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Maternal Serum S100-B, PAPP-A and IL-6 levels in severe preeclampsia

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Aim

We aimed to investigate the relationship of maternal serum levels of S100-B, PAPP-A and IL-6 with severe preeclampsia.

Materials and methods

This prospective case–control study consisted of 27 severe preeclamptic and 36 healthy singleton pregnancies. The groups were matched for parity, maternal age and body mass index. Maternal blood sampling for S100B, PAPP-A and IL-6 was performed at the morning after an overnight fasting.

Results

S100-B concentrations were significantly higher in severe preeclampsia group (0.09 ± 0.05 vs. 0.13 ± 0.01 µg/L; p = 0.025). PAPP-A levels were higher (196.54 ± 21.56 vs. 208.80 ± 23.97 mIU/ml; p = 0.707) and IL-6 levels were lower in severe preeclamptic group (68.79 ± 29.89 vs. 37.30 ± 6.46 pg/ml; p = 0.372). AUC value for S100-B was calculated as 0.712. When cutoff level for serum S100-B for predicting severe preeclampsia was regarded as 0.0975 µg/L, sensitivity and specificity were found to be 81.4 % and 58.3 %, respectively. Pregnancies with ≥0.0975 µg/L S100-B levels had 12.75-fold increased risk for having CNS symptoms (OR 12.75; 95 % CI 2.69–60.28) and 3.27-fold increased risk for having HELLP syndrome (OR 3.27; 95 % CI 0.62–17.36).

Conclusion

Our results suggest that serum S100B levels may be a potential marker in severe preeclampsia for the severity of hypoperfusion both in placenta and brain pointing at subsequent risk of organ failure.

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References

  1. Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM (2011) Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag 7:467–474

    PubMed Central  PubMed  Google Scholar 

  2. Deen ME, Ruurda LG, Wang J, Dekker GA (2006) Risk factors for preeclampsia in multiparous women: primipaternity versus the birth interval hypothesis. J Matern Fetal Neonatal Med. 19(2):79–84

    Article  PubMed  Google Scholar 

  3. Al-Jameila N, Khana FA, Khana MF, Tabassuma HT (2014) A Brief overview of preeclampsia. J Clin Med Res. 6(1):1–7

    Article  Google Scholar 

  4. Spencer K, Cowans NJ, Nicholaides KH (2008) Low levels of maternal serum PAPP-A in the first trimester and the risk of preeclampsia. Prenat Diagn 28:7–10

    Article  PubMed  Google Scholar 

  5. Donato R (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33:637–668

    Article  CAS  PubMed  Google Scholar 

  6. Schmidt AP, Tort ABL, Amaral OB et al (2004) Serum S100B in pregnancy-related hypertensive disorders: a case-control study. Clin Chem 50(2):435–438

    Article  CAS  PubMed  Google Scholar 

  7. Petzold A, Green AJ, Keir G et al (2002) Role of Serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study. Crit Care Med 30:2705–2710

    Article  CAS  PubMed  Google Scholar 

  8. Farina A, Rapacchia G, Sterrantino FA, Pula G et al (2011) Prospective Evaluation of ultrasound and biochemical-based multivariable models for the prediction of late pre-eclampsia. Prenat Diagn 12:1147–1152

    Google Scholar 

  9. Montanari L, Alfei A, Albonico G et al (2009) The impact of first-trimester serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A on the diagnosis of fetal growth restriction and small for gestational age infant. Fetal Diagn Ther 1:130–135

    Article  Google Scholar 

  10. Smith GC, Stenhouse EJ, Crossley JA et al (2002) Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab 4:1762–1767

    Article  Google Scholar 

  11. Dugoff L, Hobbins JC, Malone FD et al (2004) First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial). Am J Obstet Gynecol 4:1446–1451

    Article  Google Scholar 

  12. Lovati E, Beneventi F, Simonetta M, Laneri M et al (2013) Gestational diabetes mellitus: including serum pregnancy-associated plasma protein-A testing in the clinical management of primiparous women? A case–control study. Diabetes Res Clin Pract 100(3):340–347

    Article  CAS  PubMed  Google Scholar 

  13. Marchi N, Angelov L, Masaryk T et al (2007) Seizure-promoting effect of blood–brain barrier disruption. Epilepsia. 48(4):732–742. doi:10.1111/j.1528-1167.2007.00988.x

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Scott WK, Wang Y, Scott WW (1995) Preeclampsia is associated with decreased placental IL-6 production. Repr Sci. 2(4):614–617. doi:10.1177/107155769500200406

    Google Scholar 

  15. Tosun M, Celik H, Avci B et al (2010) Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med. 23(8):880–886. doi:10.3109/14767051003774942

    Article  CAS  PubMed  Google Scholar 

  16. Guven MA, Coskun A, Ertas IE et al (2009) Association of maternal serum CRP, IL-6, TNF-α Homocysteine, Folic Acid and Vitamin B12 levels with the severity of preeclampsia and fetal birth weight. Hypertens Pregnancy 28(2):190–200. doi:10.1080/10641950802601179

    Article  CAS  PubMed  Google Scholar 

  17. Borekci B, Aksoy H, Al RA et al (2007) Maternal serum interleukin-10, interleukin-2 and interleukin-6 in pre-eclampsia and eclampsia. Am J Reprod Immunol 58(1):56–64

    Article  CAS  PubMed  Google Scholar 

  18. Hayashi M, Ueda Y, Ohkura T et al (2005) IL-6 concentrations in the placenta and blood in normal pregnancies and preeclampsia. Horm Metab Res 37(7):419–424. doi:10.1055/s-2005-870231

    Article  CAS  PubMed  Google Scholar 

  19. Hypertension in Pregnancy (Report of the ACOG Task Force on Hypertension in Pregnancy) (2013). Obstetrics and Gynecology, Vol. 122, No. 5

  20. PTskitishvilli E, Sharentuya N, Temma-Asona K, Mimura K, Kinugasa-Taniguchi Y, Kanagawa T, et al. (2010). Oxidative stress-induced S100B protein from placenta and amnion affects soluble endoglin release from endothelial cells. Mol Hum Reprod 16:188–199

  21. Vettorazzi J, Torres FV, Avila TT, Martins-Costa SH, et al. (2012). Serum S100B in pregnancy complicated by preeclampsia: a case control study. Pregn Hypertens (2):101–105

  22. Atis A, Aydin Y, Basol E, Kaleli S, Turgay F, Goker N (2012) PAPP-A levels of late pregnancy in preeclampsia and HELLP Syndrome. Arch Gynecol Obstet 285:45–49

    Article  CAS  PubMed  Google Scholar 

  23. Elisavet S, Anastasios S, Eleanna G, Stelios K, Constantinos G, Christina P (2013) Serum s100B protein is increased and correlates with interleukin 6, hypoperfusion indices, and outcome in patients admitted for surgical control of hemorrhage. Shock. 40(4):274–280

    Article  Google Scholar 

  24. Steiner J, Schiltz K, Walter M, Wunderlich MT, Keilhoff G, Brisch R et al (2010) S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research. Psychoneuroendocrinology. 35(2):321–324

    Article  CAS  PubMed  Google Scholar 

  25. Tskitishvili E, Komoto Y, Kinugasa Y, Kanagawa T, Song M, Mimura K et al (2007) Level of S100B protein expression in the amnion at various gestational ages in the third trimester of normal pregnancies. Acta Obstet Gynecol Scand 86(8):915–920

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Celal Bayar University, Manisa, Turkey

    Burcu Artunc-Ulkumen & Asli Goker

  2. Department of Biochemistry, Celal Bayar University, Manisa, Turkey

    Yesim Guvenc & Ceyhun Gozukara

Authors
  1. Burcu Artunc-Ulkumen
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  2. Yesim Guvenc
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  3. Asli Goker
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  4. Ceyhun Gozukara
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Correspondence to Burcu Artunc-Ulkumen.

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Artunc-Ulkumen, B., Guvenc, Y., Goker, A. et al. Maternal Serum S100-B, PAPP-A and IL-6 levels in severe preeclampsia. Arch Gynecol Obstet 292, 97–102 (2015). https://doi.org/10.1007/s00404-014-3610-0

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  • DOI: https://doi.org/10.1007/s00404-014-3610-0

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