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Thrombocytopenia and declines in platelet counts: predictors of mortality and outcome after mechanical thrombectomy

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Abstract

Background and purpose

Acute ischemic stroke (AIS) has well-known risk factors. The role of platelets in patients treated using mechanical thrombectomy (MT) has not been studied. The aim of this study was to study if there is an association of initial thrombocytopenia (TP) and a decline of platelets counts (DPC) with the clinical outcomes, mortality and intracranial hemorrhage (ICH) rates in AIS patients treated with MT.

Materials and methods

In a case–control study consecutive MT-stroke patients were analyzed. A multivariate logistic regression model was used to test for good clinical outcome (mRS 90 days <= 2) and mortality adjusting for age, initial NIHSS, pretreatment with tPA, statins and platelet inhibitors, occlusion site, time from symptom onset to recanalization, initial TP (< 150 × 109/L) and DPC (> 26%). Additionally, rates of ICH were compared.

Results

Of 294 patients included, 9.6% had an initial TP and 23.8% a DPC > 26%. The mortality rate in patients with normal platelet counts was 26.1% vs. 48.3% (p = 0.002) in patients with initial TP with an aOR of 3.47 (CI 1.28–9.4, p = 0.005). No difference regarding the rate of good clinical outcome (p = 0.204) and ICH (p = 0.18) was observed. A DPC of more than 26% during the first 5 days of hospitalization predicted the rate of mortality (aOR 2.4 CI 1.14–5.04, p = 0.021) and the chances of a good clinical outcome (aOR 0.291 CI 0.128–0.666, p = 0.003) without significant differences of ICH rates (p = 0.735).

Conclusion

In AIS patients treated with MT an initial TP was independently associated with higher mortality rates and a marked DPC with higher mortality rates as well as poorer clinical outcomes.

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Author information

Authors and Affiliations

  1. Department of Diagnostic and Interventional Neuroradiology, Klinikum Rechts der Isar, Technical University Munich, Ismaninger Straße 22, 81675, Munich, Germany

    Sebastian Mönch, Tobias Boeckh-Behrens, Kornelia Kreiser, Dennis Hedderich, Christian Maegerlein, Maria Berndt, Manuel Lehm, Claus Zimmer & Benjamin Friedrich

  2. Department of Hematology and Oncology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany

    Philipp Blüm

  3. Department of Neurology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany

    Silke Wunderlich

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  1. Sebastian Mönch
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  2. Tobias Boeckh-Behrens
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  3. Kornelia Kreiser
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  4. Philipp Blüm
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  5. Dennis Hedderich
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  6. Christian Maegerlein
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  7. Maria Berndt
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  10. Claus Zimmer
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  11. Benjamin Friedrich
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Corresponding author

Correspondence to Sebastian Mönch.

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Ethical standards

This study was approved by the local ethics committee of the Technical University Munich. It has, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Written patient consent was waived by the local ethics committee due to the retrospective design.

Conflicts of interest

BF: Consultant for Stryker, speaker honoraria for Medtronic; CM: Consultant for Stryker and Penumbra.

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Mönch, S., Boeckh-Behrens, T., Kreiser, K. et al. Thrombocytopenia and declines in platelet counts: predictors of mortality and outcome after mechanical thrombectomy. J Neurol 266, 1588–1595 (2019). https://doi.org/10.1007/s00415-019-09295-z

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  • DOI: https://doi.org/10.1007/s00415-019-09295-z

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