Abstract
Case report
Focal cortical dysplasia (FCD) with calcification is rare. We presented a 13-year-old epileptic patient with FCD and calcification in the left frontal lobe. At age 24, the FCD lesion and the surrounding epileptogenic cortex and underlying subcortex were removed after chronic subdural electrode recording. Histological examination showed that the calcified lesion was not independent of the FCD lesion but located in the subcortical area of the FCD lesion. A neoplastic nature was ruled out for the lesion.
Discussion
The pathophysiological mechanism involved in the coexistence of FCD and calcification is discussed.
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References
Bronen RA, Vives KP, Kim JH, Fulbright RK, Spencer SS, Spencer DD (1997) Focal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors. Am J Neuroradiol 18:1141–1151
DiPaolo D, Zimmerman RA (1995) Solitary cortical tuber. Am J Neuroradiol 16:1360–1364
Honavar M, Meldrum B (1997) Epilepsy. In: Graham DI, Lantos PL (eds) Greenfield's neuropathology. 6th edn. Arnold, London, pp 936–938
Lombroso CT (2000) Can early postnatal closed head injury induce cortical dysplasia? Epilepsia 41:245–253
Maehara T, Shimizu H, Oda M, Arai N (1997) Coexistence of ganglioglioma and cortical dysplasia in a patient with intractable epilepsy—case report. Neurol Med Chir (Tokyo) 37:752–756
Maehara T, Arai N, Shimizu H, Yagishita A, Oda M (2000) Cortical dysplasia with occification. Epilepsia 41:1489–1493
Menor F, Marti-Bonmati L, Mulas F, Poyatos C, Cortina H (1992) Neuroimaging in tuberous sclerosis: a clinicoradiological evaluation in pediatric patients. Pediatr Radiol 183:227–238
Mizoguchi M, Iwaki T, Morioka T, Fukui M, Tateishi J (1998) Abnormal cytoarchitecture of cortical dysplasia verified by immunohistochemistry. Clin Neuropathol 17:100–109
Morioka T, Nishio S, Ishibashi H, Muraishi M, Hisada K, Shigeto H, Yamamoto T, Fukui M (1999) Intrinsic epileptogenicity of focal cortical dysplasia as revealed by magnetoencephalography and electrocorticography. Epilepsy Res 33:177–187
Morioka T, Hashiguchi K, Nagata S, Miyagi Y, Yoshida F, Shono T, Mihara F, Koga H, Sasaki T (2007) Additional hippocampectomy in the surgical management of intractable temporal lobe epilepsy associated with glioneuronal tumor. Neurol Res 29:807–815
Nishio S, Morioka T, Hamada Y, Hisada K, Fukui M (1999) Immunohistochemical expression of Trk receptor proteins in focal cortical dysplasia with intractable epilepsy. Neuropathol Appl Neurobiol 25:188–195
Nishio S, Morioka T, Takeshita I, Fukui M (2001) Nerve cell tumours of the cerebrum: variable clinical and pathological manifestations. J Clin Neurosci 8:225–230
Palmini A, Andermann E, Andermann F (1994) Prenatal events and genetic factors in epileptic patients with neuronal migration disorders. Epilepsia 35:965–973
Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, Jackson G, Lüders HO, Prayson R, Spreafico R, Vinters HV (2004) Terminology and classification of the cortical dysplasias. Neurology 62(Suppl 3):S2–8
Prayson RA, Estes MI, Morris HM (1993) Coexistence of neoplasia and cortical dysplasia in patients presenting with seizures. Epilepsia 34:609–615
Roper SN (1998) In utero irradiation of rats as a model of human cerebrocortical dysgenesis: a review. Epilepsy Res 32:63–74
Sarnat HB (1987) Disturbances of late neuronal migrations in the perinatal period. Am J Dis Child 141:969–980
Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369–387
Yagishita A, Arai N, Maehara T, Shimizu N, Tokumaru AM, Oda M (1997) Focal cortical dysplasia: appearance on MR images. Radiology 203:553–559
Yagishita A, Arai N (1999) Cortical tubers without other stigma of tuberous sclerosis: imaging and pathological findings. Neuroradiology 41:428–432
You SJ, Lee JK, Ko TS (2007) Epilepsy surgery in a patient with Lennox-Gastaut syndrome and cortical dysplasia. Brain Dev 29:167–70
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Samura, K., Morioka, T., Yoshida, F. et al. Focal cortical dysplasia with calcification: a case report. Childs Nerv Syst 24, 619–622 (2008). https://doi.org/10.1007/s00381-007-0566-4
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DOI: https://doi.org/10.1007/s00381-007-0566-4