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Sodium chloride, SGK1, and Th17 activation

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Abstract

The incidence of autoimmune diseases in Western civilizations is increasing rapidly, suggesting an influence of environmental factors, such as diet. The pathogenesis of several of these autoimmune diseases is characterized by aberrant activation of T helper 17 (Th17) cells. Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1). In this review, we summarize the recently disclosed mechanisms by which salt has been shown to affect SGK1 and, subsequently, Th17 activation.

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Authors and Affiliations

  1. Experimental and Clinical Research Center, an institutional cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, Berlin, 13125, Germany

    Katrina J. Binger & Dominik N. Muller

  2. Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, 91054, Germany

    Ralf A. Linker

  3. Max-Delbrueck Center for Molecular Medicine, Berlin, 13125, Germany

    Dominik N. Muller

  4. Translational Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, 01307, Dresden, Germany

    Markus Kleinewietfeld

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  1. Katrina J. Binger
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  2. Ralf A. Linker
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Correspondence to Dominik N. Muller.

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Binger, K.J., Linker, R.A., Muller, D.N. et al. Sodium chloride, SGK1, and Th17 activation. Pflugers Arch - Eur J Physiol 467, 543–550 (2015). https://doi.org/10.1007/s00424-014-1659-z

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