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Outcomes in infants with prenatally diagnosed gastroschisis and planned preterm delivery

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Abstract

Background

The timing and mode of delivery of pregnancies with prenatally diagnosed gastroschisis remains controversial.

Aim

To evaluate the outcome of patients with gastroschisis managed during two time periods: 2006–2009 and 2010–2014, with planned elective cesarean delivery at 37 versus 35 gestational weeks (gw). A secondary aim was to analyze the outcome in relation to the gestational age at birth.

Material and methods

Retrospective review of all cases with gastroschisis managed at our institution between 2006 and 2014.

Results

Fifty-two patients were identified, 24 during the initial period, and 28 during the second. There were a significantly higher number of emergency cesarean deliveries in the first period. There were no differences between groups with regard to the use of preformed silo, need of parenteral nutrition or length of hospital stay. When analyzing the outcome in relation to the gw the patients actually were born, we observed that patients delivered between 35 and 36.9 gw were primary closed in 88.5 % of cases, with shorter time on mechanical ventilation, parenteral nutrition and hospital stay.

Conclusion

Planned caesarian section at 35 completed gestational weeks for fetuses with prenatally diagnosed gastroschisis is safe. We observe the best outcome for patients born between 35 and 36.9 gw.

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References

  1. Laughon M, Meyer R, Bose C, Wall A, Otero E, Heerens A, Clark R (2003) Rising birth prevalence of gastroschisis. J Perinatol 23(4):291–293. doi:10.1038/sj.jp.7210896

    Article  PubMed  Google Scholar 

  2. Loane M, Dolk H, Bradbury I, Group EW (2007) Increasing prevalence of gastroschisis in Europe 1980–2002: a phenomenon restricted to younger mothers? Paediatr Perinat Epidemiol 21(4):363–369. doi:10.1111/j.1365-3016.2007.00820.x

    Article  Google Scholar 

  3. Kilby MD (2006) The incidence of gastroschisis. BMJ 332(7536):250–251. doi:10.1136/bmj.332.7536.250

    Article  PubMed Central  PubMed  Google Scholar 

  4. Srinathan SK, Langer JC, Blennerhassett MG, Harrison MR, Pelletier GJ, Lagunoff D (1995) Etiology of intestinal damage in gastroschisis. III: morphometric analysis of the smooth muscle and submucosa. J Pediatr Surg 30(3):379–383

    Article  CAS  PubMed  Google Scholar 

  5. Langer JC, Bell JG, Castillo RO, Crombleholme TM, Longaker MT, Duncan BW, Bradley SM, Finkbeiner WE, Verrier ED, Harrison MR (1990) Etiology of intestinal damage in gastroschisis, II. Timing and reversibility of histological changes, mucosal function, and contractility. J Pediatr Surg 25(11):1122–1126

    Article  CAS  PubMed  Google Scholar 

  6. Langer JC, Longaker MT, Crombleholme TM, Bond SJ, Finkbeiner WE, Rudolph CA, Verrier ED, Harrison MR (1989) Etiology of intestinal damage in gastroschisis. I: effects of amniotic fluid exposure and bowel constriction in a fetal lamb model. J Pediatr Surg 24(10):992–997

    Article  CAS  PubMed  Google Scholar 

  7. Kassa AM, Lilja HE (2011) Predictors of postnatal outcome in neonates with gastroschisis. J Pediatr Surg 46(11):2108–2114. doi:10.1016/j.jpedsurg.2011.07.012

    Article  PubMed  Google Scholar 

  8. Kronfli R, Bradnock TJ, Sabharwal A (2010) Intestinal atresia in association with gastroschisis: a 26-year review. Pediatr Surg Int 26(9):891–894. doi:10.1007/s00383-010-2676-4

    Article  PubMed  Google Scholar 

  9. Molik KA, Gingalewski CA, West KW, Rescorla FJ, Scherer LR, Engum SA, Grosfeld JL (2001) Gastroschisis: a plea for risk categorization. J Pediatr Surg 36(1):51–55. doi:10.1053/jpsu.2001.20004

    Article  CAS  PubMed  Google Scholar 

  10. Tower C, Ong SS, Ewer AK, Khan K, Kilby MD (2009) Prognosis in isolated gastroschisis with bowel dilatation: a systematic review. Arch Dis Child Fetal Neonatal Ed 94(4):F268–F274. doi:10.1136/adc.2008.140434

    Article  CAS  PubMed  Google Scholar 

  11. Skarsgard ED, Claydon J, Bouchard S, Kim PC, Lee SK, Laberge JM, McMillan D, von Dadelszen P, Yanchar N, Canadian Pediatric Surgical N (2008) Canadian pediatric surgical network: a population-based pediatric surgery network and database for analyzing surgical birth defects. The first 100 cases of gastroschisis. J Pediatr Surg 43(1):30–34. doi:10.1016/j.jpedsurg.2007.09.011 (discussion 34)

  12. Ajayi FA, Carroll PD, Shellhaas C, Foy P, Corbitt R, Osawe O, Caniano DA, O’Shaughnessy R (2011) Ultrasound prediction of growth abnormalities in fetuses with gastroschisis. J Matern Fetal Neonatal Med 24(3):489–492. doi:10.3109/14767058.2010.500428

    Article  PubMed  Google Scholar 

  13. Badillo AT, Hedrick HL, Wilson RD, Danzer E, Bebbington MW, Johnson MP, Liechty KW, Flake AW, Adzick NS (2008) Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes. J Pediatr Surg 43(4):647–653. doi:10.1016/j.jpedsurg.2007.09.016

    Article  PubMed  Google Scholar 

  14. Grant NH, Dorling J, Thornton JG (2013) Elective preterm birth for fetal gastroschisis. Cochrane Database Syst Rev 6:CD009394. doi:10.1002/14651858.CD009394.pub2

  15. Abdel-Latif ME, Bolisetty S, Abeywardana S, Lui K (2008) Mode of delivery and neonatal survival of infants with gastroschisis in Australia and New Zealand. J Pediatr Surg 43(9):1685–1690. doi:10.1016/j.jpedsurg.2008.03.053

    Article  PubMed  Google Scholar 

  16. Anteby EY, Yagel S (2003) Route of delivery of fetuses with structural anomalies. Eur J Obstet Gynecol Reprod Biol 106(1):5–9

    Article  PubMed  Google Scholar 

  17. Baird R, Eeson G, Safavi A, Puligandla P, Laberge JM, Skarsgard ED (2011) Institutional practice and outcome variation in the management of congenital diaphragmatic hernia and gastroschisis in Canada: a report from the Canadian Pediatric Surgery Network. J Pediatr Surg 46(5):801–807. doi:10.1016/j.jpedsurg.2011.02.008

    Article  PubMed  Google Scholar 

  18. Bugg GJ, Bisoonddatt R, Stanley EM, Callan S, Bullen PJ (2006) Caesarean section rates in pregnancies complicated by gastroschisis in a tertiary referral centre over a 5-year period (1997–2002). Eur J Obstet Gynecol Reprod Biol 126(2):272–273. doi:10.1016/j.ejogrb.2005.11.037

    Article  CAS  PubMed  Google Scholar 

  19. Case AP, Colpitts LR, Langlois PH, Scheuerle AE (2012) Prenatal diagnosis and cesarean section in a large, population-based birth defects registry. J Matern Fetal Neonatal Med 25(4):395–402. doi:10.3109/14767058.2011.580801

    Article  CAS  PubMed  Google Scholar 

  20. Gelas T, Gorduza D, Devonec S, Gaucherand P, Downham E, Claris O, Dubois R (2008) Scheduled preterm delivery for gastroschisis improves postoperative outcome. Pediatr Surg Int 24(9):1023–1029. doi:10.1007/s00383-008-2204-y

    Article  PubMed  Google Scholar 

  21. Gomez Alcala AV (2004) The “routine” use of cesarean section (CS) for delivery of infants with gastroschisis (Gs) is not warranted. Journal of pediatric surgery 39(12):1885 (author reply 1886)

  22. Hadidi A, Subotic U, Goeppl M, Waag KL (2008) Early elective cesarean delivery before 36 weeks vs late spontaneous delivery in infants with gastroschisis. J Pediatr Surg 43(7):1342–1346. doi:10.1016/j.jpedsurg.2007.12.050

    Article  PubMed  Google Scholar 

  23. Logghe HL, Mason GC, Thornton JG, Stringer MD (2005) A randomized controlled trial of elective preterm delivery of fetuses with gastroschisis. J Pediatr Surg 40(11):1726–1731. doi:10.1016/j.jpedsurg.2005.07.047

    Article  PubMed  Google Scholar 

  24. Maramreddy H, Fisher J, Slim M, Lagamma EF, Parvez B (2009) Delivery of gastroschisis patients before 37 weeks of gestation is associated with increased morbidities. J Pediatr Surg 44(7):1360–1366. doi:10.1016/j.jpedsurg.2009.02.006

    Article  PubMed  Google Scholar 

  25. Puligandla PS, Janvier A, Flageole H, Bouchard S, Laberge JM (2004) Routine cesarean delivery does not improve the outcome of infants with gastroschisis. J Pediatr Surg 39(5):742–745

    Article  PubMed  Google Scholar 

  26. Reigstad I, Reigstad H, Kiserud T, Berstad T (2011) Preterm elective caesarean section and early enteral feeding in gastroschisis. Acta paediatrica (Oslo, Norway: 1992) 100(1):71–74. doi:10.1111/j.1651-2227.2010.01944.x

  27. Glasmeyer P, Grande C, Margarit J, Marti M, Torino JR, Mirada A, Sans A (2012) Gastroschisis. Preterm elective cesarean and immediate primary closure: our experience. Cirugia pediatrica: organo oficial de la Sociedad Espanola de. Cir Pediatr 25(1):12–15

    CAS  PubMed  Google Scholar 

  28. How HY, Harris BJ, Pietrantoni M, Evans JC, Dutton S, Khoury J, Siddiqi TA (2000) Is vaginal delivery preferable to elective cesarean delivery in fetuses with a known ventral wall defect? Am J Obstet Gynecol 182(6):1527–1534. doi:10.1067/mob.2000.106852

    Article  CAS  PubMed  Google Scholar 

  29. Baud D, Lausman A, Alfaraj MA, Seaward G, Kingdom J, Windrim R, Langer JC, Kelly EN, Ryan G (2013) Expectant management compared with elective delivery at 37 weeks for gastroschisis. Obstet Gynecol 121(5):990–998. doi:10.1097/AOG.0b013e31828ec299

    Article  PubMed  Google Scholar 

  30. Salihu HM, Emusu D, Aliyu ZY, Pierre-Louis BJ, Druschel CM, Kirby RS (2004) Mode of delivery and neonatal survival of infants with isolated gastroschisis. Obstet Gynecol 104(4):678–683. doi:10.1097/01.aog.0000139513.93115.81

    Article  PubMed  Google Scholar 

  31. Nasr A, Wayne C, Bass J, Ryan G, Langer JC (2013) Effect of delivery approach on outcomes in fetuses with gastroschisis. J Pediatr Surg 48(11):2251–2255. doi:10.1016/j.jpedsurg.2013.07.004

    Article  PubMed  Google Scholar 

  32. Soares H, Silva A, Rocha G, Pissarra S, Correia-Pinto J, Guimaraes H (2010) Gastroschisis: preterm or term delivery? Clinics (Sao Paulo, Brazil) 65(2):139–142. doi:10.1590/s1807-59322010000200004

  33. Serra A, Fitze G, Kamin G, Dinger J, Konig IR, Roesner D (2008) Preliminary report on elective preterm delivery at 34 weeks and primary abdominal closure for the management of gastroschisis. Eur J Pediatric Surg 18(1):32–37. doi:10.1055/s-2007-965744

  34. Quirk JG Jr., Fortney J, Collins HB, 2nd, West J, Hassad SJ, Wagner C (1996) Outcomes of newborns with gastroschisis: the effects of mode of delivery, site of delivery, and interval from birth to surgery. Am J Obstet Gynecol 174(4):1134–1138 (discussion 1138–1140)

  35. Nasr A, Langer JC (2012) Influence of location of delivery on outcome in neonates with gastroschisis. J Pediatr Surg 47(11):2022–2025. doi:10.1016/j.jpedsurg.2012.07.037

    Article  PubMed  Google Scholar 

  36. Segel SY, Marder SJ, Parry S, Macones GA (2001) Fetal abdominal wall defects and mode of delivery: a systematic review. Obstet Gynecol 98(5 Pt 1):867–873

    Article  CAS  PubMed  Google Scholar 

  37. Moore TC, Collins DL, Catanzarite V, Hatch EI Jr (1999) Pre-term and particularly pre-labor cesarean section to avoid complications of gastroschisis. Pediatr Surg Int 15(2):97–104

    Article  CAS  PubMed  Google Scholar 

  38. Anteby EY, Sternhell K, Dicke JM (1999) The fetus with gastroschisis managed by a trial of labor: antepartum and intrapartum complications. J Perinatol 19(7):521–524

    Article  CAS  PubMed  Google Scholar 

  39. Lausman AY, Langer JC, Tai M, Seaward PG, Windrim RC, Kelly EN, Ryan G (2007) Gastroschisis: what is the average gestational age of spontaneous delivery? J Pediatr Surg 42(11):1816–1821. doi:10.1016/j.jpedsurg.2007.07.005

    Article  PubMed  Google Scholar 

  40. Huang J, Kurkchubasche AG, Carr SR, Wesselhoeft CW Jr, Tracy TF Jr, Luks FL (2002) Benefits of term delivery in infants with antenatally diagnosed gastroschisis. Obstet Gynecol 100(4):695–699

    Article  PubMed  Google Scholar 

  41. Carnaghan H, Pereira S, James CP, Charlesworth PB, Ghionzoli M, Mohamed E, Cross KM, Kiely E, Patel S, Desai A, Nicolaides K, Curry JI, Ade-Ajayi N, De Coppi P, Davenport M, David AL, Pierro A, Eaton S (2014) Is early delivery beneficial in gastroschisis? J Pediatr Surg 49(6):928–933. doi:10.1016/j.jpedsurg.2014.01.027

    Article  PubMed  Google Scholar 

  42. Wilson MS, Carroll MA, Braun SA, Walsh WF, Pietsch JB, Bennett KA (2012) Is preterm delivery indicated in fetuses with gastroschisis and antenatally detected bowel dilation? Fetal Diagn Ther 32(4):262–266. doi:10.1159/000338925

    Article  PubMed  Google Scholar 

  43. Auber F, Danzer E, Noche-Monnery ME, Sarnacki S, Trugnan G, Boudjemaa S, Audry G (2013) Enteric nervous system impairment in gastroschisis. Eur J Pediatric Surg 23(1):29–38. doi:10.1055/s-0032-1326955

  44. Santos MM, Tannuri U, Maksoud JG (2003) Alterations of enteric nerve plexus in experimental gastroschisis: is there a delay in the maturation? J Pediatr Surg 38(10):1506–1511

    Article  PubMed  Google Scholar 

  45. Vannucchi MG, Midrio P, Zardo C, Faussone-Pellegrini MS (2004) Neurofilament formation and synaptic activity are delayed in the myenteric neurons of the rat fetus with gastroschisis. Neurosci Lett 364(2):81–85. doi:10.1016/j.neulet.2004.03.095

    Article  CAS  PubMed  Google Scholar 

  46. Morrison JJ, Klein N, Chitty LS, Kocjan G, Walshe D, Goulding M, Geary MP, Pierro A, Rodeck CH (1998) Intra-amniotic inflammation in human gastroschisis: possible aetiology of postnatal bowel dysfunction. Br J Obstet Gynaecol 105(11):1200–1204

    Article  CAS  PubMed  Google Scholar 

  47. Api A, Olguner M, Hakguder G, Ates O, Ozer E, Akgur FM (2001) Intestinal damage in gastroschisis correlates with the concentration of intraamniotic meconium. J Pediatr Surg 36(12):1811–1815

    Article  CAS  PubMed  Google Scholar 

  48. Midrio P, Stefanutti G, Mussap M, D’Antona D, Zolpi E, Gamba P (2007) Amnioexchange for fetuses with gastroschisis: is it effective? J Pediatr Surg 42(5):777–782. doi:10.1016/j.jpedsurg.2006.12.029

    Article  PubMed  Google Scholar 

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Correspondence to Carmen Mesas Burgos.

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Mesas Burgos, C., Svenningsson, A., Vejde, J.H. et al. Outcomes in infants with prenatally diagnosed gastroschisis and planned preterm delivery. Pediatr Surg Int 31, 1047–1053 (2015). https://doi.org/10.1007/s00383-015-3795-8

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