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Risk of Recurrence in Surgically Resected Stage I Adenocarcinoma of the Lung: Histopathologic and Immunohistochemical Analysis

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Abstract

Study Objectives Stage I adenocarcinoma of the lung is the most common type of lung cancer. A better understanding of the histopathology and molecular biology of lung cancer might improve the capability to predict the outcome for any individual patient. The purpose of this study was to evaluate several histopathologic and molecular markers in order to assess their prognostic value in stage I adenocarcinoma. Methods Fifty-five patients at the Seoul National University Bundang Hospital were enrolled in the study. Histopathologic factors and molecular markers were selected. Results Multivariate analysis demonstrated that necrosis, lymphatic vessel invasion, E-cadherin, p53, and Ki-67 emerged as independent prognostic factors of recurrence. When patients were grouped according to low or high risk according to the number of factors involved, the difference in disease-free survival between these groups was statistically significant. Conclusions In resected stage I adenocarcinoma, necrosis, lymphatic vessel invasion, E-cadherin, and p53 have been identified as independent predictors of disease-free survival.

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Acknowledgment

This work was supported by grant No (02-2006-030) from the Seoul National University Bundang Hospital (SNUBH) Research Fund.

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Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, South Korea

    Sukki Cho, Sook-Whan Sung & Sanghoon Jheon

  2. Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, South Korea

    Sook-Whan Sung & Sanghoon Jheon

  3. Department of Pathology, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

    Jin-Haeng Chung

  4. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

    Jin-Haeng Chung

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  1. Sukki Cho
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  2. Sook-Whan Sung
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  4. Jin-Haeng Chung
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Correspondence to Sook-Whan Sung.

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Cho, S., Sung, SW., Jheon, S. et al. Risk of Recurrence in Surgically Resected Stage I Adenocarcinoma of the Lung: Histopathologic and Immunohistochemical Analysis. Lung 186, 411–419 (2008). https://doi.org/10.1007/s00408-008-9116-4

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  • DOI: https://doi.org/10.1007/s00408-008-9116-4

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