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Is there a gender-related susceptibility for cisplatin ototoxicity?

  • Otology
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Abstract

Ototoxicity is a well-known side effect of cisplatin. Some genetic and non-genetic risk factors were described for cisplatin ototoxicity. Although there are some studies which point out a sex-related difference for cisplatin nephrotoxicity and neurotoxicity, sex-related differences for cisplatin ototoxicity have not been studied. The aim of this study is to reveal whether there is any gender-related difference for susceptibility to cisplatin ototoxicity in rats. Fourteen male, 14 female Wistar albino rats were divided into four groups; a female control, a male control, a female cisplatin and a male cisplatin group. Distortion Product Otoacoustic Emission and, Auditory Brainstem Response measurements were obtained. For the cisplatin groups 16 mg/kg of cisplatin was applied. On the 4th day audiological examinations were repeated. After killing, cochleae and brainstem tissues were evaluated by light and electron microscopy. The hearing of the female rat cisplatin group was found to have deteriorated more than the hearing of the male rat cisplatin group. Histopathological evaluation revealed more serious damage in the spiral ganglion and brainstem tissues of female rats. Hearing of female rats deteriorated more than the hearing of male rats upon application of cisplatin. This difference in hearing can be attributed to the more severe damage seen in neuronal tissues such as spiral ganglion cells and brainstem neurons.

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Acknowledgments

This study was financially supported by a grant from Dokuz Eylul University Research Foundation.

Conflict of interest

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Authors and Affiliations

  1. School Of Medicine, Department of Otorhinolaryngology, Dokuz Eylül University, Izmir, Turkey

    Günay Kirkim & Yüksel Olgun

  2. School Of Medicine, Department of Basic Oncology, Dokuz Eylül University, Izmir, Turkey

    Safiye Aktas, Zekiye Altun & Pınar Erçetin

  3. School Of Medicine, Department of Physiology, Dokuz Eylül University, Izmir, Turkey

    Müge Kiray

  4. School Of Medicine, Department of Laboratory Of Animal Science, Dokuz Eylül University, Izmir, Turkey

    Efsun Kolatan & Osman Yilmaz

  5. School Of Medicine, Department of Histology, Dokuz Eylül University, Izmir, Turkey

    Alper Bagriyanik

  6. School Of Medicine, Department of Biostatistics, Dokuz Eylül University, Izmir, Turkey

    Hülya Ellidokuz

Authors
  1. Günay Kirkim
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  2. Yüksel Olgun
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  3. Safiye Aktas
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  4. Müge Kiray
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  5. Efsun Kolatan
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  6. Zekiye Altun
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  7. Pınar Erçetin
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  8. Alper Bagriyanik
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  9. Osman Yilmaz
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  10. Hülya Ellidokuz
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Correspondence to Yüksel Olgun.

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Kirkim, G., Olgun, Y., Aktas, S. et al. Is there a gender-related susceptibility for cisplatin ototoxicity?. Eur Arch Otorhinolaryngol 272, 2755–2763 (2015). https://doi.org/10.1007/s00405-014-3283-0

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  • DOI: https://doi.org/10.1007/s00405-014-3283-0

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