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Efficacy of chitosan dressing on endoscopic sinus surgery: a systematic review and meta-analysis

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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Chitosan dressing might be promising to promote the recovery following endoscopic sinus surgery (ESS). However, the results remain controversial. We conducted a systematic review and meta-analysis to explore the influence of chitosan dressing on ESS. PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of chitosan dressing on endoscopic sinus surgery were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcomes were synechia and hemostasis. Meta-analysis was performed using random-effect model. Four RCTs involving 268 patients were included in the meta-analysis. Overall following ESS, compared with control intervention, chitosan dressing significantly reduced synechia (RR = 0.25; 95% CI 0.13–0.49; P < 0.0001) and promoted hemostasis (RR = 1.70; 95% CI 1.37–2.11; P < 0.00001), but showed no impact on granulations (RR = 1.18; 95% CI 0.72–1.95; P = 0.52), mucosal edema (RR = 0.88; 95% CI 0.60–1.29; P = 0.51), crusting (RR = 0.85; 95% CI 0.48–1.53; P = 0.60), and infection (RR = 0.88; 95% CI 0.51–1.52; P = 0.64). Compared to control intervention, chitosan dressing could significantly decrease edema and improve hemostasis, but had no effect on granulations, mucosal edema, crusting and infection.

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Acknowledgements

This study was supported by Shenzhen Municipal Science and Technology Innovation Committee (No.: CXZZ20140509151403304); Health and Family Planning Commission of Shenzhen Municipality (No.: 201401006).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, 518020, China

    Jing-chun Zhou, Wei Zhang, Zhao-yang Ke & Bo Zhang

  2. Department of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen, 518036, China

    Jing-jing Zhang

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  1. Jing-chun Zhou
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  2. Jing-jing Zhang
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Correspondence to Jing-chun Zhou.

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Zhou, Jc., Zhang, Jj., Zhang, W. et al. Efficacy of chitosan dressing on endoscopic sinus surgery: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 274, 3269–3274 (2017). https://doi.org/10.1007/s00405-017-4584-x

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  • DOI: https://doi.org/10.1007/s00405-017-4584-x

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