Abstract
Idiopathic pulmonary arterial hypertension (IPAH) represents an important clinical indication for lung transplant (LTx) in children. Recent trends show fewer children with IPAH are undergoing LTx nowadays compared to previous time periods, including those with most severe form of the disease. Using the UNOS Registry, we investigated if ECMO at the time of transplant impacts post-transplant survival in children with IPAH. A total of 74 LTx recipients while on ECMO at the time of transplant were identified (IPAH: N = 12). Children with IPAH who underwent LTx while on ECMO had shown comparable survival rates to those who were on ECMO for other conditions. This analysis provides encouraging results, supporting the potential expansion of LTx for this patient population. Given the low number of children undergoing LTx, we think there should be a consensus document to provide better guidance for referring and selecting the high-risk pediatric population with IPAH on ECMO for lung transplant.
References
Hubbard R, Miller R, Tumin D, Tobias JD, Hayes D Jr (2019) Transplant outcomes for idiopathic pulmonary hypertension in children. J Heart Lung Transplant 38(5):580–581
Hayes D Jr, Cherikh WS, Harhay MO, Perch M, Hsich E, Potena L, Sadavarte A, Zehner A, Singh TP, Zuckermann A, Stehlik J (2022) The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-fifth pediatric lung transplantation report—2022; focus on pulmonary vascular diseases. J Heart Lung Transplant 41(10):1348–1356
Ahmed HF, Guzman-Gomez A, Desai M, Dani A, Morales DLS, Critser PJ, Zafar F, Hayes D Jr (2023) Lung transplantation for pulmonary vascular disease in children: a united network for organ sharing analysis. Pediatr Cardiol. https://doi.org/10.1007/s00246-023-03356-x
Koh W, Zang H, Ollberding NJ, Ziady A, Hayes D Jr (2023) Extracorporeal membrane oxygenation bridge to pediatric lung transplantation: modern era analysis. Pediatr Transplant 27(6):e14570
Maxwell BG, Nies MK, Ajuba-Iwuji CC, Coulson JD, Romer LH (2015) Trends in hospitalization for pediatric pulmonary hypertension. Pediatrics 136(2):241–250
Wijeratne DT, Lajkosz K, Brogly SB, Lougheed MD, Jiang L, Housin A, Barber D, Johnson A, Doliszny KM, Archer SL (2018) Increasing incidence and prevalence of World Health Organization Groups 1 to 4 pulmonary hypertension: a population-based cohort study in Ontario, Canada. Circ Cardiovasc Qual Outcomes 11(2):e003973
Acknowledgements
This work was funded by National Institute of Health (NIH 1R01HL147957-01).
Funding
This work was funded by the National Institute of Health: R01HL147957—“Novel Methods to Grow the Impact of Pediatric Thoracic Transplantation”—PI: David L. S. Morales, MD.
Author information
Authors and Affiliations
Contributions
HFA: Conception and design, analysis and interpretation of data, drafting the manuscript. DLSM: Interpretation of data, editing the manuscript. DH: Conception and design, interpretation of data, drafting the manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors report no conflicts of interest and have no relevant disclosures regarding this manuscript.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Ahmed, H.F., Morales, D.L.S. & Hayes, D. ECMO Bridge to Lung Transplant in Children with Idiopathic Pulmonary Arterial Hypertension. Lung (2024). https://doi.org/10.1007/s00408-024-00703-4
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s00408-024-00703-4