Skip to main content
SpringerLink
Log in

The effects of selenium nanoparticles (SeNPs) on oxidant and antioxidant activities and neonatal lamb weight gain pattern

  • Original Article
  • Published:
Comparative Clinical Pathology Aims and scope Submit manuscript

Abstract

Selenium (Se) is an antioxidant element that prevents the oxidative stress. Se incorporates into proteins such as selenocysteine and prevents oxidative damage to body tissues. In neonatal period, the different types of stress such as hypoglycemia and hypothermia may predispose them to many types of infectious diseases and also reduce growth rate at postnatal period. For these reasons, the present study was conducted on 12 newborn lambs to evaluate the effects of oral selenium nanoparticle (SeNP) supplementation on serum levels of selenium, copper, zinc, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) and catalase, and also weight gain changes during the first month of their life. Lambs were randomly divided into two groups. The treated group received SeNPs (0.1 mg/kg) and the control group received distilled water orally for seven consecutive days and the blood samples were taken on days 0, 7, 14, and 28. Results showed that in response to the 7-day SeNP administration and compared with the control group, serum selenium concentration was significantly increased, and serum copper and zinc levels were significantly decreased (P < 0.05). It was found that on day 14, TBARS activity was higher than that of the control group (P < 0.05). On day 28, the SOD level was increased compared with the control group and the TBARS activity decreased (P < 0.05). It was also shown that SeNP supplementation can significantly improve the weight gain of lambs on the 14th and 28th day. Overall, the results of the present study indicated the beneficial effects of SeNPs on antioxidant activity and weight gain patterns of newborn lambs which may promote lambs’ growth rate in postnatal period.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Battin EE, Brumaghim JL (2009) Antioxidant activity of sulfur and selenium: a review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms. Cell Biochem Biophys 55:1–23

    Article  CAS  Google Scholar 

  • Constable PD, Hinchcliff KW, Done SH, Grünberg W (2017) Veterinary medicine: a textbook of the diseases of cattle, horses, sheep, pigs and goats, 11th edn. Elsevier, St. Louis, Missouri

    Google Scholar 

  • Goth L (1991) A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 196:143–151

    Article  CAS  Google Scholar 

  • Heyland DK, Dhaliwal R, Suchner U, Berger MM (2005) Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med 31:327–337

    Article  Google Scholar 

  • Huang B, Zhang J, Hou J, Chen C (2003) Free radical scavenging efficiency of Nano-Se in vitro. Free Radic Biol Med 35:805–813

    Article  CAS  Google Scholar 

  • Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001) Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54:356–361

    Article  CAS  Google Scholar 

  • Kojouri GA, Faramarzi P, Ahadi AM, Parchami A (2013) Effect of selenium nanoparticles on expression of HSP90 gene in myocytes after an intense exercise. J Equine Vet Sci 33:1054–1056

    Article  Google Scholar 

  • Kojouri GA, Sadeghian S, Mohebbi A, Mokhber Dezfouli MR (2012) The effects of oral consumption of selenium nanoparticles on chemotactic and respiratory burst activities of neutrophils in comparison with sodium selenite in sheep. Biol Trace Elem Res 146:160–166

    Article  CAS  Google Scholar 

  • Kojouri GA, Shirazi A (2007) Serum concentrations of Cu, Zn, Fe, Mo and Co in newborn lambs following systemic administration of vitamin E and selenium to the pregnant ewes. Small Rumin Res 70:136–139

    Article  Google Scholar 

  • Kumar N, Garg AK, Mudgal V, Dass RS, Chaturvedi VK, Varshney VP (2008) Effect of different levels of selenium supplementation on growth rate, nutrient utilization, blood metabolic profile, and immune response in lambs. Biol Trace Elem Res 126:44–56

    Article  CAS  Google Scholar 

  • Larson CK (2005) Role of trace minerals in animal production: what do I need to know about trace minerals for beef and dairy cattle, horses, sheep and goats? Proceedings of the 2005 Tennessee Nutrition Conference.

  • Lawler TL, Taylor JB, Finley JW, Caton JS (2004) Effect of supranutritional and organically bound selenium on performance, carcass characteristics, and selenium distribution in finishing beef steers. J Anim Sci 82:1488–1493

    Article  CAS  Google Scholar 

  • Oldfield JE (1989) Selenium in animal nutrition: the Oregon and San Joaquin Valley (California) experiences--examples of correctable deficiencies in livestock. Biol Trace Elem Res 20:23–29

    Article  CAS  Google Scholar 

  • Paterson J, Swenson C, Johnson B, Ansotegui R (1999) Assessing the role of copper and zinc in the cow-calf production cycle. Proceedings of the 1999 Mid-South Ruminant Nutrition Conference.

  • Rael LT, Thomas GW, Craun ML, Curtis CG, Bar-Or R, Bar-Or D (2004) Lipid peroxidation and the thiobarbituric acid assay: standardization of the assay when using saturated and unsaturated fatty acids. J Biochem Mol Biol 37(6):749–752

    PubMed  CAS  Google Scholar 

  • Sadeghian S, Kojouri GA, Mohebi A (2012) Nanoparticles of selenium as species with stronger physiological effects in sheep in comparison with sodium selenite. Biol Trace Elem Res 146:302–308

    Article  CAS  Google Scholar 

  • Spears JW (2003) Trace mineral bioavailability in ruminants. J Nutr 133:1506–1509

    Article  Google Scholar 

  • Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497–500

    Article  CAS  Google Scholar 

  • Suttle NF (1975) Changes in the availability of dietary copper to young lambs with age and weaning. J Agric Sci 84:225–229

    Google Scholar 

  • Wang H, Zhang J, Yu H (2007) Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic Biol Med 42:1524–1533

    Article  CAS  Google Scholar 

  • Zhang JS, Gao XY, Zhang LD, Bao YP (2001) Biological effects of a nano red elemental selenium. Biofactors 15:27–38

    Article  Google Scholar 

  • Zhang J, Wang H, Bao Y, Zhang L (2004) Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci 75:237–244

    Article  CAS  Google Scholar 

  • Zhang CX, Yue WB, Dong WF (2007) Effect of nano-selenium on growth rate, enzyme of anti-oxidation, growth hormone and insulin concentration in goats. Acta Laser Biology Sinica 16:583–588

    CAS  Google Scholar 

  • Zhou X, Wang Y (2011) Influence of dietary nano elemental selenium on growth performance, tissue selenium distribution, meat quality, and glutathione peroxidase activity in Guangxi Yellow chicken. Poult Sci 90:680–686

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors would like to thank the directorate of postgraduate studies.

Funding

This study was financially sponsored by the Shahrekord University (Shahrekord, Iran).

Author information

Authors and Affiliations

  1. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, , P. O. Box 115, , Iran

    Gholamali Kojouri

  2. Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, , P. O. Box 115, , Iran

    Fatemeh Arbabi

  3. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, , P. O. Box 115, , Iran

    Abdolnaser Mohebbi

Authors
  1. Gholamali Kojouri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fatemeh Arbabi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Abdolnaser Mohebbi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gholamali Kojouri.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The experimental procedures carried out in this study complied with the guidelines of Shahrekord University (Shahrekord, Iran) for the care and use of animals. This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kojouri, G., Arbabi, F. & Mohebbi, A. The effects of selenium nanoparticles (SeNPs) on oxidant and antioxidant activities and neonatal lamb weight gain pattern. Comp Clin Pathol 29, 369–374 (2020). https://doi.org/10.1007/s00580-019-03061-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00580-019-03061-3

Keywords

Search

Navigation