Skip to main content

Advertisement

Log in

Neurological toxicities of targeted therapies in melanoma: a multicenter national observational study of the French Group of Skin Cancers (Groupe de Cancérologie Cutanée, GCC)

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript
  • 1 Altmetric

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Heinzerling L, Eigentler TK, Fluck M et al (2019) Tolerability of BRAF/MEK inhibitor combinations: adverse event evaluation and management. ESMO Open 4(3):e000491. https://doi.org/10.1136/esmoopen-2019-000491

    Article  PubMed  PubMed Central  Google Scholar 

  2. Meirson T, Asher N, Bomze D et al (2020) Safety of BRAF+MEK inhibitor combinations: severe adverse event evaluation. Cancers (Basel) 12(6):E1650. https://doi.org/10.3390/cancers12061650

    Article  CAS  Google Scholar 

  3. Sunandana C, Jacob SC, Jeffrey AS (2023) Melanoma: does sequencing really matter? J Clin Oncol 41(2):167–169. https://doi.org/10.1200/JCO.22.01354

    Article  Google Scholar 

  4. Douglas BJ, Ali M, Alexandra MH et al (2019) Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study. J Immunother Cancer 7(1):134. https://doi.org/10.1186/s40425-019-0617-x

    Article  Google Scholar 

  5. Muhammad ZF, Sheeba BA, Prasanth L (2022) Association of immune checkpoint inhibitors with neurologic adverse events: a systematic review and meta-analysis. JAMA Netw Open 5(4):e227722. https://doi.org/10.1001/jamanetworkopen.2022.7722

    Article  Google Scholar 

  6. Picca A, Birzu C, Berzero G (2022) Peripheral neuropathies after BRAF and/or MEK inhibitor treatment: a pharmacovigilance study. Br J Clin Pharmacol 88(11):4941–4949. https://doi.org/10.1111/bcp.15513

    Article  CAS  PubMed  Google Scholar 

  7. Velter C, Libenciuc C, Routier E et al (2019) Neurotoxicity induced by targeted therapies in patients treated for metastatic melanoma. Eur J Cancer 111:8–11. https://doi.org/10.1016/j.ejca.2019.01.017

    Article  CAS  PubMed  Google Scholar 

  8. Eggermont AMM, Robert C, Ribas A (2018) The new era of adjuvant therapies for melanoma. Nat Rev Clin Oncol 15(9):535–536. https://doi.org/10.1038/s41571-018-0048-5

    Article  CAS  PubMed  Google Scholar 

  9. Luke JJ, Rutkowski P, Queirolo P, Del Vecchio M, Mackiewicz J, Chiarion-Sileni V et al (2022) Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial. Lancet 399(10336):1718–1729. https://doi.org/10.1016/S0140-6736(22)00562-1

    Article  CAS  PubMed  Google Scholar 

  10. Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR et al (2013) BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res 19(5):1225–1231. https://doi.org/10.1158/1078-0432.CCR-12-1630

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CNJ, Sloss CM et al (2010) Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 70(13):5213–5219. https://doi.org/10.1158/0008-5472.CAN-10-0118

    Article  CAS  PubMed  Google Scholar 

  12. Baroffio A, Dupin E, Le Douarin NM (1991) Common precursors for neural and mesectodermal derivatives in the cephalic neural crest. Development 112(1):301–305. https://doi.org/10.1242/dev.112.1.301

    Article  CAS  PubMed  Google Scholar 

  13. Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW, Lloyd AC (2004) The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation. EMBO J 23(15):3061–3071

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This article has no funding source.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Emilie Gérard.

Ethics declarations

Conflicts of interest

The authors have no financial interests in this article. EG: congress fees and investigator for Novartis and Pierre Fabre Dermatology. FD, MBB, APL, VH, MSJ, SA, MTL, AK, and BD have no conflict of interest. CD: congress fees, consulting, boards and investigation on trials for Novartis and Pierre Fabre Oncology. GQ: congress fees, investigator, board member, or consultant for BMS, Regeneron, MSD, Pfizer, Novartis, Pierre Fabre oncology and Sanofi. MA: has received fees from BMS, Pierre Fabre oncology, Sanofi and Sun Pharma for advisory board, financial support for congress participation. FA is board member or consultant or received payment for development of educational presentations and including travel/accommodations expenses covered or reimbursed from Abbvie, Amgen, Almirall, MSD, BMS, Pfizer, Abbott, Janssen-Cilag, Galderma, Leo Pharma, Medac, Galderma, Kiowa Kirin Pharma, UCB, Novartis, Sanofi, Takeda, La Roche Posay, Sun Pharma, Uriage, Viatris. ChN is a consultant or member of advisory boards with BMS, MSD and Novartis and has received financial support for travel and accommodation expenses from BMS, MSD and Novartis. SM: Pierre Fabre et novartis, advisory Board and congress fees. SP: congress fees and investigator for Novartis and Pierre Fabre Dermatology.

Ethical standard statement

This study adheres to the ethical standards outlined in the Declaration of Helsinki. The research protocol was approved by the institutional review board, and all participants provided informed consent. Confidentiality and privacy of the subjects were maintained throughout the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hazard, M., Duval, F., Dutriaux, C. et al. Neurological toxicities of targeted therapies in melanoma: a multicenter national observational study of the French Group of Skin Cancers (Groupe de Cancérologie Cutanée, GCC). J Neurol 271, 1473–1482 (2024). https://doi.org/10.1007/s00415-023-12105-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-023-12105-2

Navigation