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Atherosclerosis plaque area reduction: working hypothesis to prevent cardiovascular event

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Abstract

Cardiovascular events are the leading cause of death worldwide. In this sense, cardiovascular diseases (CVD) are the main products of atherosclerosis (ATR), whose origin is multifactorial. The measurable identification of the so-called cardiovascular risk factors (CRF) was a great advance for its prevention. Scientific evidences have shown that the reduction of mortality due to cardiovascular disease is an important achievement of the optimal control of CRF. However, a large proportion of patients have cardiovascular events when CRF is controlled. It is therefore imperative to stratify the patient’s risk in order to design the specific and individual treatment strategy. Currently, there are cardiovascular risk classification (CVR) scales that contemplate the combination of the multiple CRF that patients may present, although it is known that most of these algorithms sub- or overestimate the possibility of cardiovascular events. The incorporation of intermediate cardiovascular surrogates to CRF and events, such as the measurement of carotid atherosclerosis, is demonstrating an improvement in the diagnosis and fewer events in the healthy population, with high cardiovascular risk, treated with the incorporation of these to the diagnostic and therapeutic algorithms.

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Acknowledgements

The authors acknowledge CONICET, the Argentine Society of Arterial Hypertension, and Blossom DMO for their support in grants.

Funding

This study was funded by CONICET (grant numbers: Res4541/12 and PIP 2013-2015GI), the Argentine Society of Arterial Hypertension, and Blossom DMO.

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Authors and Affiliations

  1. Sanatorio Del Salvador Privado, Córdoba, X5004BCL, Argentina

    Hernán A. Perez

  2. Blossom DMO, Córdoba, X5000JHA, Argentina

    Hernán A. Perez

  3. Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina

    Gustavo Flores Allende

  4. DC&ONID, Biochemistry Department, Osun State University, Osogbo, Nigeria

    Ebenezer I. O. Ajayi

  5. IMMF-INIMEC-UNC, CONICET, Córdoba, X5016NST, Argentina

    Ebenezer I. O. Ajayi

  6. INICSA-UNC, CONICET, Córdoba, Argentina

    Daniela J. Porta & Néstor H. García

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  1. Hernán A. Perez
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  2. Gustavo Flores Allende
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  3. Ebenezer I. O. Ajayi
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  4. Daniela J. Porta
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  5. Néstor H. García
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Correspondence to Néstor H. García.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Perez, H.A., Allende, G.F., Ajayi, E.I.O. et al. Atherosclerosis plaque area reduction: working hypothesis to prevent cardiovascular event. Comp Clin Pathol 28, 907–914 (2019). https://doi.org/10.1007/s00580-018-2868-1

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