Abstract
Purpose
We investigate sex differences in the incidence of stillbirth, neonatal mortality, and perinatal mortality among singletons born to mothers with preeclampsia or eclampsia.
Methods
Retrospective cohort analysis of a population-based sample of singleton births covering the period 1989 through 2005 (n = 56,313).
Results
The study population comprised 26,931 female (47.8%) and 29,382 male infants (52.2%; referent group). Overall, the prevalence of stillbirth, neonatal mortality and perinatal mortality were 0.68, 0.52 and 1.2%, respectively. There was no sex difference in the incidence of stillbirth, neonatal or perinatal mortality among offspring of mothers in this study.
Conclusion
Although there was a preponderance of male infants among mothers with preeclampsia or eclampsia, we did not observe any sex-associated differences in fetal or neonatal survival among offspring of mothers with preeclampsia or eclampsia.
References
Sheiner E, Levy A, Katz M, Hershkovitz R, Leron E, Mazor M (2004) Gender does matter in perinatal medicine. Fetal Diagn Ther 19:366–369
Naeye RL, Burt LS, Wright DL, Blanc WA, Tatter D (1971) Neonatal mortality, the male disadvantage. Pediatrics 48:902–906
Sheiner E, Levy A, Feinstein U, Hallak M, Mazor M (2002) Risk factors and outcome of failure to progress during the first stage of labor: a population-based study. Acta Obstet Gynecol Scand 81:222–226
Feinstein U, Sheiner E, Levy A, Hallak M, Mazor M (2002) Risk factors for arrest of descent during the second stage of labor. Int J Gynaecol Obstet 77:7–14
Hershkovitz R, Silberstein T, Sheiner E, Shoham-Vardi I, Holcberg G, Katz M, Mazor M (2001) Risk factors associated with true knots of the umbilical cord. Eur J Obstet Gynecol Reprod Biol 98:36–39
Blickstein I, Shoham-Schwartz Z, Lancet M (1987) Predisposing factors in the formation of true knots of the umbilical cord—analysis of morphometric and perinatal data. Int J Gynaecol Obstet 25:395–398
Dawes NW, Dawes GS, Moulden M, Redman CW (1999) Fetal heart rate patterns in term labor vary with sex, gestational age, epidural analgesia, and fetal weight. Am J Obstet Gynecol 180:181–187
Sheiner E, Hadar A, Hallak M, Katz M, Mazor M, Shoham-Vardi I (2001) Clinical significance of fetal heart rate tracings during the second stage of labor. Obstet Gynecol 97:747–752
Eogan MA, Geary MP, O’Connell MP, Keane DP (2003) Effect of fetal sex on labour and delivery: retrospective review. BMJ 326:137
McGregor JA, Leff M, Orleans M, Baron A (1992) Fetal gender differences in preterm birth: findings in a North American cohort. Am J Perinatol 9:43–48
Ingemarsson I (2003) Gender aspects of preterm birth. BJOG 110(Suppl 20):34–38
Vatten LJ, Skjaerven R (2004) Offspring sex and pregnancy outcome by length of gestation. Early Hum Dev 76:47–54
Bekedam DJ, Engelsbel S, Mol BW, Buitendijk SE, e Bruin KM (2002) Male predominance in fetal distress during labor. Am J Obstet Gynecol 187:1605–1607
Ghidini A, Salafia CM (2005) Gender differences of placental dysfunction in severe prematurity. BJOG 112:140–144
Naeye RL, Demers LM (1987) Differing effects of fetal sex on pregnancy and its outcome. Am J Med Genet Suppl 3:67–74
Martin J, Curtin S, Saulnier M, Mousavi J (2003) Development of the matched multiple birth file. 1995–1998 matched multiple birth dataset. NCHS CD-ROM series 21, no. 13a. National Center for Health Statistics, Hyattsville
Hernández-Díaz S, Toh S, Cnattingius S (2009) Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ 338:b2255
Kesmodel U, Wisborg K, Olsen SF, Henriksen TB, Secher NJ (2002) Moderate alcohol intake during pregnancy and the risk of stillbirth and death in the first year of life. Am J Epidemiol 155:305–312
Alexander GR, Cornely DA (1987) Prenatal care utilization: its measurement and relationship to pregnancy outcome. Am J Prev Med 3:243–253
Clayton D, Hills M (1993) Statistical models in epidemiology. Oxford University Press, Oxford
Zetterström K, Lindeberg SN, Haglund B, Hanson U (2008) The association of maternal chronic hypertension with perinatal death in male and female offspring: a record linkage study of 866,188 women. BJOG 115:1436–1442
Campbell DM, MacGillivray I, Carr-Hill R, Samphier M (1983) Fetal sex and pre-eclampsia in primigravidae. Br J Obstet Gynaecol 90:26–27
Clifton VL (2010) Review: sex and the human placenta: mediating differential strategies of fetal growth and survival. Placenta 24:S33–S39
James WH (1995) Sex ratios of offspring and the causes of placental pathology. Hum Reprod 10:1403–1406
Stark MJ, Clifton VL, Wright IM (2009) Neonates born to mothers with preeclampsia exhibit sex-specific alterations in microvascular function. Pediatr Res 65:292–295
Mbah AK, Alio AP, Marty PJ, Bruder K, Whiteman VE, Salihu HM (2010) Pre-eclampsia in the first pregnancy and subsequent risk of stillbirth in black and white gravidas. Eur J Obstet Gynecol Reprod Biol 149:165–169
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Aliyu, M.H., Salihu, H.M., Lynch, O. et al. Fetal sex and differential survival in preeclampsia and eclampsia. Arch Gynecol Obstet 285, 361–365 (2012). https://doi.org/10.1007/s00404-011-1984-9
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DOI: https://doi.org/10.1007/s00404-011-1984-9