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The association between pregnancies complicated with isolated polyhydramnios or oligohydramnios and offspring long-term gastrointestinal morbidity

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

Infants born to mothers with pregnancies complicated by polyhydramnios or oligohydramnios are at an increased risk for significant adverse perinatal outcome. We sought to assess whether in utero exposure to amniotic fluid abnormalities increases the risk of long-term gastrointestinal (GI) morbidity in the offspring.

Methods

In a population-based cohort study, the incidence of GI-related hospitalizations was compared between singletons exposed and unexposed to oligohydramnios or polyhydramnios. Deliveries occurred between the years 1991–2014 in a regional tertiary medical center. Offspring GI morbidity was assessed up to the age of 18 years according to a pre-defined set of International Classification of Diseases, ninth revision (ICD-9) codes associated with hospitalization. A Kaplan–Meier survival curve was used to compare cumulative morbidity incidence. A Cox proportional hazard model was performed to control for confounders.

Results

During the study period, 186,196 newborns met the inclusion criteria, of which 2.1% (n = 4063) and 3.0% (n = 5684) were born following pregnancies with oligohydramnios and polyhydramnios, respectively. The Kaplan–Meier curve demonstrated that children exposed to isolated oligohydramnios (but not to polyhydramnios) had higher cumulative incidence of GI morbidity (log-rank test, p = 0.001). In the Cox regression model, controlled for maternal age, gestational age, birth weight, and mode of delivery, isolated oligohydramnios (adjusted HR 1.2, 95% CI 1.04–1.34, p = 0.007), but not polyhydramnios (adjusted HR 1.1, 95% CI 0.91–1.13, p = 0.766), was found to be independently associated with long-term GI morbidity of the offspring.

Conclusion

In utero exposure to isolated oligohydramnios is an independent risk factor for long-term GI morbidity in the offspring.

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Funding

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Soroka University Medical Center, POB 151, 84101, Beer-Sheva, Israel

    Aviv Amitai, Eyal Sheiner, Asnat Walfisch & Gali Pariente

  2. Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel

    Tamar Wainstock

  3. Department of Pediatrics, Soroka University Medical Center, 84101, Beer-Sheva, Israel

    Daniella Landau

Authors
  1. Aviv Amitai
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  2. Tamar Wainstock
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  3. Eyal Sheiner
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  4. Asnat Walfisch
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  5. Daniella Landau
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  6. Gali Pariente
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Contributions

AA: manuscript writing. TW: data collection and data analysis. ES: protocol development and manuscript editing. AW: manuscript editing. DL: manuscript editing. GP: manuscript editing

Corresponding author

Correspondence to Eyal Sheiner.

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Conflict of interest

The authors declare that they have no conflicts of interest. The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

Authors approve, and the study was approved by the local ethical committee, according to the declaration of Helsinki (REB number-SOR-0438-15).

Informed consent

This is a retrospective study. The study was approved by the local ethical committee, according to the declaration of Helsinki (REB number-SOR-0438-15).

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Amitai, A., Wainstock, T., Sheiner, E. et al. The association between pregnancies complicated with isolated polyhydramnios or oligohydramnios and offspring long-term gastrointestinal morbidity. Arch Gynecol Obstet 300, 1607–1612 (2019). https://doi.org/10.1007/s00404-019-05330-6

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  • DOI: https://doi.org/10.1007/s00404-019-05330-6

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