Abstract
Recent efforts in the area of photothermal therapy (PTT) follow two important aims: (i) selective targeting of plasmonic nanoparticles to the tumor and (ii) real-time guidance of PTT operation through employing multimodal imaging modalities. In the present study, we utilized a multifunctional theranostic nanoplatform constructed from iron (III) oxide–gold (Fe2O3@Au) core–shell nanoparticles to fulfill these aims. The Au shell exhibits surface plasmon resonance, a property that is exploited to realize PTT. The magnetic core enables Fe2O3@Au to be employed as a magnetic resonance imaging (MRI) contrast agent. Furthermore, the magnetic core has the potential to establish a magnetic drug targeting strategy through which Fe2O3@Au can be directed to the tumor site by means of magnetic field. To test these potentials, Balb/c mice bearing CT26 colorectal tumor model were intravenously injected with Fe2O3@Au. Immediately after injection, a magnet was placed on the tumor site for 3 h to concentrate nanoparticles, followed by the near infrared (NIR) laser irradiation. MRI study confirmed the accumulation of nanoparticles within the tumor due to T2 enhancement capability of Fe2O3@Au. The in vivo thermometry results demonstrated that the tumors in magnetic targeting group had a significantly higher temperature elevation rate upon NIR irradiation than non-targeted group (~ 12 °C vs. 8.5 °C). The in vivo antitumor assessment revealed that systemic injection of Fe2O3@Au in combination with magnetic targeting and NIR irradiation resulted in complete remission of tumor growth. Therefore, Fe2O3@Au can establish a targeted PTT strategy for efficient eradication of tumor cells under the guidance of MRI.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abadeer NS, Murphy CJ (2016) Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C 120:4691–4716
Bagher Z, Kamrava SK, Alizadeh R, Farhadi M, Absalan M, Falah M, Faghihi F, Zare-Sadegh A, Komeili A (2018) Differentiation of neural crest stem cells from nasal mucosa into motor neuron-like cells. J Chem Neuroanat 92:35–40
Beik J, Abed Z, Shakeri-Zadeh A, Nourbakhsh M, Shiran MB (2016) Evaluation of the sonosensitizing properties of nano-graphene oxide in comparison with iron oxide and gold nanoparticles. Physica E 81:308–314
Beik J, Khademi S, Attaran N, Sarkar S, Shakeri-Zadeh A, Ghaznavi H, Ghadiri H (2017) A nanotechnology-based strategy to increase the efficiency of cancer diagnosis and therapy: folate-conjugated gold nanoparticles. Curr Med Chem 24:4399–4416
Beik J, Shiran MB, Abed Z, Shiri I, Ghadimi-Daresajini A, Farkhondeh F, Ghaznavi H, Shakeri-Zadeh A (2018) Gold nanoparticle-induced sonosensitization enhances the antitumor activity of ultrasound in colon tumor-bearing mice. Med Phys 45:4306–4314
Chen J, Glaus C, Laforest R, Zhang Q, Yang M, Gidding M, Welch MJ, Xia Y (2010) Gold nanocages as photothermal transducers for cancer treatment. Small 6:811–817
Eustis S, El-Sayed MA (2006) Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. Chem Soc Rev 35:209–217
Eyvazzadeh N, Shakeri-Zadeh A, Fekrazad R, Amini E, Ghaznavi H, Kamrava SK (2017) Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer. Lasers Med Sci 32:1469–1477
Farashahi A, Zare-Sadeghi A, Shakeri-Zadeh A, Kamrava SK, Maleki S, Ghaznavi H, Faeghi F (2019) Real-time mapping of heat generation and distribution in a laser irradiated agar phantom loaded with gold nanoparticles using mr temperature imaging. Photodiagn Photodyn Therapy 25:66–73
Ghaznavi H, Hosseini-Nami S, Kamrava SK, Irajirad R, Maleki S, Shakeri-Zadeh A (2018) Folic acid conjugated PEG coated gold–iron oxide core–shell nanocomplex as a potential agent for targeted photothermal therapy of cancer. Artifi Cells Nanomed Biotechnol 46:1594–1604
Hashemian A, Eshghi H, Mansoori G, Shakeri-Zadeh A, Mehdizadeh A (2009) Folate-conjugated gold nanoparticles (synthesis, characterization and design for cancer cells nanotechnology-based targeting). Int J Nanosci Nanotechnol 5:25–34
Jain RK, Stylianopoulos T (2010) Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol 7:653–664
Maeda H, Wu J, Sawa T, Matsumura Y, Hori K (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 65:271–284
Manuchehrabadi N, Toughiri R, Bieberich C, Cai H, Attaluri A, Edziah R, Lalanne E, Johnson AM, Ma R, Zhu L (2013) Treatment efficacy of laser photothermal therapy using gold nanorods. Int J Biomed Eng Technol 12:157–176
Mirrahimi M, Hosseini V, Kamrava SK, Attaran N, Beik J, Kooranifar S, Ghaznavi H, Shakeri-Zadeh A (2018) Selective heat generation in cancer cells using a combination of 808 nm laser irradiation and the folate-conjugated Fe2O3@ Au nanocomplex. Artifi Cells Nanomed Biotechnol 46:241–253
Mirrahimi M, Abed Z, Beik J, Shiri I, Dezfuli AS, Mahabadi VP, Kamrava SK, Ghaznavi H, Shakeri-Zadeh A (2019) A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy. Pharmacol Res. https://doi.org/10.1016/j.phrs.2019.01.005
Qin Z, Bischof JC (2012) Thermophysical and biological responses of gold nanoparticle laser heating. Chem Soc Rev 41:1191–1217
Shakeri-Zadeh A, Eshghi H, Mansoori G, Hashemian A (2009) Gold nanoparticles conjugated with folic acid using mercaptohexanol as the linker. J Nanotechnol Progress Int 1:13–23
Shakeri-Zadeh A, Kamrava SK, Farhadi M, Hajikarimi Z, Maleki S, Ahmadi A (2014) A scientific paradigm for targeted nanophotothermolysis; the potential for nanosurgery of cancer. Lasers Med Sci 29:847–853
Tong L, Wei Q, Wei A, Cheng JX (2009) Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects. Photochem Photobiol 85:21–32
Zhao J, Wallace M, Melancon MP (2014) Cancer theranostics with gold nanoshells. Nanomedicine 9:2041–2057
Funding
This study was funded by Zahedan University of Medical Sciences (grant number 7970).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Abed, Z., Beik, J., Laurent, S. et al. Iron oxide–gold core–shell nano-theranostic for magnetically targeted photothermal therapy under magnetic resonance imaging guidance. J Cancer Res Clin Oncol 145, 1213–1219 (2019). https://doi.org/10.1007/s00432-019-02870-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00432-019-02870-x