Skip to main content
Log in

Proximal junctional kyphosis in adult spinal deformity: a novel predictive index

  • Original Article
  • Published:
European Spine Journal Aims and scope Submit manuscript

Abstract

Purpose

Proximal junctional kyphosis (PJK) is a devastating complication for adult spinal deformity (ASD) after correction surgery. However, there is no consensus on the risk factors of PJK, and whether it can be predicted remains unknown. The aim of this study is to detect the primary risk factors for PJK in ASD, and introduce a novel index for prediction of PJK.

Methods

Medical records of 62 ASD patients receiving correction surgery from January 2010 to January 2015 were analyzed. Spino-pelvic parameters were evaluated on lateral films before surgery, at 2 weeks’ and at follow-up. Primary factors for PJK were evaluated. PJK index was proposed and verified.

Results

Cervical lordosis at follow-up, postoperative C2-C7 SVA, C2-C7 SVA at follow-up, postoperative T1 slope, T1 slope at follow-up, preoperative TLK, LL at follow-up, preoperative PT, postoperative PT, PT at follow-up, preoperative SS, postoperative SS, SS at follow-up, preoperative PT/SS, postoperative PT/SS and PT/SS at follow-up were significantly different between ASD with and without PJK. Adjusted logistic regression analysis showed that preoperative TLK, LL at follow-up, preoperative PT/SS and PT/SS at follow-up were primary factors for PJK. PJK index was defined as 0.160*LL at follow-up-0.121*preoperative TLK-4.625*preoperative PT/SS-3.315*PT/SS at follow-up. On the basis of ROC curve, if PJK index was smaller and larger than − 2, the occurrence rate of PJK and non-PJK was 82 and 95%, respectively.

Conclusions

Preoperative TLK, LL at follow-up, preoperative PT/SS and PT/SS at follow-up were primary factors for PJK. PJK index could be used to predict occurrence of PJK effectively.

Graphical abstract

These slides can be retrieved under Electronic Supplementary Material.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ames CP, Scheer JK, Lafage V, Smith JS, Bess S, Berven SH, Mundis GM, Sethi RK, Deinlein DA, Coe JD, Hey LA, Daubs MD (2016) Adult spinal deformity: epidemiology, health impact, evaluation, and management. Spine Deform 4:310–322. https://doi.org/10.1016/j.jspd.2015.12.009

    Article  PubMed  Google Scholar 

  2. Carter OD, Haynes SG (1987) Prevalence rates for scoliosis in US adults: results from the first National Health and Nutrition Examination Survey. Int J Epidemiol 16:537–544

    Article  PubMed  CAS  Google Scholar 

  3. Sciubba DM, Yurter A, Smith JS, Kelly MP, Scheer JK, Goodwin CR, Lafage V, Hart RA, Bess S, Kebaish K, Schwab F, Shaffrey CI, Ames CP (2015) A comprehensive review of complication rates after surgery for adult deformity: a reference for informed consent. Spine Deform 3:575–594. https://doi.org/10.1016/j.jspd.2015.04.005

    Article  PubMed  Google Scholar 

  4. Nicholls FH, Bae J, Theologis AA, Eksi MS, Ames CP, Berven SH, Burch S, Tay BK, Deviren V (2017) Factors associated with the development of and revision for proximal junctional kyphosis in 440 consecutive adult spinal deformity patients. Spine. https://doi.org/10.1097/brs.0000000000002209

    Article  PubMed  Google Scholar 

  5. Lee GA, Betz RR, Clements DH 3rd, Huss GK (1999) Proximal kyphosis after posterior spinal fusion in patients with idiopathic scoliosis. Spine 24:795–799

    Article  PubMed  CAS  Google Scholar 

  6. Kim DK, Kim JY, Kim DY, Rhim SC, Yoon SH (2017) Risk factors of proximal junctional kyphosis after multilevel fusion surgery: more than 2 years follow-up data. J Korean Neurosurg Soc 60:174–180. https://doi.org/10.3340/jkns.2016.0707.014

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sebaaly A, Riouallon G, Obeid I, Grobost P, Rizkallah M, Laouissat F, Charles YP, Roussouly P (2017) Proximal junctional kyphosis in adult scoliosis: comparison of four radiological predictor models. Eur Spine J. https://doi.org/10.1007/s00586-017-5172-x

    Article  PubMed  Google Scholar 

  8. Yagi M, Akilah KB, Boachie-Adjei O (2011) Incidence, risk factors and classification of proximal junctional kyphosis: surgical outcomes review of adult idiopathic scoliosis. Spine 36:E60–E68. https://doi.org/10.1097/BRS.0b013e3181eeaee2

    Article  PubMed  Google Scholar 

  9. Raman T, Miller E, Martin CT, Kebaish KM (2017) The effect of prophylactic vertebroplasty on the incidence of proximal junctional kyphosis and proximal junctional failure following posterior spinal fusion in adult spinal deformity: a 5-year follow-up study. Spine J. https://doi.org/10.1016/j.spinee.2017.05.017

    Article  PubMed  Google Scholar 

  10. Lafage R, Schwab F, Glassman S, Bess S, Harris B, Sheer J, Hart R, Line B, Henry J, Burton D, Kim H, Klineberg E, Ames C, Lafage V (2017) Age-adjusted alignment goals have the potential to reduce PJK. Spine 42:1275–1282. https://doi.org/10.1097/brs.0000000000002146

    Article  PubMed  Google Scholar 

  11. Scheer JK, Osorio JA, Smith JS, Schwab F, Lafage V, Hart RA, Bess S, Line B, Diebo BG, Protopsaltis TS, Jain A, Ailon T, Burton DC, Shaffrey CI, Klineberg E, Ames CP (2016) Development of validated computer-based preoperative predictive model for proximal junction failure (PJF) or clinically significant PJK with 86% accuracy based on 510 ASD patients with 2-year follow-up. Spine 41:E1328–e1335. https://doi.org/10.1097/brs.0000000000001598

    Article  PubMed  Google Scholar 

  12. Kim HJ, Iyer S (2016) Proximal junctional kyphosis. J Am Acad Orthop Surg 24:318–326. https://doi.org/10.5435/jaaos-d-14-00393

    Article  PubMed  Google Scholar 

  13. Liu FY, Wang T, Yang SD, Wang H, Yang DL, Ding WY (2016) Incidence and risk factors for proximal junctional kyphosis: a meta-analysis. Eur Spine J 25:2376–2383. https://doi.org/10.1007/s00586-016-4534-0

    Article  PubMed  Google Scholar 

  14. Linden A (2006) Measuring diagnostic and predictive accuracy in disease management: an introduction to receiver operating characteristic (ROC) analysis. J Eval Clin Pract 12:132–139. https://doi.org/10.1111/j.1365-2753.2005.00598.x

    Article  PubMed  Google Scholar 

  15. Luo M, Wang P, Wang W, Shen M, Xu G, Xia L (2017) Upper thoracic versus lower thoracic as site of upper instrumented vertebrae for long fusion surgery in adult spinal deformity: a meta-analysis of proximal junctional kyphosis. World Neurosurg 102:200–208. https://doi.org/10.1016/j.wneu.2017.02.126

    Article  PubMed  Google Scholar 

  16. Lonner BS, Ren Y, Newton PO, Shah SA, Samdani AF, Shufflebarger HL, Asghar J, Sponseller P, Betz RR, Yaszay B (2017) Risk factors of proximal junctional kyphosis in adolescent idiopathic scoliosis-the pelvis and other considerations. Spine Deform 5:181–188. https://doi.org/10.1016/j.jspd.2016.10.003

    Article  PubMed  Google Scholar 

  17. Scemama C, Laouissat F, Abelin-Genevois K, Roussouly P (2017) Surgical treatment of thoraco-lumbar kyphosis (TLK) associated with low pelvic incidence. Eur Spine J 26:2146–2152. https://doi.org/10.1007/s00586-017-4984-z

    Article  PubMed  CAS  Google Scholar 

  18. Nasto LA, Perez-Romera AB, Shalabi ST, Quraishi NA, Mehdian H (2016) Correlation between preoperative spinopelvic alignment and risk of proximal junctional kyphosis after posterior-only surgical correction of Scheuermann kyphosis. Spine J 16:S26–S33. https://doi.org/10.1016/j.spinee.2015.12.100

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Li Li or Ming Li.

Ethics declarations

Conflict of interest

None of the authors have a conflict of interest.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PPTX 8055 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhao, J., Yang, M., Yang, Y. et al. Proximal junctional kyphosis in adult spinal deformity: a novel predictive index. Eur Spine J 27, 2303–2311 (2018). https://doi.org/10.1007/s00586-018-5514-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00586-018-5514-3

Keywords

Navigation