Skip to main content
Log in

Keine Evidenz für die Abschwächung der analgetischen Opioidwirkung durch peripher wirksame µ‑Opioidrezeptorantagonisten

Lack of evidence for the inhibition of opioid-related analgesia through peripherally acting μ‑opioid-receptor antagonists

  • Leserbriefe
  • Published:
Der Schmerz Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Stein C (2019) Schmerzinhibition durch Opioide – neue Konzepte. Schmerz 33:295–302

    Article  CAS  Google Scholar 

  2. Jagla CA, Martus P, Stein C (2014) Peripheral opioid receptor blockade increases postoperative morphine demands—a randomized, double-blind, placebo-controlled trial. Pain 155:2056–2062

    Article  CAS  Google Scholar 

  3. Chey WD, Webster L, Sostek M, Lappalainen J, Barker PN, Tack J (2014) Naloxegol for opioid-induced constipation in patients with noncancer pain. N Engl J Med 370(25):2387–2396

    Article  Google Scholar 

  4. Webster L, Chey WD, Tack J, Lappalainen J, Diva U, Sostek M (2014) Randomised clinical trial: the long-term safety and tolerability of naloxegol in patients with pain and opioid-induced constipation. Aliment Pharmacol Ther 40(7):771–779

    Article  CAS  Google Scholar 

  5. Webster L, Diva U, Tummala R, Sostek M (2018) Treatment with naloxegol versus placebo: pain assessment in patients with noncancer pain and opioid-induced constipation. Pain Pract 18(4):505–514

    Article  Google Scholar 

  6. Hale M, Wild J, Reddy J, Yamada T, Arjona Ferreira JC (2017) Naldemedine versus placebo for opioid-induced constipation (COMPOSE‑1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials. Lancet Gastroenterol Hepatol 2(8):555–564

    Article  Google Scholar 

  7. Katakami N, Harada T, Murata T, Shinozaki K, Tsutsumi M, Yokota T, Arai M, Tada Y, Narabayashi M, Boku N (2017) Randomized phase III and extension studies of naldemedine in patients with opioid-induced constipation and cancer. J Clin Oncol 35(34):3859–3866

    Article  CAS  Google Scholar 

  8. Firouzian A, Gholipour Baradari A, Alipour A, Emami Zeydi A, Zamani Kiasari A, Emadi SA, Kheradmand B, Hadadi K (2018) Ultra-low-dose naloxone as an adjuvant to patient controlled analgesia (PCA) with morphine for postoperative pain relief following lumber discectomy: a double-blind, randomized, placebo-controlled trial. J Neurosurg Anesthesiol 30(1):26–31

    Article  Google Scholar 

  9. Ueberall MA, Mueller-Schwefe GH (2015) Safety and efficacy of oxycodone/naloxone vs. oxycodone vs. morphine for the treatment of chronic low back pain: results of a 12 week prospective, randomized, open-label blinded endpoint streamlined study with prolonged-release preparations. Curr Med Res Opin 31(7):1413–1429

    Article  CAS  Google Scholar 

  10. Ueberall MA, Mueller-Schwefe GH (2015) Development of opioid-induced constipation: post hoc analysis of data from a 12-week prospective, open-label, blinded-endpoint streamlined study in low-back pain patients treated with prolonged-release WHO step III opioids. J Pain Res 8:459–475

    Article  Google Scholar 

  11. Ueberall MA, Eberhardt A, Mueller-Schwefe GH (2016) Quality of life under oxycodone/naloxone, oxycodone, or morphine treatment for chronic low back pain in routine clinical practice. Int J Gen Med 9:39–51

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Michael A. Überall or Gerhard H. H. Müller-Schwefe.

Ethics declarations

Interessenkonflikt

M.A. Überall und G.H.H. Müller-Schwefe geben an, dass kein Interessenkonflikt besteht.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Überall, M.A., Müller-Schwefe, G.H.H. Keine Evidenz für die Abschwächung der analgetischen Opioidwirkung durch peripher wirksame µ‑Opioidrezeptorantagonisten. Schmerz 34, 84–85 (2020). https://doi.org/10.1007/s00482-019-00427-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00482-019-00427-y

Navigation