Abstract
Background
Patients with frequent premature ventricular contractions (PVCs) are often highly symptomatic with significantly reduced quality-of-life. We evaluated the outcome and success of PVC ablation in patients in the German Ablation Registry.
Methods
The German Ablation Registry is a nationwide prospective multicenter database of patients who underwent an ablation procedure, initiated by the “Stiftung Institut für Herzinfarktforschung” (IHF), Ludwigshafen, Germany. Data were acquired from March 2007 to May 2011. Patients underwent PVC ablation in the enrolling ablation centers.
Results
A total of 408 patients (age 53.5 ± 15 years, 55 % female) undergoing ablation for PVCs were included. 32 % of patients showed a co-existing structural heart disease. Acute ablation success of the procedure was 82 % in the overall patient group. In patients without structural heart disease, acute success was significantly higher compared with patients with structural heart disease (86 vs. 74 %, p = 0.002). All patients were discharged alive after a median of 3 days. No patient suffered an acute myocardial infarction, stroke, or major bleeding. After 12 months’ follow-up, 99 % of patients were still alive showing a significant different mortality between patients with structural heart disease compared with those without (2.3 vs. 0 %, p = 0.012). In addition, 76 % of patients showed significantly improved symptoms after 12 months of follow-up.
Conclusion
Based on the data from this registry, ablation of PVCs is a safe and efficient procedure with an excellent outcome and improved symptoms after 12 months.
Similar content being viewed by others
References
Dukes JW, Dewland TA, Vittinghoff E et al (2015) Ventricular ectopy as a predictor of heart failure and death. J Am Coll Cardiol 66:101–109. doi:10.1016/j.jacc.2015.04.062
Penela D, Taxis CV, Aguinaga L et al (2013) Neurohormonal, structural, and functional recovery pattern after premature ventricular complex ablation is independent of structural heart disease status in patients with depressed left ventricular ejection fraction: a prospective multicenter study. J Am Coll Cardiol 62:1195–1202. doi:10.1016/j.jacc.2013.06.012
Yokokawa M, Good E, Crawford T et al (2013) Recovery from left ventricular dysfunction after ablation of frequent premature ventricular complexes. Heart Rhythm 10:172–175. doi:10.1016/j.hrthm.2012.10.011
Bogun F, Crawford T, Reich S et al (2007) Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention. Heart Rhythm 4:863–867. doi:10.1016/j.hrthm.2007.03.003
Ling Z, Liu Z, Su L et al (2014) Radiofrequency ablation versus antiarrhythmic medication for treatment of ventricular premature beats from the right ventricular outflow tract: prospective randomized study. Circ Arrhythmia Electrophysiol 7:237–243. doi:10.1161/CIRCEP.113.000805
Zhong L, Lee YH, Huang XM et al (2014) Relative efficacy of catheter ablation vs antiarrhythmic drugs in treating premature ventricular contractions: a single-center retrospective study. Heart Rhythm 11:187–193. doi:10.1016/j.hrthm.2013.10.033
Aliot EM, Stevenson WG, Almendral-Garrote JM et al (2009) EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); i. Heart Rhythm 6:886–933. doi:10.1016/j.hrthm.2009.04.030
Chun KR, Schmidt B, Kuck KH et al (2013) Catheter ablation of atrial fibrillation in the young: insights from the German Ablation Registry. Clin Res Cardiol 102:459–468. doi:10.1007/s00392-013-0553-6
Latchamsetty R, Yokokawa M, Morady F et al (2015) Multicenter outcomes for catheter ablation of idiopathic premature ventricular complexes. JACCCEP 1:116–123. doi:10.1016/j.jacep.2015.04.005
Zang M, Zhang T, Mao J et al (2014) Beneficial effects of catheter ablation of frequent premature ventricular complexes on left ventricular function. Heart 100:787–793. doi:10.1136/heartjnl-2013-305175
Kamioka M, Mathew S, Lin T et al (2015) Electrophysiological and electrocardiographic predictors of ventricular arrhythmias originating from the left ventricular outflow tract within and below the coronary sinus cusps. Clin Res Cardiol 104:544–554. doi:10.1007/s00392-015-0817-4
Baser K, Bas HD, Yokokawa M et al (2014) Infrequent intraprocedural premature ventricular complexes: implications for ablation outcome. J Cardiovasc Electrophysiol 25:1088–1092. doi:10.1111/jce.12454
Pytkowski M, Maciag A, Jankowska A et al (2012) Quality of life improvement after radiofrequency catheter ablation of outflow tract ventricular arrhythmias in patients with structurally normal heart. Acta Cardiol 67:153–159
Echt DS, Liebson PR, Mitchell LB et al (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. doi:10.1056/NEJM199103213241201
Priori SG, BlomstroLundqvist C, Mazzanti A, Bloma N, Borggrefe M, Camm J et al (2015) 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. doi:10.1093/europace/eul108
Author information
Authors and Affiliations
Consortia
Corresponding author
Ethics declarations
Conflict of interest
No conflict of interest for all authors.
Rights and permissions
About this article
Cite this article
Fichtner, S., Senges, J., Hochadel, M. et al. Safety and efficacy in ablation of premature ventricular contraction: data from the German ablation registry. Clin Res Cardiol 106, 49–57 (2017). https://doi.org/10.1007/s00392-016-1022-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00392-016-1022-9