Skip to main content
SpringerLink
Log in

Mitochondrial control region variation in a Korean population sample

  • Population Data
  • Published:
International Journal of Legal Medicine Aims and scope Submit manuscript

Abstract

Mitochondrial DNA (mtDNA) control region (16024-576) sequences were generated from 281 individuals from South Korea. Robotic liquid handling, a redundant sequencing strategy, and a series of quality control checks were implemented to ensure the high quality of the dataset. This population sample showed a low random match probability (0.25 %) and high genetic diversity (0.9933). The haplogroup breakdown was consistent with previous studies describing Korean mtDNA variation. The 224 unique haplotypes (33 shared) presented will supplement the data already publically available.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kim SH, Han MS, Kim W, Kim W (2010) Y chromosome homogeneity in the Korean population. Int J Legal Med 124:653–657

    Article  PubMed  Google Scholar 

  2. Kim SH, Hong SB, Kwak KD, Lee EJ, Kim JJ, Kim KC, Jin HJ, Han MS, Kim W, Kim W (2012) Forensic genetic data of 6 Y-STR loci: an expanded Korean population database. Forensic Sci Int Genet 6:e35–e36

    Article  CAS  PubMed  Google Scholar 

  3. Brandstätter A, Peterson CT, Irwin JA, Mpoke S, Koech DK, Parson W, Parsons TJ (2004) Mitochondrial DNA control region sequences from Nairobi (Kenya): inferring phylogenetic parameters for the establishment of a forensic database. Int J Legal Med 118:294–306

    Article  PubMed  Google Scholar 

  4. Irwin JA, Saunier JL, Strouss KM, Sturk KA, Diegoli TM, Just RS, Coble MD, Parson W, Parsons TJ (2007) Development and expansion of high-quality control region databases to improve forensic mtDNA evidence interpretation. Forensic Sci Int Genet 1:154–157

    Article  PubMed  Google Scholar 

  5. Scheible M, Alenizi M, Sturk-Andreaggi K, Coble MD, Ismael S, Irwin JA (2011) Mitochondrial DNA control region variation in a Kuwaiti population sample. Forensic Sci Int Genet 5:e112–e113

    Article  CAS  PubMed  Google Scholar 

  6. Röck AW, Dur A, van Oven M, Parson W (2013) Concept for estimating mitochondrial DNA haplogroups using a maximum likelihood approach (EMMA). Forensic Sci Int Genet 7:601–609

    Article  PubMed Central  PubMed  Google Scholar 

  7. van Oven M, Kayser M (2009) Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 30:E386–E394

    Article  PubMed  Google Scholar 

  8. Jin HJ, Tyler-Smith C, Kim W (2009) The peopling of Korea revealed by analyses of mitochondrial DNA and Y4chromosomal markers. PLoS One 4:e4210

    Article  PubMed Central  PubMed  Google Scholar 

  9. Lee HY, Yoo JE, Park MJ, Chung U, Shin KJ (2006) Mitochondrial DNA control region sequences in Koreans: identification of useful variable sites and phylogenetic analysis for mtDNA data quality control. Int J Legal Med 120:5–14

    Article  PubMed  Google Scholar 

  10. Kong QP, Yao YG, Liu M, Shen SP, Chen C, Zhu CL, Palanichamy MG, Zhang YP (2003) Mitochondrial DNA sequence polymorphisms of five ethnic populations from northern China. Hum Genet 113:391–405

    Article  CAS  PubMed  Google Scholar 

  11. Parson W, Roewer L (2010) Publication of population data of linearly inherited DNA markers in the International Journal of Legal Medicine. Int J Legal Med 124:505–509

    Article  PubMed  Google Scholar 

  12. Poetsch M, Bajanowski T, Pfeiffer H (2012) The publication of population genetic data in the International Journal of Legal Medicine: guidelines. Int J Legal Med 126:489–490

    Article  Google Scholar 

Download references

Acknowledgments

The authors would like to thank Toni Diegoli, Elizabeth Lyons, Patricia Czarnecki, Jennifer Higginbotham, Kimberly Root, Anastasia Kondakova, Irene Liunoras, Christopher May, Anne Osborn, and Cristina Rentas (AFDIL) for data analysis and review; Walther Parson and Alexander Röck (EMPOP, University of Innsbruck, Austria) for assistance with database confirmation and haplogroup assignments; James Canik, Lanelle Chisolm, Brion Smith, COL Louis Finelli, Lt. Col. Laura Regan, Timothy McMahon, James Ross, Jon Norris, the American Registry of Pathology, and the Armed Forces Medical Examiner System for logistical, administrative, and technical support; and the National Institute of Justice (InterAgency Agreement 2005-DN-R-086) for funding.

The opinions and assertions contained herein are solely those of the authors and are not to be construed as official or as views of the US Department of Defense, its branches, the U.S. Army Medical Research and Materiel Command, the Armed Forces Medical Examiner System, the Federal Bureau of Investigation, the National Institute of Justice, or the U.S. Government.

Author information

Author notes

  1. Michael D. Coble

    Present address: National Institute of Standards and Technology, 100 Bureau Dr., M/S 8312, Gaithersburg, MD, 20899, USA

  2. Jodi A. Irwin

    Present address: Federal Bureau of Investigation Laboratory, 2501 Investigation Parkway, Quantico, VA, 22135, USA

Authors and Affiliations

  1. Armed Forces DNA Identification Laboratory, Armed Forces Medical Examiner System, 115 Purple Heart Drive, Dover, DE, 19902, USA

    Melissa Scheible, Kimberly Sturk-Andreaggi, Michael D. Coble & Jodi A. Irwin

  2. American Registry of Pathology, 120 Old Camden Road, Camden, DE, 19934, USA

    Melissa Scheible, Kimberly Sturk-Andreaggi, Michael D. Coble & Jodi A. Irwin

  3. Eastern District Office, National Forensic Service, Wonju, 220-805, Gangwon Province, Republic of Korea

    Soon Hee Kim

Authors
  1. Melissa Scheible
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Soon Hee Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kimberly Sturk-Andreaggi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael D. Coble
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jodi A. Irwin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kimberly Sturk-Andreaggi.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Table S1

Mitochondrial DNA control region (16024-576) haplotypes and haplogroup assignments in a Korean population sample (n = 281). (XLSX 32 kb)

Table S2

Summary statistics are based on entire control region sequences (16024-576), and insertions at 16193, 309, 315, and 573 were ignored for all calculations. (XLSX 9 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scheible, M., Kim, S.H., Sturk-Andreaggi, K. et al. Mitochondrial control region variation in a Korean population sample. Int J Legal Med 128, 745–746 (2014). https://doi.org/10.1007/s00414-014-0963-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00414-014-0963-7

Keywords

Search

Navigation