Abstract
Purpose
The effect of different types of lipid emulsion may guide therapy of patients with intestinal failure (IF) to limit morbidity such as intestinal failure-associated liver disease (IFALD).
Methods
A retrospective chart review of pediatric patients with IF who received soybean oil lipid emulsion (SL) or mixed oil lipid emulsion (ML) was performed. Data over 1 year were collected.
Results
Forty-five patients received SL and 34 received ML. There were no differences in the incidence (82 versus 74%, P = 0.35) or resolution (86 versus 92%, P = 0.5) of IFALD between the cohorts. The median dose of ML was higher compared to SL (2 versus 1 g/kg/day, P < 0.001). If resolved, IFALD resolved rapidly in the ML cohort compared to the SL cohort (67 versus 37 days, P = 0.01). Weight gain was higher in the ML compared to the SL cohort at resolution of IFALD or 1 year from diagnosis of IF (P = 0.009).
Conclusion
The administration of ML did not alter the incidence or resolution of IFALD compared to SL in pediatric IF. There was rapid resolution of IFALD and enhanced weight gain in the ML cohort compared to SL in pediatric IF.
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Data availability
All data supporting the findings of this study are available within the paper.
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Acknowledgements
Tina Findley, DO, reviewed the manuscript and provided support through the Summer Research Program at UTHealth McGovern Medical School.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Alexandria Lawrence, Mamta Naik, and Dalya Ferguson. The first draft of the manuscript was written by Alexandria Lawrence and Mamta Naik and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Naik, M., Lawrence, A., Davidson, A. et al. Comparison of two formulations of intravenous lipid emulsions in pediatric intestinal failure. Pediatr Surg Int 40, 97 (2024). https://doi.org/10.1007/s00383-024-05674-4
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DOI: https://doi.org/10.1007/s00383-024-05674-4