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Serum glutathione S-transferase Pi as predictor of the outcome and acute kidney injury in premature newborns

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Abstract

Background

The incidence of acute kidney injury (AKI) among the neonates treated at the Neonatal Intensive Care Unit is high with high mortality rates. Glutathione S-transferase (GST) class Pi plays an important role in the protection of cells from cytotoxic and oncogenic agents. The aim of the study was to examine whether the levels of serum glutathione S-transferase Pi (GST Pi) determined after birth have any predictive value for the outcome and development of AKI in premature neonates.

Methods

The prospective study included 36 premature neonates. The data about morbidity was gathered for all the neonates included in the study. The blood samples were taken in the first 6 h of life and GST Pi levels were measured.

Results

The mean values and standard deviations of GST Pi among the neonates who died and who survived were 1.904 ± 0.4535 vs 1.434 ± 0.444 ng/ml (p = 0.0128). Logistic regression revealed a statistically significant, positive correlation between GST Pi levels and death (p = 0.0180, OR7.5954; CI 1.4148–40.7748).The mean value of GST Pi levels in the neonates with AKI was higher than in neonates without AKI (p = 0.011).

Conclusions

The conclusion of our study is that high levels of serum GST Pi in the first 6 h after birth are associated with an increased mortality and development of AKI in prematurely born neonates.

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Abbreviations

AKI:

Acute kidney injury

GST:

Glutathione S-transferase

pO2 :

Partial pressure of oxygen

NICU:

Neonatal Intensive Care Units

SCr:

Serum creatinine

AKIN:

Acute Kidney Injury Network

UOP:

Urine output

GA:

Gestational age

BW:

Birth weight

FiO2 :

Fraction of inspired oxygen

ICH:

Intracranial hemorrhage

EOS:

Early-onset sepsis

GFR:

Glomerular filtration rate (GFR)

NGAL:

Neutrophil gelatinase-associated lipocalin

KIM-1:

Kidney injury molecule-1

IL-18:

Interleukin 18

DNA:

Deoxyribonucleic acid

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Authors and Affiliations

  1. School of Medicine, Institute for Child and Youth Health Care of Vojvodina, NICU/PICU, University of Novi Sad, Hajduk Veljkova 10, Novi Sad, 21000, Serbia

    Vesna D. Stojanović, Nenad A. Barišić & Aleksandra D. Doronjski

  2. Institute for Child and Youth Health Care of Vojvodina, NICU/PICU, Novi Sad, Serbia

    Tanja D. Radovanović & Nataša B. Kovač

  3. Laboratory for Medical Biochemistry Medlab, Novi Sad, Serbia

    Jelena D. Djuran

  4. University Children Hospital, Belgrade, Serbia

    Amira Peco E. Antić

Authors
  1. Vesna D. Stojanović
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  2. Nenad A. Barišić
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  3. Tanja D. Radovanović
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  4. Nataša B. Kovač
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  5. Jelena D. Djuran
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  6. Amira Peco E. Antić
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  7. Aleksandra D. Doronjski
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Corresponding author

Correspondence to Vesna D. Stojanović.

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Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all the individual participants included in the study.

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Stojanović, V.D., Barišić, N.A., Radovanović, T.D. et al. Serum glutathione S-transferase Pi as predictor of the outcome and acute kidney injury in premature newborns. Pediatr Nephrol 33, 1251–1256 (2018). https://doi.org/10.1007/s00467-018-3910-x

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  • DOI: https://doi.org/10.1007/s00467-018-3910-x

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