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Hypoxie als ein Schlüsselfaktor im Entzündungsgebiet bei rheumatischen Erkrankungen

Hypoxia is a key factor in the inflammatory milieu of rheumatic diseases

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Zusammenfassung

Chronisch-entzündliche Erkrankungen sind charakterisiert durch das Auftreten von Sauerstoffmangel (Hypoxie) und die dadurch bedingte/notwendige zelluläre Adaptation über den hypoxieinduzierbaren Faktor (HIF). Die Modulation dieser Adaptationsmechanismen bildet die Basis für Ideen zur Wirkungsverbesserung bekannter Medikamente und für die Entwicklung neuer therapeutischer Ansatzpunkte.

Abstract

Chronic inflammatory diseases are characterized by hypoxia and subsequent cellular adaptation via hypoxia-inducible factor (HIF). Modulation of these adaptation mechanisms provides the basis for ideas on how to improve the effects of known drugs and for the development of novel therapeutic approaches.

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Authors and Affiliations

  1. Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland

    M. Hahne, T. Gaber & F. Buttgereit

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  1. M. Hahne
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  2. T. Gaber
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  3. F. Buttgereit
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Correspondence to M. Hahne.

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Hahne, M., Gaber, T. & Buttgereit, F. Hypoxie als ein Schlüsselfaktor im Entzündungsgebiet bei rheumatischen Erkrankungen. Z. Rheumatol. 71, 64–67 (2012). https://doi.org/10.1007/s00393-011-0782-x

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