Abstract
The aim of the study was to investigate the relationship between slow and forced vital capacity (SVC–FVC) difference with dynamic lung hyperinflation (DH) during the 6-min walking test (6MWT) in subjects with chronic obstructive pulmonary disease (COPD). Twenty-four subjects with COPD (12 males; 67 ± 6 years; forced expiratory volume in first second [FEV1] 56 ± 18% predicted) performed lung function tests by spirometry and plethysmography. DH was assessed by serial measurements of inspiratory capacity (IC) performed during the 6MWT and defined as ∆IC ≥ 150 mL or 10%. IC decrease significantly during the 6MWT (ΔCI: − 0.48 ± − 0.40 L; P < 0.0001), and 18 individuals (75%) presented DH. There was significant difference when comparing IC measured at rest with the other serial IC measurements (P < 0.0001). Correlation between the SVC–FVC difference and DH during the 6MWT was r = − 0.38; P = 0.06. The SVC–FVC difference presented only weak correlation with the development of DH during the 6MWT in patients with COPD.
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The study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq, Brazil.
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Martinez, L., Rodrigues, D., Donária, L. et al. Difference Between Slow and Forced Vital Capacity and Its Relationship with Dynamic Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease. Lung 197, 9–13 (2019). https://doi.org/10.1007/s00408-018-0174-y
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DOI: https://doi.org/10.1007/s00408-018-0174-y