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Association between treatment-related early changes in psychological factors and development of postherpetic neuralgia

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Abstract

Purpose

To examine the association between catastrophizing and pain intensity with acute herpes zoster, and the association of treatment-related early changes in depressive symptoms, anxiety, and catastrophizing with postherpetic neuralgia (PHN) development, independent of acute pain intensity.

Methods

We analyzed 44 outpatient participants with acute herpes zoster who completed a 6-month follow-up. Participants completed a self-reported questionnaire with a Visual Analog Scale (VAS), the Pain Catastrophizing Scale (PCS), and the Hospital Anxiety and Depression Scale (HADS) at first visit, and 3 and 6 months, thereafter. We assessed associations between acute pain intensity and analyzed factors using univariate regression analyses. Univariate and bivariate logistic regression models were constructed to assess associations of variables at the first visit and early changes in psychological factors with PHN development.

Results

Sex, severe skin rash at first visit, PCS, and HADS depression were associated with acute pain intensity {standardized regression coefficient, 0.46 [95% confidence interval (CI) 0.12–0.74], 0.36 (95% CI 0.07–0.65), 0.33 (95% CI 0.03–0.62), 0.47 (95% CI 0.19–0.74), respectively}. Acute pain intensity and early change in pain intensity were associated with PHN development [odds ratio (OR) 1.08 (95% CI 1.02–1.14) OR 2.38 (95% CI 1.10–5.16), respectively]. Decreased PCS was associated with decreased risk of PHN development, independent of acute pain intensity [OR 0.31 (95% CI: 0.12–0.80)].

Conclusion

Catastrophizing was associated with acute pain intensity, and lower pain-related catastrophizing among patients with acute herpes zoster was associated with less risk of PHN development, independent of acute pain intensity.

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Acknowledgements

We thank Benjamin Knight, MSc, and Jane Charbonneau, DVM, from Edanz Group (https://www.edanzediting.com/ac) for editing drafts of this manuscript.

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Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Rie Koga, Keiko Yamada, Rie Ishikawa & Masako Iseki

  2. Department of Anesthesiology and Pain Medicine, Sada Hospital, Fukuoka, Japan

    Rie Koga

  3. Department of Psychology, McGill University, Montreal, QC, Canada

    Keiko Yamada

  4. Department of Anesthesiology and Pain Medicine, Hachinohe Heiwa Hospital, Hachinohe, Aomori, Japan

    Rie Ishikawa

  5. Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan

    Yasuhiko Kubota

  6. Department of Anesthesiology and Pain Clinic, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan

    Keisuke Yamaguchi

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  1. Rie Koga
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  2. Keiko Yamada
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  3. Rie Ishikawa
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Correspondence to Keiko Yamada.

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Koga, R., Yamada, K., Ishikawa, R. et al. Association between treatment-related early changes in psychological factors and development of postherpetic neuralgia. J Anesth 33, 636–641 (2019). https://doi.org/10.1007/s00540-019-02679-5

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  • DOI: https://doi.org/10.1007/s00540-019-02679-5

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