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Deleterious impact of maternal hepatitis-C viral infection on maternal and fetal outcome: a 5-year prospective study

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

An Editorial Expression of Concern to this article was published on 17 February 2023

17 February 2023 An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1007/s00404-023-06975-0

This article has been updated

Abstract

Objective

To assess prospectively the maternal and fetal outcome among pregnant women with chronic Hepatitis-C virus (HCV) infection compared to normal control group.

Methods

A prospective observational study conducted on 342 pregnant women with HCV who were divided into two groups according to polymerase chain reaction (PCR) result, group 1 (n = 184, HCV-PCR negative) and group 2 (n = 154, HCV-PCR positive) with a third group of normal pregnant women (n = 170). Obstetric outcome was recorded.

Results

Patients with positive HCV-PCR have more elevated liver enzymes (p < 0.05) and lower prothrombin INR (p < 0.001) than those with negative HCV-PCR testing. Fewer patients with HCV received previous medical treatment (16/342, 4.6%). More women in the HCV groups delivered by vacuum or cesarean section (p < 0.05), experienced higher rates of antepartum hemorrhage, postpartum hemorrhage, anemia, development of GDM, premature rupture of membranes, repeated hospital admissions, blood transfusions, admission to ICU and maternal mortality (p < 0.001) compared to the control group. Fetuses of women with HCV infections were more prone to IUFD with higher rates of low birth weight, prematurity, low Apgar scores at 5 min, admission to NICU, need for ventilation, and acquisition of HCV (p < 0.001) as well as neonatal mortality (p < 0.05) compared to the control group.

Conclusion

Patients with HCV infection even those without viremia suffered poor maternal and fetal outcome. Multidisciplinary management of the affected patients should be implemented to improve their obstetric outcome.

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Change history

  • 16 December 2022

    Editors Note: Readers are alerted that the reliability of data presented in this article is currently in question. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.

  • 17 February 2023

    An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1007/s00404-023-06975-0

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Acknowledgements

The authors would like to acknowledge the contribution of the residents and nursing staff of the outpatient clinics of the National liver institute and delivery ward of Menoufia university Hospital.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, 25 Yasin Abdelghafar Street, Shibin El-kom, Menoufia Governorate, Egypt

    Mohamed Rezk

  2. Department of Pediatrics, Faculty of Medicine, Menoufia University, 25 Yasin Abdelghafar Street, Shibin El-kom, Menoufia Governorate, Egypt

    Zein Omar

Authors
  1. Mohamed Rezk
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  2. Zein Omar
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Contributions

MR: Project development, Data Collection and Manuscript writing. ZO: Project development and Data collection.

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Correspondence to Mohamed Rezk.

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Conflict of interest

Declare that no conflicts of interest in relation to this article exist.

Ethical approval

All procedures performed in the current study involving human participants were in accordance with the ethical standards of the Menoufia Faculty of Medicine research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Rezk, M., Omar, Z. Deleterious impact of maternal hepatitis-C viral infection on maternal and fetal outcome: a 5-year prospective study. Arch Gynecol Obstet 296, 1097–1102 (2017). https://doi.org/10.1007/s00404-017-4550-2

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  • DOI: https://doi.org/10.1007/s00404-017-4550-2

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