Skip to main content
SpringerLink
Log in

Red cell distribution width is associated with hearing impairment in chronic kidney disease population: a retrospective cross-sectional study

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Previous studies have shown that inflammatory markers are associated with hearing impairment in participants with inflammatory diseases. Therefore, screening for inflammatory status may have value in predicting the risk of hearing loss (HL) in participants with underlying inflammation. Therefore, red cell distribution width (RDW), an indirect indicator of inflammatory status, was used. The aim of the present study was to evaluate the clinical association between RDW and hearing impairment in a Korean population with chronic kidney disease (CKD).

Methods

In this cross sectional study, a total of 461 participants with estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 were included. Participants were divided into three tertiles based on their RDW values. The threshold values at 0.5, 1, and 2 kHz were averaged to obtain the Low/Mid-Freq, and the values at 3, 4, and 6 kHz were averaged to obtain the High-Freq. The average hearing threshold (AHT) was calculated as the pure-tone average of the thresholds at 0.5, 1, 2, and 3 kHz. HL was defined as an AHT of > 40 dB.

Results

The numbers of participants in the Low, Middle, and High tertiles were 172, 154, and 135, respectively. The AUROCs of RDW and hs-CRP for HL were 0.644 and 0.522, respectively. In the multivariate analysis, the Low/Mid-Freq, High-Freq, and AHT values were lowest in the participants in the Low tertile compared with those in the Middle or High tertiles Multivariate logistic regression analyses showed that participants in the High tertile exhibited 2.32- and 1.78-fold higher odds for HL compared to those of the Low and Middle tertiles, respectively. There were positive associations between RDW and AHT values.

Conclusion

High RDW was associated with increased odds of hearing impairment in the Korean population with CKD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K (2013) Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res 303:30–38

    Article  CAS  Google Scholar 

  2. Oron Y, Elgart K, Marom T, Roth Y (2014) Cardiovascular risk factors as causes for hearing impairment. Audiol Neurootol 19:256–260

    Article  Google Scholar 

  3. Kang SH, Jung DJ, Cho KH, Park JW, Yoon KW, Do JY (2015) The association between metabolic syndrome or chronic kidney disease and hearing thresholds in Koreans: the Korean National Health and Nutrition Examination Survey 2009–2012. PLoS ONE 10:e0120372

    Article  Google Scholar 

  4. Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B et al (2013) Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc 14:877–882

    Article  Google Scholar 

  5. Zhang J, Rane G, Dai X, Shanmugam MK, Arfuso F, Samy RP et al (2016) Ageing and the telomere connection: An intimate relationship with inflammation. Ageing Res Rev 25:55–69

    Article  CAS  Google Scholar 

  6. Bozan N, Alpaycı M, Aslan M, Cankaya H, Kıroglu AF, Turan M et al (2016) Mean platelet volume, red cell distribution width, platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios in patients with ankylosing spondylitis and their relationships with high-frequency hearing thresholds. Eur Arch Otorhinolaryngol 273:3663–3672

    Article  Google Scholar 

  7. Zalawadiya SK, Veeranna V, Panaich SS, Afonso L, Ghali JK (2012) Gender and ethnic differences in red cell distribution width and its association with mortality among low risk healthy United State adults. Am J Cardiol 109:1664–1670

    Article  Google Scholar 

  8. Al-Najjar Y, Goode KM, Zhang J, Cleland JG, Clark AL (2009) Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure. Eur J Heart Fail 11:1155–1162

    Article  CAS  Google Scholar 

  9. Ye Z, Smith C, Kullo IJ (2011) Usefulness of red cell distribution width to predict mortality in patients with peripheral artery disease. Am J Cardiol 107:1241–1245

    Article  Google Scholar 

  10. Ikizler TA (2008) Nutrition, inflammation and chronic kidney disease. Curr Opin Nephrol Hypertens 17:162–167

    Article  CAS  Google Scholar 

  11. Bojakowski K, Dzabic M, Kurzejamska E, Styczynski G, Andziak P, Gaciong Z et al (2012) A high red blood cell distribution width predicts failure of arteriovenous fistula. PLoS ONE 7:e36482

    Article  CAS  Google Scholar 

  12. Yoon HE, Kim SJ, Hwang HS, Chung S, Yang CW, Shin SJ (2015) Progressive rise in red blood cell distribution width predicts mortality and cardiovascular events in end-stage renal disease patients. PLoS ONE 10:e0126272

    Article  Google Scholar 

  13. Gromadziński L, Januszko-Giergielewicz B, Pruszczyk P (2015) Red cell distribution width is an independent factor for left ventricular diastolic dysfunction in patients with chronic kidney disease. Clin Exp Nephrol 19:616–625

    Article  Google Scholar 

  14. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604–612

    Article  Google Scholar 

  15. Peng YF, Zhang Q, Cao L, Liu Y, Chen D, Sun YK et al (2014) Red blood cell distribution width: a potential maker estimating disease activity of ankylosing spondylitis Int J. Clin Exp Med 7:5289–5295

    Google Scholar 

  16. Ulu S, Bucak A, Ulu MS, Ahsen A, Duran A, Yucedag F et al (2014) Neutrophil–lymphocyte ratio as a new predictive and prognostic factor at the hearing loss of diabetic patients. Eur Arch Otorhinolaryngol 271:2681–2686

    Article  Google Scholar 

  17. Balta S, Ozturk C, Kurtoglu E (2014) The neutrophil-lymphocyte ratio is not enough to describe inflammatory condition. Eur Arch Otorhinolaryngol 271:1839–1840

    Article  Google Scholar 

  18. Verschuur CA, Dowell A, Syddall HE, Ntani G, Simmonds SJ, Baylis D et al (2012) Markers of inflammatory status are associated with hearing threshold in older people: findings from the Hertfordshire Ageing Study. Age Ageing 41:92–97

    Article  Google Scholar 

  19. Nash SD, Cruickshanks KJ, Zhan W, Tsai MY, Klein R, Chappell R et al (2014) Long-term assessment of systemic inflammation and the cumulative incidence of age-related hearing impairment in the epidemiology of hearing loss study. J Gerontol A Biol Sci Med Sci 69:207–214

    Article  CAS  Google Scholar 

  20. Sertoglu E, Kayadibi H, Uyanik M (2014) Is single red cell distribution width without iron, folic acid and vitamin B12 enough to decide? Hepatol Res 44:1371

    Article  CAS  Google Scholar 

Download references

Funding

The funding was provided by National Research Foundation of Korea grant funded by the Korea government (Grant No. 2018R1C1B6007775).

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University Hospital, 130, Dongdeok-ro (Samduck-Dong 2ga), Jung-Gu, Daegu, 41944, Republic of Korea

    Da Jung Jung, Myung Hoon Yoo & Kyu-Yup Lee

Authors
  1. Da Jung Jung
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Myung Hoon Yoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyu-Yup Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kyu-Yup Lee.

Ethics declarations

Conflict of interests

The authors declare that they have no conflict of interest to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Kyungpook National University Hospital Institutional Review Board and approval No. KNUH 2019-12-038) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The board waived the need for informed consent, since the subjects’ records and information were anonymized and de-identified prior to the analysis. The study was conducted in accordance with the principles that have their origin in the Declaration of Helsinki.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jung, D.J., Yoo, M.H. & Lee, KY. Red cell distribution width is associated with hearing impairment in chronic kidney disease population: a retrospective cross-sectional study. Eur Arch Otorhinolaryngol 277, 1925–1930 (2020). https://doi.org/10.1007/s00405-020-05912-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-020-05912-0

Keywords

Search

Navigation