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Clinical outcomes and survival rate of autologous chondrocyte implantation with and without concomitant meniscus allograft transplantation: 10- to 15-year follow-up study

  • Arthroscopy and Sports Medicine
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was to compare the clinical outcomes and survival rate of autologous chondrocyte implantation (ACI) with or without concomitant meniscus allograft transplantation (MAT).

Methods

Patients who underwent ACI of the medial or lateral femoral condyle with or without concomitant MAT were retrospectively reviewed. There were 14 patients (mean age, 31.2 ± 9.9 years) who underwent isolated ACI and 19 patients who underwent ACI with concomitant MAT (mean age, 34.8 ± 8.4 years). The International Knee Documentation Committee (IKDC) subjective score, Lysholm score, Tegner activity score, and 10- to 15-year survival rate were compared between groups.

Results

All clinical scores showed significant improvement postoperatively in both groups. At final follow-up, the IKDC subjective score was superior in isolated ACI (75.8 ± 18.4) compared to ACI with MAT (61.0 ± 16.6, p = 0.024). The Lysholm score was also higher in isolated ACI (77.5 ± 19.1) than ACI with MAT (62.5 ± 18.1, p = 0.029). The Tegner activity score did not differ between treatments (isolated ACI, 5.3 ± 1.1; ACI with MAT, 4.5 ± 1.3; p = 0.072). The 15-year survival rate for isolated ACI was higher than that of ACI with concomitant MAT (69.6% vs 50.2%), but this difference was not statistically significant (p = 0.19).

Conclusions

ACI with concomitant MAT did not restore clinical outcomes as much as isolated ACI. There was a trend for the long-term survival rate to be greater in isolated ACI than ACI with MAT. These results should be considered in planning for the treatment of focal chondral defect with meniscus deficiency.

Level of study

Retrospective comparative trial; level of evidence, 3.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kyung Hee University Hospital, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea

    Kyoung Ho Yoon, Se Gu Kang, Yoo Beom Kwon, Eung Ju Kim & Sang-Gyun Kim

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  1. Kyoung Ho Yoon
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  2. Se Gu Kang
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  3. Yoo Beom Kwon
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  4. Eung Ju Kim
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  5. Sang-Gyun Kim
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Correspondence to Sang-Gyun Kim.

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Institutional review board approval was obtained by the ethics committee of Kyung Hee University Hospital (IRB Number: KHUH 2018-04-042).

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Yoon, K.H., Kang, S.G., Kwon, Y.B. et al. Clinical outcomes and survival rate of autologous chondrocyte implantation with and without concomitant meniscus allograft transplantation: 10- to 15-year follow-up study. Arch Orthop Trauma Surg 139, 1117–1123 (2019). https://doi.org/10.1007/s00402-019-03148-0

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  • DOI: https://doi.org/10.1007/s00402-019-03148-0

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