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Tumor size rather than the thyroid invasion affects the prognosis of parathyroid carcinoma without lymph node or distant metastasis

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Abstract

Purpose

This study aimed to explore the prognostic value of thyroid invasion of parathyroid carcinoma without lymph node or distant metastasis.

Methods

Two hundred and nine cases of parathyroid carcinoma from the SEER (1989–2014) were eligible for this study. A Chi-squared test, t test, X-tile, Kaplan–Meier curves, and multivariate Cox proportional hazard regression were used for analysis.

Results

Thyroid invasion, sex, race, age, radiation, and surgery were not significantly associated with cancer-specific survival by multivariate analysis. However, tumor size ≥ 4 cm was significantly associated with worse cancer-specific survival (P < 0.001).

Conclusion

Thyroid invasion, which was the criterion for T1 and T2 staging criteria of parathyroid carcinoma according to the AJCC, did not affect the prognosis of patients with parathyroid carcinoma without local lymph node or distant metastasis. Our study indicates that a tumor size ≥ 4 cm may be an appropriate indicator of T1 and T2 cancer staging.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

Funding

The current study was supported by the National Science Foundation of China (Grant nos. 81302368 and 81972896), the Project of State Key Laboratory (State Key Laboratory of oncology in South China, Grant no. HN2019-09) and the Guangdong Province Natural Science Foundation (Grant nos. 2015A030313058 and 2019A1515010288), National Key Clinical Discipline.

Author information

Author notes

  1. Xiao-Mei Sun and Feng Pang contributed equally to this work.

Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, Guangdong, People’s Republic of China

    Xiao-Mei Sun, Feng Pang, Shi-Min Zhuang, Liang-En Xie, Qian-Yi Zhong & Tian-Run Liu

  2. Department of Thyroid Center/Thyroid Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, Guangdong, People’s Republic of China

    Xiao-Mei Sun, Feng Pang, Shi-Min Zhuang, Liang-En Xie, Qian-Yi Zhong & Tian-Run Liu

Authors
  1. Xiao-Mei Sun
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  2. Feng Pang
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  3. Shi-Min Zhuang
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  4. Liang-En Xie
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Contributions

XMS analyzed the data and was a major contributor in writing the manuscript. FP analyzed the data and was a major contributor in writing the manuscript. SMZ checked the data and manuscript. LEX searched the data from SEER and collected it. QYZ analyzed the data. TRL designed the study.

Corresponding author

Correspondence to Tian-Run Liu.

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The authors have indicated that they have no conflicts of interest regarding the content of this article.

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Sun, XM., Pang, F., Zhuang, SM. et al. Tumor size rather than the thyroid invasion affects the prognosis of parathyroid carcinoma without lymph node or distant metastasis. Eur Arch Otorhinolaryngol 279, 4587–4594 (2022). https://doi.org/10.1007/s00405-022-07403-w

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  • DOI: https://doi.org/10.1007/s00405-022-07403-w

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