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Evaluation of an asymmetric anterior glottic web in an excised canine larynx model

  • Laryngology
  • Published:
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Abstract

The main objective of the study is to model asymmetry within anterior glottic webs in excised larynges using sutures and apply aerodynamic and acoustic analyses. Anterior glottic webs (AGW) were modeled in eight excised larynges using sutures secured at the level of the glottis to mimic the scar tissue of the web. Each of the eight larynges were tested under three different pressure increments for each of the three models of AGW: symmetric, vertically asymmetric, and laterally asymmetric. Phonation threshold pressure (PTP) and flow (PTF) differed significantly across AGW conditions (p = 0.006 and p = 0.005, respectively). Additionally, vocal efficiency was significantly different among conditions (p = 0.005) as well as significantly lower in the asymmetric groups (p = 0.015 and p = 0.007). Perturbation measures were not significantly different across conditions. Correlation dimension (D2) was significantly different at PTP, 1.25 × PTP, and 1.5 × PTP (p = 0.003, p = 0.010, and p < 0.001, respectively) as well as significantly higher in the asymmetric groups at each pressure increment. The increased PTP, PTF, and D2 values as well as decreased vocal efficiency among the asymmetric conditions indicates a significant decrease in vocal function, and thus represents that asymmetries could be a contributing factor to the pathological symptoms associated with glottic webs.

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Acknowledgements

This study was supported by NIH from the National Institute of Deafness and other Communication Disorders (Grant No. RO1 DC006019) and NSFC (81329001).

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    Authors and Affiliations

    1. Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53792, USA

      Allyson C. Pulvermacher, Robert Leggon III., Randal Mills & Jack J. Jiang

    2. Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, Throat Hospital of Fudan University, Shanghai, 200031, China

      Chao Xue & Jack J. Jiang

    3. 1300 University Avenue, 2745 Medical Sciences Center, Madison, WI, 53706, USA

      Jack J. Jiang

    Authors
    1. Allyson C. Pulvermacher
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    2. Chao Xue
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    3. Robert Leggon III.
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    4. Randal Mills
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    5. Jack J. Jiang
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    Corresponding author

    Correspondence to Jack J. Jiang.

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    The authors declare that they have no conflict of interest.

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    All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.

    Additional information

    A. C. Pulvermacher and C. Xue have the same contribution in this paper and they are co-first authors.

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    Pulvermacher, A.C., Xue, C., Leggon, R. et al. Evaluation of an asymmetric anterior glottic web in an excised canine larynx model. Eur Arch Otorhinolaryngol 274, 1609–1615 (2017). https://doi.org/10.1007/s00405-016-4364-z

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    • DOI: https://doi.org/10.1007/s00405-016-4364-z

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