Skip to main content

Advertisement

SpringerLink
Log in

Odontogenic tumours: a 25-year epidemiological study in the Marche region of Italy

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Epidemiological data of odontogenic tumours (OT) are conflicting, with significant differences among the countries. This study aims to evaluate incidence and prevalence of OTs in the Marche population in a period of 25 years, according to 4th Edition of WHO Classification.

Methods

In this study, only patients of Marche region treated for OTs were considered. Data were retrieved from Institute of Pathology, Marche Polytechnic University, Italy. Because this is the only tertiary referral centre for Head and Neck pathology within Marche region, the patient sample could be considered well representative of this area. From each case, age, sex, site, diagnosis and relapses were recorded.

Results

Overall, 100 patients were treated for OTs from 1994 to 2018 in Marche region. The annual incidence rate ranged from 0.13 to 0.39 per 100,000, while life prevalence was 6.50 per 100,000. Mean age of onset for primary OTs was 49.7 ± 20.1 years. Twenty-seven patients developed recurrences, showing a mean age of 54 ± 19.7 years and a mean recurrence time of 51.2 ± 34 months.

Conclusion

This is the first epidemiological study on OTs in Italian population according to 4th Edition of WHO Classification. Although limited in their retrospective nature, these findings could accurately estimate epidemiology of OTs in Italy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Rubini C, Mascitti M, Santarelli A, Tempesta A, Limongelli L, Favia G, Maiorano E (2017) Odontogenic tumors: a retrospective clinicopathological study from two Italian centers. Pathologica 109(1):35–46

    CAS  PubMed  Google Scholar 

  2. Barnes L, Eveson JW, Reichart P, Sidransky D (eds) (2005) Pathology and genetics of head and neck tumours. World Health Organization classification of tumours. IARC Press, Lyon

    Google Scholar 

  3. El-Naggar A, Chan J, Rubin Grandis J, Takata T, Slootweg P (eds) (2017) WHO classification of head and neck tumours. World Health Organization classification of tumours, vol 9, 4th edn. International Agency for Research on Cancer, Lyon

    Google Scholar 

  4. Buchner A, Merrell PW, Carpenter WM (2006) Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg 64(9):1343–1352. https://doi.org/10.1016/j.joms.2006.05.019

    Article  PubMed  Google Scholar 

  5. Chapelle KA, Stoelinga PJ, de Wilde PC, Brouns JJ, Voorsmit RA (2004) Rational approach to diagnosis and treatment of ameloblastomas and odontogenic keratocysts. Br J Oral Maxillofac Surg 42(5):381–390. https://doi.org/10.1016/j.bjoms.2004.04.005

    Article  PubMed  Google Scholar 

  6. Lewis CM, Hessel AC, Roberts DB, Guo YZ, Holsinger FC, Ginsberg LE, El-Naggar AK, Weber RS (2010) Prereferral head and neck cancer treatment: compliance with national comprehensive cancer network treatment guidelines. Arch Otolaryngol Head Neck Surg 136(12):1205–1211. https://doi.org/10.1001/archoto.2010.206

    Article  PubMed  PubMed Central  Google Scholar 

  7. Rachanis CC, Shear M (1978) Age-standardized incidence rates of primordial cyst (keratocyst) on the Witwatersrand. Community Dent Oral Epidemiol 6(6):296–299

    Article  CAS  Google Scholar 

  8. Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, Mock D, Nikai H (1998) Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86(6):707–714

    Article  CAS  Google Scholar 

  9. Daley TD, Wysocki GP, Pringle GA (1994) Relative incidence of odontogenic tumors and oral and jaw cysts in a Canadian population. Oral Surg Oral Med Oral Pathol 77(3):276–280

    Article  CAS  Google Scholar 

  10. Arotiba JT, Ogunbiyi JO, Obiechina AE (1997) Odontogenic tumours: a 15-year review from Ibadan, Nigeria. Br J Oral Maxillofac Surg 35(5):363–367

    Article  CAS  Google Scholar 

  11. Adebayo ET, Ajike SO, Adekeye EO (2005) A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg 63(6):811–819. https://doi.org/10.1016/j.joms.2004.03.022

    Article  PubMed  Google Scholar 

  12. Wright JM, Vered M (2017) Update from the 4th Edition of the World Health Organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol 11(1):68–77. https://doi.org/10.1007/s12105-017-0794-1

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kramer IRH, Pindborg JJ, Shear M, Pindborg JJ (1992) Histological typing of odontogenic tumours. International histological classification of tumours, 2nd edn. Springer, Berlin

    Book  Google Scholar 

  14. Lo Muzio L, Santarelli A, Caltabiano R, Rubini C, Pieramici T, Giannone N, Carinci F, Leonardi R, Lanzafame S, Piattelli A (2006) p63 expression correlates with pathological features and biological behaviour of odontogenic tumours. Histopathology 49(2):211–214. https://doi.org/10.1111/j.1365-2559.2006.02423.x

    Article  CAS  PubMed  Google Scholar 

  15. Italian National Institute of Statistics (2019) Resident population on 1st January—Marche region. ISTAT. http://dati.istat.it/?lang=en#. Accessed 19 Feb 2019

  16. Mascitti M, Santarelli A, Zizzi A, Procaccini M, Lo Muzio L, Rubini C (2016) Expression of p73 and TRAIL in odontogenic cysts and tumors. J Oral Sci 58(4):459–464. https://doi.org/10.2334/josnusd.16-0147

    Article  CAS  PubMed  Google Scholar 

  17. Lo Muzio L, Mascitti M, Santarelli A, Rubini C, Bambini F, Procaccini M, Bertossi D, Albanese M, Bondi V, Nocini PF (2017) Cystic lesions of the jaws: a retrospective clinicopathologic study of 2030 cases. Oral Surg Oral Med Oral Pathol Oral Radiol 124(2):128–138. https://doi.org/10.1016/j.oooo.2017.04.006

    Article  PubMed  Google Scholar 

  18. Johnson NR, Savage NW, Kazoullis S, Batstone MD (2013) A prospective epidemiological study for odontogenic and non-odontogenic lesions of the maxilla and mandible in Queensland. Oral Surg Oral Med Oral Pathol Oral Radiol 115(4):515–522. https://doi.org/10.1016/j.oooo.2013.01.016

    Article  PubMed  Google Scholar 

  19. Ochsenius G, Ortega A, Godoy L, Penafiel C, Escobar E (2002) Odontogenic tumors in Chile: a study of 362 cases. J Oral Pathol Med 31(7):415–420

    Article  Google Scholar 

  20. Kebede B, Tare D, Bogale B, Alemseged F (2017) Odontogenic tumors in Ethiopia: eight years retrospective study. BMC Oral Health 17(1):54. https://doi.org/10.1186/s12903-017-0347-8

    Article  PubMed  PubMed Central  Google Scholar 

  21. Chrysomali E, Leventis M, Titsinides S, Kyriakopoulos V, Sklavounou A (2013) Odontogenic tumors. J Craniofac Surg 24(5):1521–1525. https://doi.org/10.1097/SCS.0b013e3182997aaf

    Article  PubMed  Google Scholar 

  22. Taghavi N, Rajabi M, Mehrdad L, Sajjadi S (2013) A 10-year retrospective study on odontogenic tumors in Iran. Indian J Dent Res 24(2):220–224. https://doi.org/10.4103/0970-9290.116688

    Article  PubMed  Google Scholar 

  23. Mosqueda-Taylor A, Ledesma-Montes C, Caballero-Sandoval S, Portilla-Robertson J, Ruiz-Godoy Rivera LM, Meneses-Garcia A (1997) Odontogenic tumors in Mexico: a collaborative retrospective study of 349 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84(6):672–675

    Article  CAS  Google Scholar 

  24. AlSheddi MA, AlSenani MA, AlDosari AW (2015) Odontogenic tumors: analysis of 188 cases from Saudi Arabia. Ann Saudi Med 35(2):146–150. https://doi.org/10.5144/0256-4947.2015.146

    Article  PubMed  PubMed Central  Google Scholar 

  25. Siriwardena BS, Tennakoon TM, Tilakaratne WM (2012) Relative frequency of odontogenic tumors in Sri Lanka: analysis of 1677 cases. Pathol Res Pract 208(4):225–230. https://doi.org/10.1016/j.prp.2012.02.008

    Article  CAS  PubMed  Google Scholar 

  26. Siriwardena B, Crane H, O’Neill N, Abdelkarim R, Brierley DJ, Franklin CD, Farthing PM, Speight PM, Hunter KD (2019) Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016. Oral Surg Oral Med Oral Pathol Oral Radiol 127(2):151–166. https://doi.org/10.1016/j.oooo.2018.09.011

    Article  CAS  PubMed  Google Scholar 

  27. Aregbesola B, Soyele O, Effiom O, Gbotolorun O, Taiwo O, Amole I (2018) Odontogenic tumours in Nigeria: a multicentre study of 582 cases and review of the literature. Med Oral Patol Oral Cir Bucal 23(6):e761–e766. https://doi.org/10.4317/medoral.22473

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Ismail S, Saw CL (2018) A clinicopathologic study of 173 odontogenic tumours in Northern Peninsular Malaysia (2007–2014). Malays J Pathol 40(2):129–135

    CAS  PubMed  Google Scholar 

  29. Naz I, Mahmood MK, Akhtar F, Nagi AH (2014) Clinicopathological evaluation of odontogenic tumours in Pakistan—a seven years retrospective study. Asian Pac J Cancer Prev 15(7):3327–3330

    Article  Google Scholar 

  30. de Medeiros WK, da Silva LP, Santos PP, Pinto LP, de Souza LB (2018) Clinicopathological analysis of odontogenic tumors over 22 years period: experience of a single center in northeastern Brazil. Med Oral Patol Oral Cir Bucal 23(6):e664–e671. https://doi.org/10.4317/medoral.22618

    Article  PubMed  PubMed Central  Google Scholar 

  31. Deepthi PV, Beena VT, Padmakumar SK, Rajeev R, Sivakumar R (2016) A study of 1177 odontogenic lesions in a South Kerala population. J Oral Maxillofac Pathol 20(2):202–207. https://doi.org/10.4103/0973-029X.185897

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Luo HY, Li TJ (2009) Odontogenic tumors: a study of 1309 cases in a Chinese population. Oral Oncol 45(8):706–711. https://doi.org/10.1016/j.oraloncology.2008.11.001

    Article  PubMed  Google Scholar 

  33. Goteti SH (2016) Odontogenic tumors: a review of 675 cases in Eastern Libya. Niger J Surg 22(1):37–40. https://doi.org/10.4103/1117-6806.176397

    Article  PubMed  PubMed Central  Google Scholar 

  34. Tawfik MA, Zyada MM (2010) Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109(2):e67–e73. https://doi.org/10.1016/j.tripleo.2009.09.003

    Article  PubMed  Google Scholar 

  35. Kilinc A, Saruhan N, Gundogdu B, Yalcin E, Ertas U, Urvasizoglu G (2017) Benign tumors and tumor-like lesions of the oral cavity and jaws: an analysis of 709 cases. Niger J Clin Pract 20(11):1448–1454. https://doi.org/10.4103/1119-3077.187309

    Article  CAS  PubMed  Google Scholar 

  36. Worawongvasu R, Tiensuwan M (2015) Odontogenic tumors in Thailand: a study of 590 Thai patients. J Oral Maxillofac Surg Med Pathol 27(4):567–576

    Article  Google Scholar 

  37. Leonardi R, Santarelli A, Barbato E, Ciavarella D, Bolouri S, Harle F, Palazzo G, Lo Muzio L (2010) Atlanto-occipital ligament calcification: a novel sign in nevoid basal cell carcinoma syndrome. Anticancer Res 30(10):4265–4267

    PubMed  Google Scholar 

  38. Avelar RL, Primo BT, Pinheiro-Nogueira CB, Studart-Soares EC, de Oliveira RB, Romulo de Medeiros J, Hernandez PA (2011) Worldwide incidence of odontogenic tumors. J Craniofac Surg 22(6):2118–2123. https://doi.org/10.1097/SCS.0b013e3182323cc7

    Article  PubMed  Google Scholar 

  39. Shear M, Singh S (1978) Age-standardized incidence rates of ameloblastoma and dentigerous cyst on the Witwatersrand, South Africa. Community Dent Oral Epidemiol 6(4):195–199

    Article  CAS  Google Scholar 

  40. Gardner DG (1999) Critique of the 1995 review by Reichart et al. of the biologic profile of 3677 ameloblastomas. Oral Oncol 35(4):443–449

    Article  CAS  Google Scholar 

  41. Simon EN, Merkx MA, Vuhahula E, Ngassapa D, Stoelinga PJ (2005) A 4-year prospective study on epidemiology and clinicopathological presentation of odontogenic tumors in Tanzania. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99(5):598–602. https://doi.org/10.1016/j.tripleo.2004.10.004

    Article  PubMed  Google Scholar 

  42. Larsson A, Almeren H (1978) Ameloblastoma of the jaws. An analysis of a consecutive series of all cases reported to the Swedish Cancer Registry during 1958–1971. Acta Pathol Microbiol Scand A 86A(5):337–349

    CAS  PubMed  Google Scholar 

  43. Chae MP, Smoll NR, Hunter-Smith DJ, Rozen WM (2015) Establishing the natural history and growth rate of ameloblastoma with implications for management: systematic review and meta-analysis. PLoS One 10(2):e0117241. https://doi.org/10.1371/journal.pone.0117241

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. McClary AC, West RB, McClary AC, Pollack JR, Fischbein NJ, Holsinger CF, Sunwoo J, Colevas AD, Sirjani D (2016) Ameloblastoma: a clinical review and trends in management. Eur Arch Otorhinolaryngol 273(7):1649–1661. https://doi.org/10.1007/s00405-015-3631-8

    Article  PubMed  Google Scholar 

  45. Petrelli A, Di Napoli A, Sebastiani G, Giorgi Rossi A, Rossi P, Demuru E, Costa G, Zengarini N, Alicandro G, Marchetti S, Marmot M, Frova L (2019) Italian Atlas of mortality inequalities by education level. Epidemiol Prev 43(1S1):1–120. https://doi.org/10.19191/ep19.1.s1.002

    Article  PubMed  Google Scholar 

Download references

Funding

None declared.

Author information

Authors and Affiliations

  1. Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Via Tronto 10, 60126, Ancona, Italy

    Marco Mascitti, Lucrezia Togni, Antonio Sabatucci & Andrea Santarelli

  2. Department of Clinical and Experimental Medicine, University of Foggia, Via A. Gramsci 89/91, 71122, Foggia, Italy

    Giuseppe Troiano, Vito Carlo Alberto Caponio & Lorenzo Lo Muzio

  3. Department of Oral and Head-Neck Surgery, Umberto I General Hospital, Marche Polytechnic University, Via Conca 71, 60030, Ancona, Italy

    Andrea Balercia

  4. Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Via Tronto 10, 60126, Ancona, Italy

    Corrado Rubini

  5. Dentistry Clinic, National Institute of Health and Science of Aging, INRCA, Via Tronto 10, 60126, Ancona, Italy

    Andrea Santarelli

Authors
  1. Marco Mascitti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lucrezia Togni
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giuseppe Troiano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vito Carlo Alberto Caponio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Antonio Sabatucci
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Andrea Balercia
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Corrado Rubini
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lorenzo Lo Muzio
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Andrea Santarelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization: MM, LLM, AS; methodology: LT, GT, VCAC; formal analysis and investigation: CR, GT, VCAC; writing—original draft preparation: MM, LT, AB; writing—review and editing: AS; supervision: LLM, AS, CR. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Marco Mascitti.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was conducted in accordance with the “Ethical Principles for Medical Research Involving Human Subjects” statement of the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Research involving human participant and animal rights

This study received exemption from the institutional review board, because of its retrospective nature. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary Table

 1: Average yearly population in Marche region for the period 1994–2018, reported by the Italian National Institute of Statistics (ISTAT). (XLSX 20 kb)

Supplementary Table

 2: Annual incidence rate of odontogenic tumours in Marche population (1994–2018). (XLSX 16 kb)

Supplementary Table

 3: Clinical and pathological data of OTs in paediatric patients of Marche population (1994–2018). (DOCX 15 kb)

Supplementary Table

 4: Clinical and pathological data of OTs in geriatric patients of Marche population (1994–2018). (DOCX 16 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mascitti, M., Togni, L., Troiano, G. et al. Odontogenic tumours: a 25-year epidemiological study in the Marche region of Italy. Eur Arch Otorhinolaryngol 277, 527–538 (2020). https://doi.org/10.1007/s00405-019-05683-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-019-05683-3

Keywords

Search

Navigation