Abstract
Malignancies rarely occur in somatic parts of mature cystic teratoma of the ovary. Squamous cell carcinoma is the most common form of cancer that can develop in mature cystic teratoma. Other less frequent malignancies include melanoma, sarcoma, carcinoid, and germ cell neoplasms. Only three cases have been reported as papillary thyroid carcinoma arising in struma ovarii. We present a unique case of a 31-year-old female patient who presented with a left ovarian cyst and underwent conservative surgical management in the form of cystectomy. Histopathological examination confirmed the diagnosis of a tall cell subtype of papillary thyroid carcinoma arising from a small focus of thyroid tissue in a mature cystic teratoma of the ovary. The patient was followed up for 60 months with an uneventful clinical course. For a better understanding of such rare cancers, collaborative retrospective studies on large databases with other medical centers are required.
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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Samir Al Bashir, Mohammed S. Alorjani, Husam K. Haddad, Mohammad I. Matalka, and Nail Obeidat. The first draft of the manuscript was written by Samir Al Bashir and Mohammed S. Alorjani, and all authors commented on previous versions of the manuscript. Ismail I. Matalka and Manuel Sobrinho-Simões reviewed the manuscript. All authors read and approved the final manuscript.
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Al Bashir, S., Alorjani, M.S., Haddad, H.K. et al. Mature cystic teratoma of the ovary with malignant transformation of tall cell subtype of papillary thyroid carcinoma. Virchows Arch 483, 251–254 (2023). https://doi.org/10.1007/s00428-023-03594-7
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DOI: https://doi.org/10.1007/s00428-023-03594-7