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Relaunching an old drug: the potential role of bexarotene in neurodegenerative diseases

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References

  1. Evans RM, Mangelsdorf DJ (2014) Nuclear receptors, RXR, and the big bang. Cell 157(1):255–266

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75(4):275–293

    Article  CAS  PubMed  Google Scholar 

  3. Farol LT, Hymes KB (2004) Bexarotene: a clinical review. Expert Rev Anticancer Ther 4(2):180–188

    Article  CAS  PubMed  Google Scholar 

  4. Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE et al (2012) ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335(6075):1503–1506

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Fitz NF, Cronican AA, Lefterov I, Koldamova R (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Tesseur I, Lo AC, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M et al (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924

    Article  CAS  PubMed  Google Scholar 

  7. Price AR, Xu G, Siemienski ZB, Smithson LA, Borchelt DR, Golde TE et al (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924

    Article  CAS  PubMed  Google Scholar 

  8. Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J et al (2013) Comment on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924

    Article  CAS  PubMed  Google Scholar 

  9. Landreth GE, Cramer PE, Lakner MM, Cirrito JR, Wesson DW, Brunden KR et al (2013) Response to comments on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science 340(6135):924

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Bomben V, Holth J, Reed J, Cramer P, Landreth G, Noebels J (2014) Bexarotene reduces network excitability in models of Alzheimer’s disease and epilepsy. Neurobiol Aging 35(9):2091–2095

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Lefterov I, Schug J, Mounier A, Nam KN, Fitz NF, Koldamova R (2015) RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment. Neurobiol Dis 82:132–140

    Article  CAS  PubMed  Google Scholar 

  12. Balducci C, Paladini A, Micotti E, Tolomeo D, La Vitola P, Grigoli E et al (2015) The continuing failure of bexarotene in Alzheimer’s disease mice. J Alzheimers Dis 46(2):471–482

    Article  CAS  PubMed  Google Scholar 

  13. O’Hare E, Jeggo R, Kim EM, Barbour B, Walczak JS, Palmer P et al (2016) Lack of support for bexarotene as a treatment for Alzheimer’s disease. Neuropharmacology 100:124–130

    Article  PubMed  Google Scholar 

  14. McFarland K, Spalding TA, Hubbard D, Ma JN, Olsson R, Burstein ES (2013) Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson’s disease. ACS Chem Neurosci 4(11):1430–1438

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Riancho J, Ruiz-Soto M, Villagrá NT, Berciano J, Berciano MT, Lafarga M (2014) Compensatory motor neuron response to chromatolysis in the murine hSOD1 G93A model of amyotrophic lateral sclerosis. Front Cell Neurosci 8:346

    Article  PubMed Central  PubMed  Google Scholar 

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Correspondence to Javier Riancho.

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Riancho, J., Berciano, M.T., Berciano, J. et al. Relaunching an old drug: the potential role of bexarotene in neurodegenerative diseases. J Neurol 263, 177–178 (2016). https://doi.org/10.1007/s00415-015-8004-0

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  • DOI: https://doi.org/10.1007/s00415-015-8004-0

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