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The authors declare that they have no conflict of interest.

Ethical standard statement

The study was approved by the local ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all the participants.

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Vukomanovic, V., Suzic-Lazic, J., Celic, V. et al. Cardiorespiratory fitness and right ventricular mechanics in uncomplicated diabetic patients: Is there any relationship?. Acta Diabetol 57, 425–431 (2020). https://doi.org/10.1007/s00592-019-01449-9

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  • DOI: https://doi.org/10.1007/s00592-019-01449-9

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