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Association between allergic disease, sleep-disordered breathing, and childhood nocturnal enuresis: a population-based case-control study

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Abstract

Background

Little is known about the associations between allergic disease, sleep-disordered breathing (SDB), and childhood nocturnal enuresis (NE). We examined whether allergic disease and SDB were associated with childhood NE.

Methods

Data were assessed from the 2007–2012 Taiwan National Health Insurance Research Database. We enrolled 4308 children aged 5–18 years having NE diagnosis and age- and sex-matched 4308 children as the control group. The odds ratios of NE were calculated to determine an association with preexisting allergic disease and SDB.

Results

A total of 8616 children were included in the analysis. Prevalence of allergic diseases and SDB was significantly higher for the NE group than the control group (all p < 0.001). After adjusting odds ratios for potential confounding factors, except asthma, children with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and obstructive sleep apnea (OSA) had significantly higher odds of NE compared with children never diagnosed. With stratification for sex, girls with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, OSA, and snoring had significantly higher odds of NE, compared with girls never diagnosed. Only boys with allergic rhinitis and OSA were associated with increased odds of NE. With stratification for age, children aged 5–12 years with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and OSA had significantly higher odds of NE compared with those never diagnosed. Odds of NE increased with the number of comorbid allergic diseases.

Conclusions

Allergic diseases and SDB are associated with increased odds of childhood NE. The odds of NE increased with the number of comorbid allergic diseases present.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan

    Jeng-Dau Tsai, Min-Sho Ku, Shan-Ming Chen & Ji-Nan Sheu

  2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Jeng-Dau Tsai, Min-Sho Ku, Shan-Ming Chen & Ji-Nan Sheu

  3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    Hsuan-Ju Chen

  4. College of Medicine, China Medical University, Taichung, Taiwan

    Hsuan-Ju Chen

  5. Department of Pediatrics, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan

    Chih-Chuan Hsu

  6. Department of Surgery, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan

    Min-Che Tung

  7. Healthcare Service Research Center, Taichung Veterans General Hospital, Taichung, Taiwan

    Che-Chen Lin

  8. Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan

    Hsing-Yi Chang

Authors
  1. Jeng-Dau Tsai
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  2. Hsuan-Ju Chen
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  3. Min-Sho Ku
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  6. Min-Che Tung
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Corresponding author

Correspondence to Ji-Nan Sheu.

Ethics declarations

The study was approved by the Institutional Ethics Committee at the Chung Shan Medical University Hospital (# CS14019).

Conflict of interest

The authors declare no conflicts of interest.

Funding/support

This study was supported in part by Chung Shan Medical University Hospital (CSH-2016-a-018), Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW106-TDU-B-212-113,004), China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10501010037), NRPB Stroke Clinical Trial Consortium (MOST 105–2325-B-039-003), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan.

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Tsai, JD., Chen, HJ., Ku, MS. et al. Association between allergic disease, sleep-disordered breathing, and childhood nocturnal enuresis: a population-based case-control study. Pediatr Nephrol 32, 2293–2301 (2017). https://doi.org/10.1007/s00467-017-3750-0

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  • DOI: https://doi.org/10.1007/s00467-017-3750-0

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