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How to: Antiarrhythmika in der klinischen Anwendung

How to: clinical use of antiarrhythmic drugs

  • #AbMorgenRhythmologie
  • Published:
Herzschrittmachertherapie + Elektrophysiologie Aims and scope Submit manuscript

Zusammenfassung

In der Therapie von Herzrhythmusstörungen spielen Antiarrhythmika als nichtinvasive Therapieoption zur Rhythmuskontrolle eine wichtige Rolle. In Abhängigkeit von der Wirkung auf unterschiedliche Ionenkanäle werden die Medikamente in unterschiedliche Gruppen unterteilt – der gezielte Einsatz variiert je nach Art der Herzrhythmusstörung. Wissen über den Wirkmechanismus trägt zum besseren Verständnis für den jeweiligen Einsatz des Antiarrhythmikums bei. Diese Übersichtsarbeit fasst Wirkweise, Indikationen, Kontraindikationen und Nebenwirkungen unterschiedlicher Wirkstoffe zusammen und unterstützt somit die adäquate Anwendung der einzelnen Antiarrhythmika im klinischen Alltag.

Abstract

Antiarrhythmic drugs are important for the noninvasive rhythm control therapy of heart rhythm disorders. Antiarrhythmic drugs, which can be categorized into subgroups based on their different effects on ion channels, are clinically used for various types of arrhythmias. Knowledge about these specific electrophysiological effects contributes to a better understanding in order to select the correct drug for each specific arrhythmia. This review summarizes mechanisms, indications, contraindications, and side effects of the different antiarrhythmic drugs and, thus, supports their adequate use in daily clinical routine.

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Authors and Affiliations

  1. Hannover Herzrhythmus Centrum, Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland

    Henrike A. K. Hillmann &  David Duncker

  2. Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Niederlande

    Konstanze Betz & Dominik Linz

  3. Klinik für Innere Medizin, Kardiologie, Eifelklinik St. Brigida GmbH & Co. KG, Simmerath, Deutschland

    Konstanze Betz

  4. Department of Cardiology, Radboud University Medical Center and Radboud Institute for Health Science, Nijmegen, Niederlande

    Dominik Linz

  5. Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australien

    Dominik Linz

  6. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Kopenhagen, Dänemark

    Dominik Linz

Authors
  1. Henrike A. K. Hillmann
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  2. Konstanze Betz
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  3. Dominik Linz
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  4. David Duncker
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Correspondence to David Duncker.

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Interessenkonflikt

H.A.K. Hillmann und K. Betz geben an, dass kein Interessenkonflikt besteht. Die Universität Maastricht und Universität Copenhagen erhielten für Vortrags‑, Consulting- und Forschungs-Aktivitäten von D. Linz finanzielle Unterstützung von Bayer, Biosense Webster, Astra Zeneca, Biotronik, Medtronic, Microport, NovoNordisk. D. Duncker received modest lecture honorary, travel grants and/or a fellowship grant from Abbott, Astra Zeneca, Biotronik, Boehringer Ingelheim, Boston Scientific, Bristol Myers Squibb, CVRx, Medtronic, Microport, Pfizer, Zoll.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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D. Duncker, Hannover

V. Johnson, Gießen

Die Autorinnen Henrike A. K. Hillmann und Konstanze Betz haben zu gleichen Teilen zum Manuskript beigetragen.

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Hillmann, H.A.K., Betz, K., Linz, D. et al. How to: Antiarrhythmika in der klinischen Anwendung. Herzschr Elektrophys 34, 82–90 (2023). https://doi.org/10.1007/s00399-022-00919-y

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  • DOI: https://doi.org/10.1007/s00399-022-00919-y

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