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The effectiveness of various treatment approaches for laryngeal contact granulomas

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objectives

To assess and compare the effectiveness of various treatment approaches for laryngeal contact granulomas (LCG).

Methods

A retrospective analysis was conducted on a cohort of 45 patients diagnosed with LCG at the Second Affiliated Hospital of Xi'an Jiaotong University from October 2017 to May 2023. Based on the treatment modalities administered, patients were categorized into three groups: acid suppression alone, hormone injection combined with acid suppression, and surgery combined with acid suppression. Subsequently, the study compared differences in treatment efficacy and average healing time among these three groups, using various indicators.

Results

The findings indicate that the granuloma size in LCG patients with hoarseness (0.126, 95% CI 0.087–0.288) was significantly greater compared to LCG patients without hoarseness (0.047, 95% CI 0.014–0.083) (P = 0.001). However, there were no significant variations in age, morphology (unlobulated/lobulated), laterality ratio (left/right), sex ratio (male/female), history of tracheal intubation (non-intubation/intubation), and RFS score (RFS > 7/RFS ≤ 7) (P > 0.05), regardless of the presence of hoarseness symptoms. At the treatment observation endpoint of 3 months, the curative ratio in the group receiving hormone injection combined with acid suppression was found to be significantly higher compared to the group receiving acid suppression alone (P = 0.018). In addition, the average healing time of patients in the hormone injection combined with acid suppression group was notably shorter than that of the acid suppression alone group (P = 0.007).

Conclusions

The combination of hormonal injections and acid suppression may enhance the curative ratio and expedite the healing time of LCG.

Level of evidence

4.

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Data availability

The data underlying this article will be shared on reasonable request to the corresponding author.

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Funding

This work was supported by the National Natural Science Foundation of China (Program No. 82171129) and the Natural Science Basic Research Program of Shaanxi (Program No.2023-JC-YB-785), the Key Research and Development Projects of Shaanxi (Program No. 2023-YBSF-356).

Author information

Author notes

  1. Yin Qiang and Xiao-Hong Liu have contributed equally to this work.

Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiao Tong University, No.157 Xi-Wu Road, Xi’an, 710004, Shannxi Province, China

    Yin Qiang, Xiao-Hong Liu, Qing-Qing Zhang, Meng Xie, Rui-Xin Guo, Yao Shi, Hao-Nan Yang, Nan Cao & Hua-Nan Luo

Authors
  1. Yin Qiang
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  2. Xiao-Hong Liu
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  3. Qing-Qing Zhang
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  4. Meng Xie
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  5. Rui-Xin Guo
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  6. Yao Shi
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  7. Hao-Nan Yang
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  8. Nan Cao
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  9. Hua-Nan Luo
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Contributions

YQ completed majority of research, participated in conception and design, original draft, conceptualization and data curation. X-HL participated in experiment design, data collection and analysis, writing—original draft. Q-QZ, MX and R-XG collected samples, analyzed data and wrote part of original draft. YS, H-NY and NC participated in experiment design, analysis and interpretation of data, and article revision. The corresponding authors, H-NL, are major contributors in funding acquisition, designed experiments, writing—review and editing.

Corresponding author

Correspondence to Hua-Nan Luo.

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Conflict of interest

All authors have no conflict of interest.

Human rights statement

All the patients have provided written informed consent. The study was performed in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Second Affiliated Hospital of Xi’an Jiaotong University (No. 2022046).

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Qiang, Y., Liu, XH., Zhang, QQ. et al. The effectiveness of various treatment approaches for laryngeal contact granulomas. Eur Arch Otorhinolaryngol 281, 1877–1884 (2024). https://doi.org/10.1007/s00405-023-08436-5

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  • DOI: https://doi.org/10.1007/s00405-023-08436-5

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