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Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: an updated meta-analysis

Assoziationen zwischen Interleukin-23R-Polymorphismen und Empfänglichkeit für ankylosierende Spondylitis: eine aktualisierte Metaanalyse

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Abstract

Objective

The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms are associated with susceptibility to ankylosing spondylitis (AS).

Methods

Meta-analyses were conducted to determine the associations between IL-23R polymorphisms and AS susceptibility in Europeans, Asians, and all subjects combined.

Results

A total of 17 studies (21 separate comparisons) were included in this meta-analysis. The meta-analysis revealed a significant association between AS and the two alleles of the rs11209032 polymorphism in all study subjects (odds ratio [OR] = 1.160, 95% confidence interval [CI] = 1.091–1.204, P < 0.001). Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.234, 95% CI = 1.159–1.313, P < 0.001), but not in Asians (OR = 1.003, 95% CI = 0.920–1.219, P = 0.942). Meta-analyses of the rs1004819, rs10489629, rs1343151, rs1495965, rs7517847, and rs11465804 polymorphisms showed the same pattern as shown for rs11209032. The meta-analysis also revealed a significant association between the two alleles of the rs2201841 and rs11209026 polymorphisms and the risk of developing AS in Europeans, but not in Asians. Interestingly, the rs10889677 polymorphism was not found to be associated with AS susceptibility in either Europeans or Asians.

Conclusions

This meta-analysis showed that several IL-23R polymorphisms are associated with the development of AS in Europeans.

Zusammenfassung

Ziel

Ziel der vorliegenden Studie war zu untersuchen, ob Interleukin-23R(IL-23R)-Polymorphismen mit der Empfänglichkeit für eine ankylosierende Spondylitis (AS) assoziiert sind.

Methoden

Es wurden Metaanalysen ausgeführt, um die Assoziationen zwischen IL-23R-Polymorphismen und AS-Empfänglichkeit bei Europäern, Asiaten und allen Teilnehmern zusammen zu ermitteln.

Ergebnisse

Insgesamt wurden 17 Studien (21 separate Vergleiche) in diese Metaanalyse eingeschlossen. Die Metaanalyse ergab eine signifikante Assoziation zwischen AS und den beiden Allelen des rs11209032-Polymorphismus bei allen Studienteilnehmern (Odds Ratio, OR = 1,160; 95 %-Konfidenzintervall, 95 %-KCI = 1,091–1,204; p < 0,001). Die Stratifizierung nach Ethnizität ergab eine signifikante Assoziation zwischen diesem Polymorphismus und AS bei Europäern (OR = 1,234; 95 %-KI = 1,159–1,313; p < 0,001), nicht aber bei Asiaten (OR = 1,003; 95 %-KI = 0,920–1,219; p = 0,942). Metaanalysen der Polymorphismen rs1004819, rs10489629, rs1343151, rs1495965, rs7517847 und rs11465804 wiesen das gleiche Muster auf, das für rs11209032 gezeigt wurde. Die Metaanalyse ergab auch eine signifikante Assoziation zwischen den beiden Allelen des rs2201841-und rs11209026-Polymorphismus und dem Risiko der Entstehung einer AS bei Europäern, nicht aber bei Asiaten. Interessant war, dass der rs10889677-Polymorphismus sich nicht als mit der Empfänglichkeit für AS assoziiert herausstellte, weder bei Europäern noch bei Asiaten.

Schlussfolgerung

Die vorliegende Metaanalyse zeigte, dass verschiedene IL-23R-Polymorphismen mit der Entstehung der AS bei Europäern assoziiert sind.

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Acknowledgements

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Rheumatology, Korea University Medical Center, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, 02841, Seoul, Korea (Republic of)

    Y. H. Lee MD, PhD & G. G. Song

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  1. Y. H. Lee MD, PhD
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  2. G. G. Song
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Correspondence to Y. H. Lee MD, PhD.

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Y. H. Lee and G. G. Song declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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U. Müller-Ladner, Bad Nauheim

U. Lange, Bad Nauheim

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Lee, Y.H., Song, G.G. Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: an updated meta-analysis. Z Rheumatol 78, 272–280 (2019). https://doi.org/10.1007/s00393-018-0472-z

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  • DOI: https://doi.org/10.1007/s00393-018-0472-z

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