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Monozygotic twins concordant for idiopathic thrombocytopenic purpura and discordant for systemic lupus erythematosus and lupus nephritis

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Abstract

We report on identical twin sisters with systemic lupus erythematosus and lupus nephritis after initial presentation as idiopathic thrombocytopenic purpura. The patients had diverse clinical signs, symptoms and pathological findings of lupus nephritis. The changes in antinuclear antibodies and anti-double-stranded DNA antibodies were quite different. We conclude that even with an identical genetic background and the same environment, the expression of systemic lupus erythematosus and subsequent progression to lupus nephritis in twins was distinct, and antinuclear antibodies and anti-double-stranded DNA antibodies are helpful for clinical monitoring.

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Fig. 1
Fig. 2

Abbreviations

SLE:

systemic lupus erythematosus

LN:

lupus nephritis

ITP:

idiopathic thrombocytopenic purpura

CITP:

chronic idiopathic thrombocytopenic purpura

ANA:

antinuclear antibody

Anti-dsDNA:

anti-double-stranded DNA

HLA:

human leukocyte antigen

STR:

short tandem repeat

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Authors and Affiliations

  1. Department of Pediatrics, National Defense Medical Center, Taipei, Taiwan, Republic of China

    Wen-Chin Huang, Shao-Hung Lien & Shin-Nang Cheng

  2. Division of Rheumatology-Immunology-Allergy, Department of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China

    Deh-Ming Chang

  3. Division of Rheumatology-Immunology-Allergy, Department of Pathology, National Defense Medical Center, Taipei, Taiwan, Republic of China

    Jang-Jih Lu

  4. Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Rd., Sec. 2, Neihu, Taipei, 114, Taiwan, Republic of China

    Shin-Nang Cheng

Authors
  1. Wen-Chin Huang
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  2. Shao-Hung Lien
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  3. Deh-Ming Chang
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  4. Jang-Jih Lu
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  5. Shin-Nang Cheng
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Corresponding author

Correspondence to Shin-Nang Cheng.

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Huang, WC., Lien, SH., Chang, DM. et al. Monozygotic twins concordant for idiopathic thrombocytopenic purpura and discordant for systemic lupus erythematosus and lupus nephritis. Eur J Pediatr 166, 497–500 (2007). https://doi.org/10.1007/s00431-006-0266-1

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  • DOI: https://doi.org/10.1007/s00431-006-0266-1

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