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Focal cortical dysplasia with calcification: a case report

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Abstract

Case report

Focal cortical dysplasia (FCD) with calcification is rare. We presented a 13-year-old epileptic patient with FCD and calcification in the left frontal lobe. At age 24, the FCD lesion and the surrounding epileptogenic cortex and underlying subcortex were removed after chronic subdural electrode recording. Histological examination showed that the calcified lesion was not independent of the FCD lesion but located in the subcortical area of the FCD lesion. A neoplastic nature was ruled out for the lesion.

Discussion

The pathophysiological mechanism involved in the coexistence of FCD and calcification is discussed.

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References

  1. Bronen RA, Vives KP, Kim JH, Fulbright RK, Spencer SS, Spencer DD (1997) Focal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors. Am J Neuroradiol 18:1141–1151

    PubMed  CAS  Google Scholar 

  2. DiPaolo D, Zimmerman RA (1995) Solitary cortical tuber. Am J Neuroradiol 16:1360–1364

    PubMed  CAS  Google Scholar 

  3. Honavar M, Meldrum B (1997) Epilepsy. In: Graham DI, Lantos PL (eds) Greenfield's neuropathology. 6th edn. Arnold, London, pp 936–938

    Google Scholar 

  4. Lombroso CT (2000) Can early postnatal closed head injury induce cortical dysplasia? Epilepsia 41:245–253

    Article  PubMed  CAS  Google Scholar 

  5. Maehara T, Shimizu H, Oda M, Arai N (1997) Coexistence of ganglioglioma and cortical dysplasia in a patient with intractable epilepsy—case report. Neurol Med Chir (Tokyo) 37:752–756

    Article  CAS  Google Scholar 

  6. Maehara T, Arai N, Shimizu H, Yagishita A, Oda M (2000) Cortical dysplasia with occification. Epilepsia 41:1489–1493

    Article  PubMed  CAS  Google Scholar 

  7. Menor F, Marti-Bonmati L, Mulas F, Poyatos C, Cortina H (1992) Neuroimaging in tuberous sclerosis: a clinicoradiological evaluation in pediatric patients. Pediatr Radiol 183:227–238

    Google Scholar 

  8. Mizoguchi M, Iwaki T, Morioka T, Fukui M, Tateishi J (1998) Abnormal cytoarchitecture of cortical dysplasia verified by immunohistochemistry. Clin Neuropathol 17:100–109

    PubMed  CAS  Google Scholar 

  9. Morioka T, Nishio S, Ishibashi H, Muraishi M, Hisada K, Shigeto H, Yamamoto T, Fukui M (1999) Intrinsic epileptogenicity of focal cortical dysplasia as revealed by magnetoencephalography and electrocorticography. Epilepsy Res 33:177–187

    Article  PubMed  CAS  Google Scholar 

  10. Morioka T, Hashiguchi K, Nagata S, Miyagi Y, Yoshida F, Shono T, Mihara F, Koga H, Sasaki T (2007) Additional hippocampectomy in the surgical management of intractable temporal lobe epilepsy associated with glioneuronal tumor. Neurol Res 29:807–815

    Google Scholar 

  11. Nishio S, Morioka T, Hamada Y, Hisada K, Fukui M (1999) Immunohistochemical expression of Trk receptor proteins in focal cortical dysplasia with intractable epilepsy. Neuropathol Appl Neurobiol 25:188–195

    Article  PubMed  CAS  Google Scholar 

  12. Nishio S, Morioka T, Takeshita I, Fukui M (2001) Nerve cell tumours of the cerebrum: variable clinical and pathological manifestations. J Clin Neurosci 8:225–230

    Article  PubMed  CAS  Google Scholar 

  13. Palmini A, Andermann E, Andermann F (1994) Prenatal events and genetic factors in epileptic patients with neuronal migration disorders. Epilepsia 35:965–973

    Article  PubMed  CAS  Google Scholar 

  14. Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, Jackson G, Lüders HO, Prayson R, Spreafico R, Vinters HV (2004) Terminology and classification of the cortical dysplasias. Neurology 62(Suppl 3):S2–8

    PubMed  CAS  Google Scholar 

  15. Prayson RA, Estes MI, Morris HM (1993) Coexistence of neoplasia and cortical dysplasia in patients presenting with seizures. Epilepsia 34:609–615

    Article  PubMed  CAS  Google Scholar 

  16. Roper SN (1998) In utero irradiation of rats as a model of human cerebrocortical dysgenesis: a review. Epilepsy Res 32:63–74

    Article  PubMed  CAS  Google Scholar 

  17. Sarnat HB (1987) Disturbances of late neuronal migrations in the perinatal period. Am J Dis Child 141:969–980

    PubMed  CAS  Google Scholar 

  18. Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369–387

    PubMed  CAS  Google Scholar 

  19. Yagishita A, Arai N, Maehara T, Shimizu N, Tokumaru AM, Oda M (1997) Focal cortical dysplasia: appearance on MR images. Radiology 203:553–559

    PubMed  CAS  Google Scholar 

  20. Yagishita A, Arai N (1999) Cortical tubers without other stigma of tuberous sclerosis: imaging and pathological findings. Neuroradiology 41:428–432

    Article  PubMed  CAS  Google Scholar 

  21. You SJ, Lee JK, Ko TS (2007) Epilepsy surgery in a patient with Lennox-Gastaut syndrome and cortical dysplasia. Brain Dev 29:167–70

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Takato Morioka.

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Samura, K., Morioka, T., Yoshida, F. et al. Focal cortical dysplasia with calcification: a case report. Childs Nerv Syst 24, 619–622 (2008). https://doi.org/10.1007/s00381-007-0566-4

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  • DOI: https://doi.org/10.1007/s00381-007-0566-4

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