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Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma

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Abstract

Purpose

According to reports, patients with lung cancer have decreased pulmonary function and exercise capacity after surgery. However, to date, physical function and health-related quality of life (HRQOL) after surgery for malignant pleural mesothelioma (MPM) have not been evaluated in detail in the convalescent phase. This study aimed to assess physical function and HRQOL of MPM patients following pleurectomy/decortication (P/D) in the convalescent phase.

Methods

The study included 16 male MPM patients who underwent P/D between September 2014 and August 2016. Physical function was assessed based on handgrip and knee extensor strengths, the six-minute walk distance (6MWD), and pulmonary function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). HRQOL was assessed using the Medical Outcome Study 36-item Short Form Health Survey (SF-36). The assessment was performed preoperatively, postoperatively, and 1-year after surgery.

Results

The 6MWD, FVC, and FEV1 values 1-year postoperatively improved significantly compared with baseline (P < 0.05 all). Additionally, the scores of six of the eight SF-36 domains were significantly improved 1 year after P/D: physical functioning, body pain, general health, vitality, social functioning, and mental health (all P < 0.05). 6MWD, FVC, and FEV1 were correlated with vitality, mental health, and physical functioning (P < 0.05 all).

Conclusions

Patients with MPM who underwent P/D showed improved physical function and HRQOL compared with postoperative values in the convalescent phase. Physicians, nurses, and rehabilitation staff should note these findings, which may provide insight into the development of customized rehabilitation strategies in the convalescent phase for such patients.

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Acknowledgments

The authors are grateful to the study participants and the physiotherapists at the Rehabilitation Department and surgeons at the Department of Thoracic Surgery of the Hyogo College of Medicine Hospital. This study was supported in part by the Foundation for Promotion of Cancer Research in Japan.

Grant

This study was supported in part by the Foundation for Promotion of Cancer Research in Japan.

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Authors and Affiliations

  1. Department of Rehabilitation Medicine, Hyogo College of Medicine Hospital, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Takashi Tanaka

  2. Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan

    Shinichiro Morishita

  3. Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    Shinichiro Morishita, Yuki Uchiyama & Kazuhisa Domen

  4. Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan

    Masaki Hashimoto, Toru Nakamichi & Seiki Hasegawa

Authors
  1. Takashi Tanaka
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  2. Shinichiro Morishita
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  3. Masaki Hashimoto
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  4. Toru Nakamichi
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  5. Yuki Uchiyama
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  6. Seiki Hasegawa
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  7. Kazuhisa Domen
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Corresponding author

Correspondence to Takashi Tanaka.

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The study was approved by the Hyogo College of Medicine Institutional Committee on Human Research. Written informed consent was obtained from all participants.

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The authors declare that they have no conflict of interest.

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Tanaka, T., Morishita, S., Hashimoto, M. et al. Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma. Support Care Cancer 27, 4107–4113 (2019). https://doi.org/10.1007/s00520-019-04704-5

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  • DOI: https://doi.org/10.1007/s00520-019-04704-5

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