Abstract
Purpose
Prescribing guideline-recommended anti-emetics is an effective strategy to prevent CINV. However, the rate of guideline-concordant care is not well-understood. The purpose of this study was to describe the proportion of pediatric, adolescent, and young adult patients receiving HEC or MEC who received guideline-concordant antiemetic prophylaxis for acute CINV and to identify potential predictors of guideline-concordant antiemetic prophylaxis.
Methods
Using electronic health record data from 2016 through 2018, a retrospective single-institution cohort study was conducted to investigate how often patients less than 26 years of age receiving moderately or highly emetogenic chemotherapy receive guideline-concordant prophylaxis for acute CINV. Guideline-concordant care was defined according to guidelines from the Pediatric Oncology Group of Ontario for patients < 18 years and the American Society of Clinical Oncology for those ≥ 18 years. Independent variables included: sex, age, insurance status, race, ethnicity, cancer type, chemotherapy regimen, clinical setting, chemotherapy emetogenicity, and patient location. Predictors of receiving guideline-concordant care were determined using multiple logistic regression.
Results
Of 180 eligible patients, 65 (36.1%) received guideline-concordant care. In multivariable analysis, being treated in adult oncology setting (aOR 14.3, CI95 5.3–38.6), with a cisplatin-based regimen (aOR 3.5, CI951.4–9.0), solid tumor diagnosis (aOR 2.2, CI95 1.0–4.8), and commercial insurance (aOR 2.4, CI95 1.1–5.2) were associated with significantly higher likelihood of receiving guideline-concordant care.
Conclusions
Multi-level factors were associated with receiving guideline concordant care for prevention of CINV in children, adolescents, and young adults receiving emetogenic chemotherapy. These findings can inform current efforts to optimize implementation strategies for supportive care guidelines.
Similar content being viewed by others
References
Multinational Association of Supportive Care in Cancer. https://www.mascc.org/about-mascc. https://www.mascc.org/about-mascc. Accessed January, 2019
Lorusso D, Bria E, Costantini A, Di Maio M, Rosti G, Mancuso A. (2017) Patients’ perception of chemotherapy side effects: expectations, doctor-patient communication and impact on quality of life - an Italian survey. European Journal of Cancer Care. 26(2):n/a-n/a
Baggott CR (2009) Children’s perspectives on symptoms and health related quality of life during cancer chemotherapy. University of California, San Francisco
Rodgers C, Kollar D, Taylor O, Bryant R, Crockett K, Gregurich MA, Hockenberry M (2012) Nausea and vomiting perspectives among children receiving moderate to highly emetogenic chemotherapy treatment. Cancer Nurs 35(3):203–210
Sun CC, Bodurka DC, Weaver CB, Rasu R, Wolf JK, Bevers MW, Smith JA, Wharton JT, Rubenstein EB (2005) Rankings and symptom assessments of side effects from chemotherapy: insights from experienced patients with ovarian cancer. Support Care Cancer : official journal of the Multinational Association of Supportive Care in Cancer 13(4):219–227
Baggott C, Dodd M, Kennedy C, Marina N, Matthay KK, Cooper BA, Miaskowski C (2010) Changes in children’s reports of symptom occurrence and severity during a course of myelosuppressive chemotherapy. J Ped Oncol Nurs : official journal of the Association of Pediatric Oncology Nurses 27(6):307–315
Dupuis LL, Boodhan S, Sung L, Portwine C, Hain R, McCarthy P, Holdsworth M, Pediatric Oncology Group of Ontario (2011) Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer 57(2):191–198
Hesketh PJ, Kris MG, Basch E, et al. (2017) Antiemetics: American Society of Clinical Oncology clinical practice guideline update. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Jco2017744789
Dupuis LL, Boodhan S, Holdsworth M, Robinson PD, Hain R, Portwine C, O’Shaughnessy E, Sung L, Pediatric Oncology Group of Ontario (2013) Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer 60(7):1073–1082
Hesketh PJ, Bohlke K, Lyman GH, Basch E, Chesney M, Clark-Snow RA, Danso MA, Jordan K, Somerfield MR, Kris MG, American Society of Clinical Oncology (2016) Antiemetics: American Society of Clinical Oncology focused guideline update. J Clin Oncol 34(4):381–386
Basch E, Prestrud AA, Hesketh PJ, Kris MG, Feyer PC, Somerfield MR, Chesney M, Clark-Snow RA, Flaherty AM, Freundlich B, Morrow G, Rao KV, Schwartz RN, Lyman GH, American Society of Clinical Oncology (2011) Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol : official journal of the American Society of Clinical Oncology 29(31):4189–4198
Flank J, Dupuis LL (2014) Comparative effectiveness research in antineoplastic-induced nausea and vomiting control in children. J Comp Eff Res 3(2):185–196
Gilmore JW, Peacock NW, Gu A et al (2014) Antiemetic guideline consistency and incidence of chemotherapy-induced nausea and vomiting in US community oncology practice: INSPIRE study. J Oncol Pract 10(1):68–74
Aapro M, Molassiotis A, Dicato M, Peláez I, Rodríguez-Lescure Á, Pastorelli D, Ma L, Burke T, Gu A, Gascon P, Roila F, PEER investigators (2012) The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER). Ann Oncol : official journal of the European Society for Medical Oncology 23(8):1986–1992
Patel P, Robinson PD, Orsey A, Freedman JL, Langevin AM, Woods D, Sung L, Dupuis LL (2016) Chemotherapy-induced nausea and vomiting prophylaxis: practice within the children’s oncology group. Pediatr Blood Cancer 63(5):887–892
Stacey D, Carley M, Ballantyne B, Skrutkowski M, Whynot A (2015) Perceived factors influencing nurses’ use of evidence-informed protocols for remote cancer treatment-related symptom management: a mixed methods study. Eur J Oncol Nurs : the official journal of European Oncology Nursing Society 19(3):268–277
Jun J, Kovner CT, Stimpfel AW (2016) Barriers and facilitators of nurses’ use of clinical practice guidelines: an integrative review. Int J Nurs Stud 60:54–68
Van Laar ES, Desai JM, Jatoi A (2015) Professional educational needs for chemotherapy-induced nausea and vomiting (CINV): multinational survey results from 2388 health care providers. Support Care Cancer 23(1):151–157
Loeffen EA, Kremer LC, Mulder RL, Font-Gonzalez A, Dupuis LL, Sung L, Robinson PD, van de Wetering M, Tissing WJE (2017) The importance of evidence-based supportive care practice guidelines in childhood cancer-a plea for their development and implementation. Support Care Cancer : official journal of the Multinational Association of Supportive Care in Cancer 25(4):1121–1125
Institute of Medicine. Clinical Practice Guidelines We Can Trust. 2011
Reilly CM, Bruner DW, Mitchell SA, Minasian LM, Basch E, Dueck AC, Cella D, Reeve BB (2013) A literature synthesis of symptom prevalence and severity in persons receiving active cancer treatment. Support Care Cancer : official journal of the Multinational Association of Supportive Care in Cancer 21(6):1525–1550
Hockenberry MJ, Hooke MC, Gregurich M, McCarthy K, Sambuco G, Krull K (2010) Symptom clusters in children and adolescents receiving cisplatin, doxorubicin, or ifosfamide. Oncol Nurs Forum 37(1):E16–E27
Holdsworth MT, Raisch DW, Frost J (2006) Acute and delayed nausea and emesis control in pediatric oncology patients. Cancer. 106(4):931–940
Flank J, Nadeem K, Moledina S, et al. (2017) Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: a prospective, observational study. Pediatric blood & cancer. 64(10)
Ettinger DS, Armstrong DK, Barbour S, Berger MJ, Bierman PJ, Bradbury B, Ellis G, Kirkegaard S, Kloth DD, Kris MG, Lim D, Michaud LB, Nabati L, Noonan K, Rugo HS, Siler D, Sorscher SM, Stelts S, Stucky-Marshall L, Todaro B, Urba SG, National Comprehensive Cancer Network (2012) Antiemesis. J Natl Compr Cancer Netw : JNCCN 10(4):456–485
Kris MG, Hesketh PJ, Somerfield MR et al (2006) American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006. J Clin Oncol 24(18):2932–2947
Check D, Reeder-Hayes K, Zullig L, Weinberger M, Basch EM, Dusetzina SB (2016) Examining racial variation in antiemetic use and post-chemotherapy health care utilization for nausea and vomiting among breast cancer patients. Support Care Cancer 24(12):4839–4847
Patel P, Robinson PD, Thackray J et al (2017) Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. Pediatr Blood Cancer
Morris ZS, Wooding S, Grant J (2011) The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med 104(12):510–520
Gomez DR, Liao KP, Giordano S, Nguyen H, Smith BD, Elting LS (2013) Adherence to national guidelines for antiemesis prophylaxis in patients undergoing chemotherapy for lung cancer: a population-based study. Cancer. 119(7):1428–1436
Check DK, Reeder-Hayes KE, Basch EM, Zullig LL, Weinberger M, Dusetzina SB (2016) Investigating racial disparities in use of NK1 receptor antagonists to prevent chemotherapy-induced nausea and vomiting among women with breast cancer. Breast Cancer Res Treat 156(2):351–359
Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR (1999) Why don’t physicians follow clinical practice guidelines? A framework for improvement. Jama. 282(15):1458–1465
Pound CM, Clark C, Ni A, Athale U, Lewis V, Halton JM (2012) Corticosteroids, behavior, and quality of life in children treated for acute lymphoblastic leukemia; a multicentered trial. J Pediatr Hematol Oncol 34(7):517–523
Roth P, Happold C, Weller M (2015) Corticosteroid use in neuro-oncology: an update. Neuro-oncology practice 2(1):6–12
Dupuis LL, Nathan PC (2010) Optimizing emetic control in children receiving antineoplastic therapy. Pediatr Drugs 12(1):51–61
Patel P, Leeder JS, Piquette-Miller M, Dupuis LL (2017) Aprepitant and fosaprepitant drug interactions: a systematic review. Br J Clin Pharmacol 83(10):2148–2162
Ruggiero A, Rizzo D, Catalano M, Coccia P, Triarico S, Attiná G (2018) Acute chemotherapy-induced nausea and vomiting in children with cancer: still waiting for a common consensus on treatment. J Int Med Res 46(6):2149–2156
Agency for Healthcare Research and Quality. (2018)Race, ethnicity, and language data: standardization for health care quality improvement. https://www.ahrq.gov/research/findings/final-reports/iomracereport/reldata1.html. Published. Accessed April, 2019
Crossing the quality chasm: a new health system for the 21st Century. [press release]. Washington, DC: The National Academies Press2001
Powell BJ, Waltz TJ, Chinman MJ et al (2015) A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implement Sci : IS 10:21
Mitchell SA, Chambers DA. (2017) Leveraging implementation science to improve cancer care delivery and patient outcomes. J Oncol Pract. Jop2017024729
Wood M, Hall L, Hockenberry M, Borinstein S (2015) Improving adherence to evidence-based guidelines for chemotherapy-induced nausea and vomiting. J Ped Oncol Nursing : official journal of the Association of Pediatric Oncology Nurses 32(4):195–200
Barone A, Casey D, McKee AE, Reaman G (2019) Cancer drugs approved for use in children: Impact of legislative initiatives and future opportunities. Pediatr Blood Cancer 66:e27809
Avant D, Wharton GT, Murphy D (2018) Characteristics and changes of pediatric therapeutic trials under the best pharmaceuticals for children act. J Pediatr 192:8–12
McMahon AW, Dal PG (2018) Assessing drug safety in children - the role of real-world data. N Engl J Med 378(23):2155–2157
Funding
M.B. was supported by the Reducing Health Disparities through Informatics (RHeaDI) training grant (T32NR007969) funded by NINR, the Training Program in Cancer-Related Population Sciences (NCI T32 CA094061), and a Doctoral Degree Scholarship in Cancer Nursing, DSCN-18-068-01, from the American Cancer Society. R.S. was supported by the National Institute of Nursing Research of the National Institutes of Health under award number K24NR018621. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Beauchemin, M., Sung, L., Hershman, D.L. et al. Guideline concordant care for prevention of acute chemotherapy-induced nausea and vomiting in children, adolescents, and young adults. Support Care Cancer 28, 4761–4769 (2020). https://doi.org/10.1007/s00520-020-05310-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00520-020-05310-6