Abstract
Neonates born to transplanted mothers are exposed to immunosuppressive drugs during gestation and have a higher risk of being born prematurely and small for gestational age than the general population. We have prospectively followed up 27 children born to renal transplanted mothers from a single center and 31 healthy children born at term with adequate weight for gestational age. Comparisons of weight and length measurements were made at birth, 1 month (±0.9), 3 months (±1.0), 6 months (±1.0), 9 months (±1.5), and 12 months (±1.49) of age. There were a high rate of prematurity (51.9%) and neonates small for gestational age (40.7%) in the transplant group. At birth, in the transplant group, 28% of neonates had subnormal z-scores for weight and 40%, low z-scores for length. However, at 6 months of age, no significant differences were noticed in mean weight-for-age z-scores between groups (weight −0.43 vs −0.03; length −0.53 vs −0.08). At 12 months of age, comparable mean length-for-age z-scores were observed in both groups (weight 0.01 vs 0.27; length −0.07 vs 0.26).
Conclusion: Despite high rates of premature births and neonates small for gestational age in the transplant group, there was a good recovery of growth during the first year..
What is Known: • Children born to renal transplanted mothers are exposed to immunosuppressive drugs during gestation [4]. • They have high risk of premature birth and fetal growth restriction, immune alterations at birth, and risk of hospitalization for infection in the first months of life [5]. |
What is New: • Despite high rates of premature birth and neonates small for gestational age, these infants had good growth recovery by 1 year of age. |
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Abbreviations
- CNT:
-
Control
- TX:
-
Transplant
- AGA:
-
Adequate for gestational age
- SGA:
-
Small for gestational age
- T:
-
Term
- PT:
-
Preterm
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Dr MISD contributed to the conception and design of the study, data collection and data analysis, drafted the initial manuscript and approved the final version of the manuscript. Dr EO contributed to data collection and data analysis and approved the final version of the manuscript. Dr POV contributed to data collection and data analysis and approved the final version of the manuscript. Dr AMNS contributed to the conception and design of the study, data analysis and critically reviewed the manuscript; she approved the final version of the manuscript. Dr MIMP contributed to the conception and design of the study, data analysis and critically reviewed the manuscript; she approved the final version of the manuscript.
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The source of funding for the research was FAPESP (Grant Number 2008/11670-9). The sponsor had no involvement in the study design, collection, analysis and interpretation of data; the writing; and the decision to submit the paper for publication.
This study was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil (Grant Number 2008/11670-9).
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The study protocol was approved by ethics committee of Federal University of Sao Paulo and a written informed consent was obtained from all participants prior to initiating study procedures.
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Communicated by Mario Bianchetti
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Dinelli, M.I.S., Ono, E., Viana, P.O. et al. Growth of children born to renal transplanted women. Eur J Pediatr 176, 1201–1207 (2017). https://doi.org/10.1007/s00431-017-2965-1
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DOI: https://doi.org/10.1007/s00431-017-2965-1