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Morphology control of magnetic latex particles prepared from oil in water ferrofluid emulsion

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Abstract

The use of magnetic latex particles as solid support in biomedical applications is favourable when homogeneous and well-defined core–shell polymer particles are used. Accordingly, this paper concerns with the synthesis of magnetic poly(styrene–divinylbenzene) latex particles using emulsion polymerization of styrene (St) and divinylbenzene (DVB) monomers in the presence of preformed oil in water organic ferrofluid emulsion droplets as seed. The key parameters which affect on formation and morphology of the prepared magnetic latexes were investigated, including type of magnetic emulsion, St/DVB monomers ratio, DVB amount, type of initiator and surfactant nature. In this study, two different magnetic emulsions were used, low and high octane content magnetic emulsions. The magnetic emulsions were stabilized using different types of surfactants including AP, Triton X 405 and SDS. In addition, four different initiators, including AIBN, V50, ACPA and KPS were examined. The morphology of the prepared magnetic latexes was investigated using transmission electron microscopy. In addition, particle size and size distribution, magnetic content and magnetic properties of the prepared magnetic latexes were also examined, using various techniques, e.g. dynamic light scattering, thermal gravimetric analysis and vibrating sample magnetometer, respectively. The results showed that the morphology type (Janus like, moon like and/or core–shell) of the prepared magnetic latex particles could be controlled depending mainly on the used formulation. In fact, the use of styrene monomer leads to anisotropic morphology. Whereas, the progressive use of DVB in presence of KPS intiator leads to a well-defined magnetic core and polymer shell structure.

 

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References

  1. Rahman MM, Elaissari A (2011) Organic-inorganic hybrid magnetic latex. In: van Herk AM, Landfester K (eds) Preparation with (mini)emulsion polymerization, vol 233, Advances in Polymer Science Series. Springer-Verlag, Berlin, p 237–281

    Google Scholar 

  2. Ugelstad J, Stenstad P, Kilaas L, Prestvik WS, Herje R, Berge A, Hornes E (1993) Monodispersed magnetic polymer particles. Blood Purif 11:349–369

    Article  CAS  Google Scholar 

  3. Niemeyer CM (2001) Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science. Angew Chem Int Ed 40:4128–4158

    Article  CAS  Google Scholar 

  4. Elaissari A, Veyret R, Mandrand B, Chatterjee J (2004) Biomedical application for magnetic latexes. In: Elaissari A (ed) Colloidal biomolecules, biomaterials, and biomedical applications, vol 116. Marcel Dekker, New York, pp 1–26

    Google Scholar 

  5. Norde W (1997) Interaction of proteins with polymeric and other colloids. In: Asua JM (ed) Polymeric dispersions: principles and applications, vol 335, NATO ASI Series. Kluwer Academic Publishers, London, pp 541–555

    Chapter  Google Scholar 

  6. Pichot C, Delair T, Elaissari A (1997) Polymer colloids for biomedical and pharmaceutical applications. In: Asua JM (ed) Polymeric dispersions: principles and applications, vol 335, NATO ASI series. Kluwer, Dordrecht, pp 515–539

    Google Scholar 

  7. Elaissari A, Fessi H (2010) Reactive and highly submicron magnetic latexes for bionanotechnology applications. Macromol Symp 288:115–120

    Article  CAS  Google Scholar 

  8. Solc J (1982) A colloidal size hydrophobic polymer particulate having discrete particles of an inorganic material dispersed therein. Patent EP 0054832

  9. Lee J, Senna M (1995) Preparation of monodispersed polystyrene microspheres uniformly coated by magnetite via heterogeneous polymerization. Colloid Polym Sci 273:76–82

    Article  CAS  Google Scholar 

  10. Yanase N, Noguchi H, Asakura H, Suzuta T (1993) Preparation of magnetic latex particles by emulsion polymerization of styrene in the presence of a ferrofluid. J Appl Polym Sci 50:765–776

    Article  CAS  Google Scholar 

  11. Richard J, Vaslin S (199p) Latex of calibrated monodisperse magnetizable microspheres, process of preparation and use of the said latex in chemistry or in biology. US Patent 5,976,426

  12. Daniel J-C, Schuppiser JL, Tricot M (1981) Magnetic polymer latex and preparation process. US Patent 4358388

  13. Charmot D, Vidil C (1990) Magnetizable composite microspheres of hydrophobic crosslinked polymer, preparation process of same and application in biology. Patent EP 0390634 B1

  14. Ugelstad J, Ellingsen T, Berge A, Helgee B (1986) Process for the production of magnetic polymer particles. Patent EP 0106873

  15. Furusawa K, Nagashima K, Anzai C (1994) Synthetic process to control the total size and component distribution of multilayer magnetic composite particles. Colloid Polym Sci 272:1104–1110

    Article  CAS  Google Scholar 

  16. Elaissari A, Pichot C, Mandrand B, Sauzedde F (1997) Superparamagnetic monodispersed particles. Patent WO 9745202

  17. Caruso F, Susha AS, Giersig M, Möhwald H (1999) Magnetic core-shell particles: preparation of magnetite multilayers on polymer latex microspheres. Adv Mater 11(11):950–953

    Article  CAS  Google Scholar 

  18. Wormuth K (2001) Superparamagnetic latex via inverse emulsion polymerization. J Colloid Interf Sci 241:366–377

    Article  CAS  Google Scholar 

  19. Ramirez LP, Landfester K (2003) Magnetic polystyrene nanoparticles with high magnetic content obtained by miniemulsion process. Macromol Chem Phys 204:22–31

    Article  CAS  Google Scholar 

  20. Ménager C, Sandre O, Mangili J, Cabuil V (2004) Preparation and swelling of hydrophilic magnetic microgels. Polymer 45:2475–2481

    Article  Google Scholar 

  21. Zheng W, Gao F, Gu H (2005) Magnetic polymer nanospheres with high and uniform magnetite content. J Magn Magn Mater 288:403–410

    Article  CAS  Google Scholar 

  22. Zheng W, Gao F, Gu H (2005) Carboxylated magnetic polymer latexes: preparation, characterization and biomedical applications. J Magn Magn Mater 293:199–205

    Article  CAS  Google Scholar 

  23. Vestal CR, Zhang ZJ (2002) Atom transfer radical polymerization synthesis and magnetic characterization of MnFe2O4/polystyrene core/shell nanoparticles. J Am Chem Soc 124:14312–14313

    Article  CAS  Google Scholar 

  24. Matsuno R, Yamamoto K, Otsuka H, Takahara A (2003) Polystyrene-grafted magnetite nanoparticles prepared through surface-initiated nitroxide-mediated radical polymerization. Chem Mater 15:3–5

    Article  CAS  Google Scholar 

  25. Matsuno R, Yamamoto K, Otsuka H, Takahara A (2004) Polystyrene and poly(3-vinylpyridine)-grafted magnetite nanoparticles prepared through surface-initiated nitroxide-mediated radical polymerization. Macromoleclues 37:2203–2209

    Article  CAS  Google Scholar 

  26. Montagne F, Mondain-Monval O, Pichot C, Elaissari A (2006) Highly magnetic latexes from submicrometer oil in water ferrofluid emulsion. J Polym Sci Pol Chem 44(8):2642–2656

    Article  CAS  Google Scholar 

  27. Montagne F, Braconnot S, Mondain-Monval O, Pichot C, Elaissari A (2003) Colloidal and physicochemical characterization of highly magnetic O/W magnetic emulsion. J Disp Sci Tech 24(6):821–832

    Article  CAS  Google Scholar 

  28. Rahman MM, Montagne F, Fessi H, Elaissari A (2011) Anisotropic magnetic microparticles from ferrofluid emulsion. Soft Matter 7:1483–1490

    Article  CAS  Google Scholar 

  29. Xu Y, Xu H, Gu H (2010) Controllable preparation of epoxy-functionalized magnetic polymer latexes with different morphologies by modified miniemulsion polymerization. J Polymer Sci Polymer Chem 48:2284–2293

    CAS  Google Scholar 

  30. Braconnot S, Hoang C, Fessi H, Elaissari A (2009) Elaboration of perfect core-shell submicronic magnetic latexes from oil in water ferrofluid droplets for bionanotechnology applications. Mater Sci Eng C 29:624–630

    Article  CAS  Google Scholar 

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Author notes

  1. M. M. Eissa

    Present address: Polymers Department, National Research Centre, Dokki, Giza, 12622, Egypt

Authors and Affiliations

  1. University of Lyon, F- 69622, Lyon, France

    S. Braconnot, M. M. Eissa & A. Elaissari

  2. University of Lyon-1, Villeurbanne, CNRS, UMR 5007, LAGEP-CPE-308G, 43 bd. du 11 Nov.1918, F- 69622, Villeurbanne, France

    S. Braconnot, M. M. Eissa & A. Elaissari

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  1. S. Braconnot
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Correspondence to A. Elaissari.

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Braconnot, S., Eissa, M.M. & Elaissari, A. Morphology control of magnetic latex particles prepared from oil in water ferrofluid emulsion. Colloid Polym Sci 291, 193–203 (2013). https://doi.org/10.1007/s00396-012-2700-4

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  • DOI: https://doi.org/10.1007/s00396-012-2700-4

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