Abstract
The enzootic nasal tumor (ENT), a contagious tumor, is raised from the secretory epithelial cells of the ethmoid turbinate in animal which is caused by ENT virus type (ENTV) 2. The aim of this study is to investigate the clinical, radiological, and histopathological features of ENT or nasal adenocarcinoma in Lori-Bakhtiari breeds of goat. The affected goats showed respiratory nasal problems, continuous nasal exudate, and death resulted from progressive respiratory distress and anorexia. Dorsomedial radiographs of the skull region showed the mass in the right caudal paranasal sinus region deformation of bone in the near ethmoidal part. At necropsy, after dissection of the cranium through sagittal dorsomedial section, the presences of large unilateral tumor sessile masses with white, shiny, and soft like a gelatin form appearances were found. Acinar and papillary patterns were the most common histopathological finding in proliferated glands. The neoplastic cells were cuboidal or columnar with round or oval nuclei with very low mitotic index. This type of carcinoma originates from the serous gland cells in ethmoidal turbinate.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aydogan A, Haligur M, Ozmen O (2013) The expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE1/AE3 in goats with enzootic nasal adenocarcinoma: an immunohistochemical study. Vet Med 58(8):417–421
Chakraborty S, Kumar A, Tiwari R, Rahal A, Malik Y, Dhama K, Pal A, Prasad M (2014) Advances in diagnosis of respiratory diseases of small ruminants. Vet Med Int 2014:508304. https://doi.org/10.1155/2014/508304
Cousens C, Minguijon E, Garcia M, Ferrer LM, Dalziel RG, Palmarini M, de las Heras M, Sharp JM (1996) PCR-based detection and partial characterization of a retrovirus associated with contagious intranasal tumors of sheep and goats. J Virol 70(11):7580–7583
De las Heras M, Garcia de Jalon JA, Sharp JM (1991) Pathology of enzootic intranasal tumor in thirty-eight goats. J Vet Pathol 28(6):474–481. https://doi.org/10.1177/030098589102800603
De las Heras M, Garcia de Jalon JA, Minguijon E, Gray EW, Dewar P, Sharp JM (1995) Experimental transmission of enzootic intranasal tumors of goats. J Vet Pathol 32(1):19–23. https://doi.org/10.1177/030098589503200103
De las Heras M, Ortín A, Cousens C, Minguijon E, Sharp JM (2003) Enzootic nasal adenocarcinoma of sheep and goats. J Curr Top Microbiol Immunol 275:201–223
Dirks C, Duh FM, Rai SK, Lerman MI, Miller AD (2002) Mechanism of cell entry and transformation by enzootic nasal tumor virus. JVI 76(5):2141–2149. https://doi.org/10.1128/jvi.76.5.2141-2149.2002
Hindson JC, Winter AC (2002) Respiratory disease. In: Manual of sheep diseases, 2nd edn. Blackwell Science, Oxford, pp 196–209
Kane Y, Rosati S, Diop OM, Profiti I, Niang I, Kadja M et al (2005) Tissue targets and phylogenetic characteristic of the enzootic nasal tumour virus (ENTV) infecting sahelian sheep. Rev Med Vet 156:29–36
Lopez A (2012) Respiratory system, mediastinum, and pleurae. In: Zachary FJ, McGavin MD (eds) Pathologic basis of veterinary disease, 5th edn. Mosby-Elsevier Inc, St. Louis, pp 458–476
MacLachlan NJ, Dubovi EJ (2011) Retroviridae. In: Fenner’s veterinary virology, 4th edn. Academic Press is an imprint of Elsevier, pp 257
McKinnon AO, Thorsen J, Hayes MA, Misener CR (1982) Enzootic nasal adenocarcinoma of sheep in Canada. Can Vet J 23(3):88–94
Ortin A, Cousens C, Minguijon E, Pascual Z, Villarreal MP, Sharp JM et al (2003) Characterization of enzootic nasal tumour virus of goats: complete sequence and tissue distribution. J Gen Virol 84(Pt 8):2245–2252. https://doi.org/10.1099/vir.0.19125-0
Ozmen O, Sahinduran S, Haligur M, Demir N (2010) Clinical, pathological, immunohistochemical and ultrastructural observations on enzootic nasal adenocarcinoma in five goats. Kafkas Univ Vet Fak Derg 16(4):633–639
Rajan A, Sulochana S, Sreekumaran T, Reddi MV, Nair MK (1980) Tumors of the ethmoid mucosa in goats (Capra Hhircus). Indian J Cancer 17(3):196–199
Scocco P, Mariotti F, Ceccarelli P, Fagioli O, Renzoni G, Vitellozzi G (2001) Origin of enzootic intranasal tumor in the goat (Capra hircus): a glycohistochemical approach. Vet Pathol 38(1):98–104. https://doi.org/10.1354/vp.38-1-98
Scott PR (2011) Treatment and control of respiratory disease in sheep. Vet Clin N Am Food Anim Pract 27(1):175–186. https://doi.org/10.1016/j.cvfa.2010.10.016
Sharp JM, De las Heras M (2000) Contagious respiratory tumours. In: Martin WB, Aitken ID (eds) Diseases of sheep, 3rd edn. Blackwell Science, Oxford, pp 184–186
Stowe DM, Anderson KL, Guy JS, Linder KE, Grindem CB (2012) A case of enzootic nasal adenocarcinoma in a ewe. J Vet Med 2012:1–4
Svara T, Gombac M, Vrecl M, Juntes P, Pogacnik M, Gombac M et al (2006) Enzootic nasal adenocarcinoma of sheep. J Slov Vet Res 43(2):71–75
Tuttle LE, Grier RL (1985) Nasal adenocarcinoma in the canine. Iowa State Univ Vet 47(1):41–45
Vitellozzi G, Mughetti L, Palmarini M, Mandara MT, Mechelli L, Sharp JM et al (1993) Enzootic intranasal tumour of goats in Italy. Zentralbl Veterinar Med B 40:459–468
Walsh SR, Linnerth-Petrik NM, Laporte AN, Menzies PI, Foster RA, Wootton SK (2010) Full-length genome sequence analysis of enzootic nasal tumor virus reveals an unusually high degree of genetic stability. J Virus Res 151(1):74–87. https://doi.org/10.1016/j.virusres.2010.04.002
Walsh SR, Linnerth-Petrik NM, Yu DL, Foster RA, Menzies PI, Diaz-Méndez A et al (2013) Experimental transmission of enzootic nasal adenocarcinoma in sheep. Vet Res:44–66
Weinreb I (2010) Low grade glandular lesions of the sinonasal tract: a focused review. Head Neck Pathol 4(1):77–83. https://doi.org/10.1007/s12105-009-0159-5
Wilson DW, Dungworth DL (2002) Tumors of the respiratory tract. In: Meuten DJ (ed) Tumors in the domestic animals, 4th edn. Iowa State Press, Iowa, pp 374–375
Yi G, Kaiyu W, Qigui Y, Zhongqiong Y, Yingdong Y, Defang C, Jinlu H (2010) Descriptive study of enzootic nasal adenocarcinoma in goats in southwestern China. Transbound Emerg Dis 57(3):197–200. https://doi.org/10.1111/j.1865-1682.2010.01097.x
Yu DL, Linnerth-Petrik NM, Halbert CL, Walsh SR, Miller AD, Wootton SK (2011) Jaagsiekte sheep retrovirus and enzootic nasal tumor virus promoters drive gene expression in all airway epithelial cells of mice but only induce tumors in the alveolar region of the lungs. J Virol 85(15):7535–7545. https://doi.org/10.1128/JVI.00400-11
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All of the ethical issues and also applicable international, national, and/or institutional guidelines were addressed throughout the study. In addition, this article does not contain any studies with animals performed by any of the authors and does not contain any studies with human participants or animals performed by any of the authors.
Rights and permissions
About this article
Cite this article
Namjou, A., Shirian, S., Karimi, I. et al. Clinical and pathological findings of enzootic nasal adenocarcinoma of goat. Comp Clin Pathol 27, 539–543 (2018). https://doi.org/10.1007/s00580-018-2643-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00580-018-2643-3