References
Evans RM, Mangelsdorf DJ (2014) Nuclear receptors, RXR, and the big bang. Cell 157(1):255–266
Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75(4):275–293
Farol LT, Hymes KB (2004) Bexarotene: a clinical review. Expert Rev Anticancer Ther 4(2):180–188
Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE et al (2012) ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335(6075):1503–1506
Fitz NF, Cronican AA, Lefterov I, Koldamova R (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924
Tesseur I, Lo AC, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M et al (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924
Price AR, Xu G, Siemienski ZB, Smithson LA, Borchelt DR, Golde TE et al (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924
Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J et al (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924
Landreth GE, Cramer PE, Lakner MM, Cirrito JR, Wesson DW, Brunden KR et al (2013) Response to comments on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924
Bomben V, Holth J, Reed J, Cramer P, Landreth G, Noebels J (2014) Bexarotene reduces network excitability in models of Alzheimer’s disease and epilepsy. Neurobiol Aging 35(9):2091–2095
Lefterov I, Schug J, Mounier A, Nam KN, Fitz NF, Koldamova R (2015) RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment. Neurobiol Dis 82:132–140
Balducci C, Paladini A, Micotti E, Tolomeo D, La Vitola P, Grigoli E et al (2015) The continuing failure of bexarotene in Alzheimer’s disease mice. J Alzheimers Dis 46(2):471–482
O’Hare E, Jeggo R, Kim EM, Barbour B, Walczak JS, Palmer P et al (2016) Lack of support for bexarotene as a treatment for Alzheimer’s disease. Neuropharmacology 100:124–130
McFarland K, Spalding TA, Hubbard D, Ma JN, Olsson R, Burstein ES (2013) Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson’s disease. ACS Chem Neurosci 4(11):1430–1438
Riancho J, Ruiz-Soto M, Villagrá NT, Berciano J, Berciano MT, Lafarga M (2014) Compensatory motor neuron response to chromatolysis in the murine hSOD1 G93A model of amyotrophic lateral sclerosis. Front Cell Neurosci 8:346
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Riancho, J., Berciano, M.T., Berciano, J. et al. Relaunching an old drug: the potential role of bexarotene in neurodegenerative diseases. J Neurol 263, 177–178 (2016). https://doi.org/10.1007/s00415-015-8004-0
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DOI: https://doi.org/10.1007/s00415-015-8004-0