Abstract
Purpose
This study aimed to evaluate the clinical effects of percutaneous vertebroplasty (PVP) combined with postoperative radiotherapy (RT) in the treatment of spinal metastases.
Methods
Nine patients (4 males and 5 females, mean age 59.56 years) with painful pathologic compression vertebral fractures caused by metastatic cancers of the spine (5 thoracic levels, 8 lumbar levels) were admitted to our hospital between July 17, 2016 and September 25, 2018. All patients were treated with PVP via bilateral pedicle approach combined with postoperative RT to treat metastatic lesions of the centrum. The clinical records of the patients were retrospectively analyzed. Patients’ demographic features and medical conditions including the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI) and Imageology data were observed.
Results
Patients’ mean VAS scores decreased from 8.67 ± 0.50 preoperatively to 1.78 ± 0.83 at 6 months after PVP. Moreover, the mean ODI score decreased from 74.07 ± 13.15 preoperatively to 31.87 ± 10.00 at 6 months after PVP. Significant improvement in the degree of pain and dysfunction among the enrolled patients were observed. Furthermore, the metastatic carcinoma lesion within the vertebral body was well controlled according to imaging.
Conclusion
PVP in conjunction with postoperative RT is a good treatment strategy for vertebral compression fractures caused by metastases.
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Acknowledgements
Thanks for Xiaobing Yu conceived and designed the study.
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XY conceived and designed the study. MQ, TL and RD collected the data. WH and Miaoman Lin analysed and interpretated the data.Miaoman Lin analyzed the statistical and wrote the paper. Yashuai Yuan,Junxiao Gao,Meng Zhang and Xiaobing Yu reviewed and edited the manuscript. Mingjia Qu played a very important role in the revision of the manuscript.All authors read and approved the manuscript.
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Lin, M., Qu, M., Huang, W. et al. Clinical effectiveness of percutaneous vertebroplasty in conjunction with postoperative radiotherapy in the treatment of spinal metastases. J Cancer Res Clin Oncol 147, 835–844 (2021). https://doi.org/10.1007/s00432-020-03371-y
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DOI: https://doi.org/10.1007/s00432-020-03371-y